Mechanical, antibacterial, biocompatible and microleakage evaluation of glass ionomer cement modified by nanohydroxyapatite/polyhexamethylene biguanide

Zhu, Keshi; Lu, Zhonghua; Xing, Jiawei; Chen, Sisi; Chen, Ruimin; Liu, Ren

doi:10.4012/dmj.2021-096

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…In this study, modified samples performed well improvements, and the cytotoxicity of modified GIC did not differ statistically from pure GIC. 23 In our study cell proliferation was observed as well, but no cytotoxic effect was observed.…”

Section: Figuresupporting

confidence: 48%

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

ÜNAL,

GÜÇYETMEZ TOPAL,

HAZMAN

2024

Turkiye Klinikleri J Dental Sci

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Glass ionomers, commonly used as base materials, are also employed as restorative materials after modifications are made to their content. By altering their physical properties through additives, attempts have been made to impart antibacterial characteristics. This study aimed to assess the cytotoxic effects resulting from the addition of calcium carbonate (marble powder) to conventional glass ionomer luting cement on gingival fibroblast cells. Material and Methods: Conventional glass ionomer cement (Ionofil U, VOCO, Germany) was used in this study. The specimens were divided into three groups: Group A-Glass ionomer without marble particles (control). Group B-Glass ionomer with 5% wt. Calcium Carbonate (marble particles) added to the powder component. Group C-Glass ionomer with 10% wt. Calcium carbonate (marble particles) added to the powder component. Prepared samples were kept in medium for 24 hours. The cytotoxicity levels of the biomaterials used in the study were determined using the MTT (3-4.5-dimethyl-thiazolyl-2.5-diphenyltetrazolium bromide) method on gingival fibroblast cell. Statistical evaluation was performed using one-way analysis of variance and post hoc Duncan test (p<0.05). Results: Biomaterials other than those in Group A, when applied to fibroblast cells, did not exhibit cytotoxicity; instead, they stimulated fibroblast cell proliferation. Group A reduced fibroblast cell viability rates at concentrations of 100%, 50%, and 25%. Conclusion: Marble powder enhanced glass ionomers showed potential for clinical applications as samples did not show cytotoxic effects. Further physical tests are needed to assess the clinical suitability of the materials.

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Section: Figuresupporting

confidence: 48%

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

ÜNAL,

GÜÇYETMEZ TOPAL,

HAZMAN

2024

Turkiye Klinikleri J Dental Sci

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“…The addition of commercially available nanohydroxyapatite (HAP) into a restorative material at different concentrations (0–10%) led to the identification of an optimum concentration of 6% HAP, at which the requirements of the ISO 9917-1 standard [ 9 ] regarding the setting time are fulfilled, and, at the same time, the physico-mechanical properties (compressive strength, microhardness, and microleakage) are improved [ 82 ]. A marginal increase in cell viability was also observed by Golkar et al [ 83 ] when using GIC containing 10% HAP.…”

Section: Resultsmentioning

confidence: 99%

Incorporation of Nanomaterials in Glass Ionomer Cements—Recent Developments and Future Perspectives: A Narrative Review

Fierăscu

2022

Nanomaterials

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Glass ionomer cements (GICs), restorative materials with commercial availability spanning over five decades, are widely applied due to their advantages (including bio-compatibility, fluoride release, or excellent bonding properties). However, GICs have shortcomings. Among the disadvantages limiting the application of GICs, the poor mechanical properties are the most significant. In order to enhance the mechanical or antimicrobial properties of these materials, the addition of nanomaterials represents a viable approach. The present paper aims to review the literature on the application of different types of nanomaterials for the enhancement of GICs’ mechanical and antimicrobial properties, which could lead to several clinical benefits, including better physical properties and the prevention of tooth decay. After applying the described methodology, representative articles published in the time period 2011-present were selected and included in the final review, covering the modification of GICs with metallic nanoparticles (Cu, Ag), metallic and metalloid oxide nanoparticles (TiO2, ZnO, MgO, Al2O3, ZrO2, SiO2), apatitic nanomaterials, and other nanomaterials or multi-component nanocomposites.

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“…In addition, the authors have shown the antibacterial activity of glass ionomer cement with the addition of 0.2%, 0.4%, 0.6%, and 0.8% PHMB vs. S. Mutans [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

et al. 2023

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Background:chronic apical periodontitis is a common pathology in dentistry, especially in endodontics. It is necessary to systematize data concerning commonly used irrigation solutions. The development of new protocols for endodontic treatment is a very promising direction. The use of a polyhexanide-based antiseptic can positively affect the results of endodontic treatment. Methods: the review was carried out involving the search for English language research and meta-analyses in the Google Scholar and PubMed databases. Results: the number of literary sources that were identified during the literature review is 180. After excluding publications that did not match the search criteria, the total number of articles included in the systematic review was determined to be 68. Conclusions: polyhexanide is a promising solution for infected root canal irrigation. The antibacterial activity of this substance is suitable for the elimination of pathogens responsible for the appearance of apical periodontitis.

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Mechanical, antibacterial, biocompatible and microleakage evaluation of glass ionomer cement modified by nanohydroxyapatite/polyhexamethylene biguanide

Cited by 9 publications

References 48 publications

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

Incorporation of Nanomaterials in Glass Ionomer Cements—Recent Developments and Future Perspectives: A Narrative Review

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

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