Mechanical and Histological Investigations on Pressureless Sintered SiC Dental Implants

Hashiguchi, Kunio; Hashimoto, Kenji

doi:10.2535/ofaj1936.75.6_281

Cited by 12 publications

(7 citation statements)

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“…A 1998 study showed that SiC coated titanium alloy pins are biocompatible (Santavirta et al, 1998). In a separate study, it was shown that the interface between a SiC implant and rat femoral bone was morphologically similar to that of a bone–hydroxyapatite interface (Hashiguchi & Hashimoto, 1999). Trials to incorporate SiC into a tissue engineering scaffold included the synthesis of a porous composite made of hydroxyapatite, alumina, and SiC.…”

Section: Introductionmentioning

confidence: 98%

Synthesis and characterization of porous bioactiveSiCtissue engineering scaffold

El‐Ghannam

Greenier

Johnson

et al. 2020

J Biomedical Materials Res

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Silicon carbide (SiC) is an inert material with excellent biocompatibility properties. A major issue that limits its use as a medical device is the difficult processing technique that requires hot pressing at a temperature (>2,000oC) and pressure (1,000–2,000 atm). In the present study, we developed a protocol to synthesize a porous SiC scaffold by pressing the powder at 50 MPa and heating at 900oC/2 hr. The surface of SiC was chemically modified by NaOH to facilitate sintering and induce bioactivity. Porous discs with 51.51 ± 3.17% porosity and interconnected pores in the size range from 1 to 1,000 μm were prepared using 40% PEG. The average compressive strength and Young's modulus of the scaffolds were 1.94 ± 0.70 and 169.2 ± 0.08 MPa, respectively. FTIR analysis confirmed the formation of biomimetic hydroxyapatite layer after 2 hr of immersion in simulated body fluid. The Ca/P ratio was dependent on the concentration of the silanol groups created on the material surface. Increasing the atomic % of silicon on the SiC surface from 33.27 ± 9.53% to 45.13 ± 4.74% resulted in a 76% increase in the osteocalcin expression by MC3T3‐E1 cells seeded on the material after 7 days. The cells colonized the entire thickness of the template and filled the pores with mineralized extracellular matrix after 14 days. Taken all together, the porous SiC scaffolds can serve as a bone graft for tissue reconstruction and cell delivery in trauma surgery.

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Section: Introductionmentioning

confidence: 98%

Synthesis and characterization of porous bioactiveSiCtissue engineering scaffold

El‐Ghannam

Greenier

Johnson

et al. 2020

J Biomedical Materials Res

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“…Out of the many material coatings that could be used, amorphous SiC seems to be the most promising because of this material's excellent mechanical and corrosion resistant properties as compared to standard silicon-based oxide or nitride coatings. 20 There are several methods for SiC film depositions including sputtering, 21 plasma spray, 22 chemical vapor deposition (CVD), 23 and plasma-enhanced chemical vapor deposition (PECVD) 12 Using CVD or PECVD deposition, the mechanical and optical properties of the deposited SiC film can be easily adjusted by altering the ratio of the gas precursors used. 16,17 One study showed that SiC appears to be cytocompatible on both basal and specific cyctocompatability levels.…”

Section: Introductionmentioning

confidence: 99%

“…Between 1 and 3 weeks, Higashiguchi reported callusing followed by fibrous tissue regenerating between the SiC and encapsulating bone surface with a similar morphology to traditional bone-ceramic interfaces. 20 There are several methods for SiC film depositions including sputtering, 21 plasma spray, 22 chemical vapor deposition (CVD), 23 and plasma-enhanced chemical vapor deposition (PECVD) 12 Using CVD or PECVD deposition, the mechanical and optical properties of the deposited SiC film can be easily adjusted by altering the ratio of the gas precursors used. Typically, the SiC films deposited with PECVD are amorphous hydrogenated SiC.…”

