Glasses with the chemical composition of 52B2O3 – 12SiO2- 26Bi2O3 – (10 - x)TiO2 - xY2O3, (0 ≤ x ≥ 10)prepared using the melt-quench method. The goal of this study is to investigate the structural, mechanical, and radiation shielding characteristics of these samples. XRD analysis has explored the nature of the glass system. Molar volume obtained reduced while the density denotes increased in the present system. As the molar volume decrease inter-ionic distance, polaron radius, inter-nuclear distance, and Y-Y separation of the investigated glasses decreased. The mechanical characteristics depend on the glass structure of the current glasses sample. Ultrasonic velocities and elastic moduli (experimental and theoretical) for these glasses obtained observed to get enhanced. The radiation shielding efficiency investigated by Phy-X/PSD software. The mass attenuation coefficient (μ/ρ) mean free path (MFP), half-value layer (HVL), tenth value layer (TVL), and effective atomic number (Zeff), of glasses, have designed to simulate for gamma photon energies between 0.015 and 15 MeV.