Mechanical and in vitro performance of 13–93 bioactive glass scaffolds prepared by a polymer foam replication technique

Fu, Qiang; Rahaman, Mohamed N.; Bal, B. Sonny; Brown, Roger F.; Day, Delbert E.

doi:10.1016/j.actbio.2008.04.019

Cited by 272 publications

(211 citation statements)

References 48 publications

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“…Cell culture results and scanning electron microscopy (SEM) observations presented in ref. [105] confirmed an excellent attachment and subsequent proliferation of MC3T3-E1 pre-osteoblastic cells, both on the surface and in the interior of the scaffolds ( Figure 4). Another interesting approach in the development of bone TE scaffolds is to engineer constructs with graded porosity.…”

Section: Bioactive Glass Based Glass-ceramic Scaffoldssupporting

confidence: 49%

“…In addition to providing excellent in vitro bioactivity [14,43,94,109,110,115], cell biology behavior [15,105,114,118,119] and favorable mechanical properties [99,102,105], bioactive glassceramic scaffolds have shown superior in vivo behavior (e.g., bone formation, mineralization, higher interfacial strength between implant and bone) compared to the glass in particulate form [113] or compared to other bioactive materials (HA, tricalcium phosphate) [52].…”

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

“…Recent developments related to bone TE try to bridge this gap and overcome this problem by architectures and components carefully designed from comprehensive levels, i.e., from the macro-, meso-, micrometer down to the nanometer scale [101], including both multifunctional bioactive glass composite structures (see §3.2) and advanced bioactive glass-ceramic scaffolds exhibiting oriented microstructures, controlled porosity and directional mechanical properties [99,[102][103][104][105], as discussed in the following paragraphs. Most studies have investigated mainly the mechanical properties, in vitro and cell biological behavior of glass-ceramic scaffolds [13][14][15]30,43,52,94,95,97,99,, as summarized in Table 1, and scaffolds with compressive strength [99,102] and elastic modulus values [99,105] in magnitudes far above that of cancellous bone and close to the lower limit of cortical bone have been realized. Fu et al [99] fabricated bioactive glass (13-93) scaffolds with oriented (i.e., columnar and lamellar) microstructures and found that at an equivalent porosity of 55-60%, the columnar scaffolds had a compressive strength of 25 ± 3 MPa, compressive modulus of 1.2 GPa, and pore width of 90-110 µm, compared to values of 10 ± 2 MPa, 0.4 GPa, and 20-30 μm, respectively, for the lamellar scaffolds.…”

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

“…The limited strength and low fracture toughness (i.e., ability to resist fracture when a crack is present) of bioactive glasses has so far prevented their use for load-bearing implants [8,70,96,98], and thus the repair and regeneration of large bone defects at load-bearing anatomical sites (e.g., limbs) remains a clinical/orthopedic challenge [99,100]. Recent developments related to bone TE try to bridge this gap and overcome this problem by architectures and components carefully designed from comprehensive levels, i.e., from the macro-, meso-, micrometer down to the nanometer scale [101], including both multifunctional bioactive glass composite structures (see §3.2) and advanced bioactive glass-ceramic scaffolds exhibiting oriented microstructures, controlled porosity and directional mechanical properties [99,[102][103][104][105], as discussed in the following paragraphs. Most studies have investigated mainly the mechanical properties, in vitro and cell biological behavior of glass-ceramic scaffolds [13][14][15]30,43,52,94,95,97,99,, as summarized in Table 1, and scaffolds with compressive strength [99,102] and elastic modulus values [99,105] in magnitudes far above that of cancellous bone and close to the lower limit of cortical bone have been realized.…”

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

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Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

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Section: Bioactive Glass Based Glass-ceramic Scaffoldssupporting

confidence: 49%

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

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Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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“…BG with 13-93 composition (wt%) (53SiO 2 -6Na2O-12K 2 O-5MgO-20CaO-4P 2 O 5 ) was fabricated into cylinders using a polymer foam replication technique [15], with porosity of 85% ± 2%, dimensions of 4-mm diameter and 4-mm depth, and pore sizes ranging from 100 to 500 lm to match the microstructure of human trabecular bone [15]. The elemental content was confirmed using energydispersive xray spectrometry (EDAX) at the Hospital for Special Surgery (New York, NY) (Fig.…”

Section: Methodsmentioning

confidence: 99%

Bioactive Glass 13-93 as a Subchondral Substrate for Tissue-engineered Osteochondral Constructs: A Pilot Study

Jayabalan

Tan

Rahaman

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Replacement of diseased areas of the joint with tissue-engineered osteochondral grafts has shown potential in the treatment of osteoarthritis. Bioactive glasses are candidates for the osseous analog of these grafts. Questions/purposes (1) Does Bioactive Glass 13-93 (BG 13-93) as a subchondral substrate improve collagen and glycosaminoglycan production in a tissue-engineered cartilage layer? (2) Does BG 13-93 as a culture medium supplement increase the collagen and glycosaminoglycan production and improve the mechanical properties in a tissue-engineered cartilage layer?Methods In Study 1, bioactive glass samples (n = 4) were attached to a chondrocyte-seeded agarose layer to form an osteochondral construct, cultured for 6 weeks, and compared to controls. In Study 2, bioactive glass samples (n = 5) were cocultured with cell-seeded agarose for 6 weeks. The cell-seeded agarose layer was exposed to BG 13-93 either continuously or for the first or last 2 weeks in culture or had no exposure. Results Osteochondral constructs with a BG 13-93 base had improved glycosaminoglycan deposition but less collagen II content. Agarose scaffolds that had a temporal exposure to BG 13-93 within the culture medium had improved mechanical and biochemical properties compared to continuous or no exposure. Conclusions When used as a subchondral substrate, BG 13-93 did not improve biochemical properties compared to controls. However, as a culture medium supplement, BG 13-93 improved the biochemical and mechanical properties of a tissue-engineered cartilage layer. Clinical Relevance BG 13-93 may not be suitable in osteochondral constructs but could have potential as a medium supplement for neocartilage formation.

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Bioactive Glasses

Jaimes¹,

Poologasundarampillai²,

Brauer³

2019

Kirk-Othmer Encyclopedia of Chemical Technology

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Bioactive silicate glasses release ions when in contact with physiological solutions, leading to the formation of a biomimetic apatite surface layer. This apatite layer allows for protein adhesion, cell attachment and proliferation, and, subsequently, formation of a strong interfacial bond between bioactive glass and bone. In addition, bioactive glasses degrade in vivo and are replaced by new bone, and they thus help to regenerate bone tissue. These reactions are possible owing to the highly disrupted silicate structure of bioactive glasses, containing large concentrations of modifier ions and nonbridging oxygen atoms. Bioactive glasses have been used clinically since the mid‐1980s, and they are used mainly to treat bone defects. However, their mineralizing properties have also resulted in them being used in oral care products for the treatment of sensitive teeth and the remineralization of enamel.

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Mechanical and in vitro performance of 13–93 bioactive glass scaffolds prepared by a polymer foam replication technique

Cited by 272 publications

References 48 publications

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Bioactive Glass 13-93 as a Subchondral Substrate for Tissue-engineered Osteochondral Constructs: A Pilot Study

Bioactive Glasses

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