Mechanical Aspects of Pediatric Cardio Pulmonary Bypass

Hemolysis generation from a novel, linear positive displacement blood pump for cardiopulmonary bypass on a six kilogram piglet: a preliminary report

“…Some of these insults include hemodilution, hypothermia, exposure to foreign materials, non-pulsatile flow and non-physiologic shear stresses. 8 Significant strides have been made to ameliorate the sequelae of CPB via circuit surface modification, 9 pharmacologic intervention 10 and various new techniques. It is now understood that, in infants undergoing low to moderate complexity cardiac surgery, the contribution of inflammatory mediator production to post-operative morbidity is relatively limited.…”

John Kirklin's Impact on the Origins of Open Heart Surgery and the Congenital Heart Surgeons' Society

“…4 In 1934, Michael DeBakey and Schmidt patented a roller pump which was later modified for use in the heart-lung machine. 5 The first series of oxygenators were film-type oxygenators, in which a thin layer of blood was exposed to gas for gas exchange. The circuits were generally large, cumbersome to operate, and required large priming volumes.…”

“…4 In 1934, Michael DeBakey and Schmidt patented a roller pump which was later modified for use in the heart–lung machine. 5…”