Section: Introductionmentioning

confidence: 99%

Demonstration of SiO₂/SiC‐based protective coating for dental ceramic prostheses

et al. 2019

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SiO2/SiC coatings were deposited onto ceramics disks using plasma‐enhanced chemical vapor deposition. The effects of deposition pressure and gas‐flow ratio on the refractive index, extinction coefficient, and SiC composition were studied. For the highest studied SiH4 to CH4 gas‐flow ratio of 1.5, the refractive index increased by 17% from 2.53 (at the wavelength of 845 nm) to 2.96 (at the wavelength of 400 nm). For the lowest studied SiH4 to CH4 gas‐flow ratio of 0.5, the refractive index only increased by 4% from 2.11 (at the wavelength of 845 nm) to 2.20 (at the wavelength of 400 nm). At higher deposition pressures, the variation in refractive index of the SiC coatings was significantly lower showing a slight increase from 1.93 (at a wavelength of 845 nm) to 1.96 at a wavelength of 400 nm. Except for the case of a low SiH4 to CH4 gas‐flow ratio of 0.5, for light with wavelengths ≤650 nm, the extinction coefficient of the SiC coatings increased significantly. Light with a wavelength >650 nm had an extinction coefficient near 0 in all cases. After annealing the sample at 400°C for 4 hours, hydrogen‐related bonds broke and the stress of the film was reduced from −245 to −71 MPa. By utilizing different thicknesses of SiC, the full standard dental shade guide was matched with the ΔE of each coated disk being less than 3.3 compared to the shade guide.

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“…Silicon carbide (SiC) has been used as a biomaterial, either as a coating material for titanium pins or as a SiC implant in rat femoral bone. 7,8 Unfavorable outcomes for material characterization during in vitro evaluation as a scaffold for tissue engineering, however, were reported as a result of inadequate cell expansion. 9 This encouraged scientists to improve SiC surface qualities by either looking at improved production techniques or covering SiC with bioactive materials, such as silica.…”

mentioning

confidence: 99%

In Vivo Analysis of Porous Bioactive Silicon Carbide Scaffold for Craniofacial Bone Augmentation

Alfotawi,

Premnath,

El-Ghannam

et al. 2023

Journal of Craniofacial Surgery

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Background: Bone augmentation is a vital area of research because of its high clinical demand and the reported complications associated with the available biomaterials. Purpose: The study assess the role of decellurized skeletal muscle (DSM) when combined with synthesized porous bioactive silicon carbide (SiC) ceramic and evaluated its ability to augment bone calvaria in a rat model. Material and Methods: Eighteen rats were divided into 2 groups; group 1 (n=9), SiC discs (10 × 0.2 mm) pre-treated with 20% NaOH were placed as an onlay grafts on calvarial bone. Meanwhile, in group 2 (n=9), SiC discs pre-treated with 20% NaOH (10 × 0.2 mm) were covered with DSM. After 12 weeks, the grafted tissues were harvested and examined using cone-beam computed tomography, mechanical testing, and histologic analysis. Results: Cone-beam computed tomography for group 2 showed more radio-opacity for the remnant of SiC compared with native bone. The surface area and volume of radio-opacity were 2.48 mm2 ± 1.6 and 14.9 ± 7.8 mm3, respectively. The estimated quantitative average surface area of the radio-opacity for group 1 and volume were 2.55 mm2 ± (Sd=3.7) and 11.25 ± (Sd=8.9), respectively. Mechanically, comparable values of the flexural strength and statistically significant higher modulus of elasticity of calvaria in group 1 compared with group 2 and control (P<0.001). Histologically, group 2 region of woven bone was seen close to the lamellar bone (native bone), and there was immature bone present near the implanted SiC. Conclusion: The tested construct made of SiC/DSM has potential to osteointegrate into native bone, making it a suitable material for bone augmentation.

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Mechanical and Histological Investigations on Pressureless Sintered SiC Dental Implants

Abstract: Summary: The effect of sinterability manufacturing conditions, such as Si/C ratio, additives, firing temperature on mechanical properties of pressureless sintered SiC having electrical resistivity and oxidation behaviour in moist were studied.

Cited by 12 publications

References 12 publications

Synthesis and characterization of porous bioactiveSiCtissue engineering scaffold

Synthesis and characterization of porous bioactiveSiCtissue engineering scaffold

Demonstration of SiO₂/SiC‐based protective coating for dental ceramic prostheses

In Vivo Analysis of Porous Bioactive Silicon Carbide Scaffold for Craniofacial Bone Augmentation

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Mechanical and Histological Investigations on Pressureless Sintered SiC Dental Implants

Abstract: Summary: The effect of sinterability manufacturing conditions, such as Si/C ratio, additives, firing temperature on mechanical properties of pressureless sintered SiC having electrical resistivity and oxidation behaviour in moist were studied.

Cited by 12 publications

References 12 publications

Synthesis and characterization of porous bioactiveSiCtissue engineering scaffold

Synthesis and characterization of porous bioactiveSiCtissue engineering scaffold

Demonstration of SiO2/SiC‐based protective coating for dental ceramic prostheses

In Vivo Analysis of Porous Bioactive Silicon Carbide Scaffold for Craniofacial Bone Augmentation

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Demonstration of SiO₂/SiC‐based protective coating for dental ceramic prostheses