Mechanical and degradation property improvement in a biocompatible Mg-Ca-Sr alloy by thermomechanical processing

Henderson, Hunter B.; Ramaswamy, Vidhya; Wilson-Heid, Alexander E.; Kesler, Michael S.; Allen, Josephine B.; Manuel, Michele V.

doi:10.1016/j.jmbbm.2018.02.001

Cited by 30 publications

(20 citation statements)

References 31 publications

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“…In the study all three groups of rats recovered after surgery, and there were no incision infections, rejections, and other related complications, similar to the reports by Griebel [49] and Henderson, et al [50]. This showed that the Mg-1Zn-0.3Zr-2Gd-1Ca alloy implant had good compatibility with rat tissues.…”

Section: Author Contributionssupporting

confidence: 87%

Short-Term Application of Chitosan Coated Mg-1Zn-0.3Zr-2Gd-1Ca Alloy Bone Implants in Osteoporotic Fractures

Wang¹,

Li²,

Sun³

et al. 2020

Int J Metall Met Phys

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With the rapid aging of the global population, osteoporosis seriously affects human life and health, and the most serious clinical manifestation is osteoporosis fracture. Therefore, biomedical workers have been investing a lot of research on biomedical materials in the treatment of osteoporotic fracture. The aim of this research is to assess the biodegradability and biocompatibility of chitosan-coated Mg-1Zn-0.3Zr-2Gd-1Ca alloy as bone screws, and to explore the feasibility of the chitosan coated Mg-1Zn-0.3Zr-2Gd-1Ca alloy in the treatment of osteoporotic fractures. In this study, the uncoated Mg-1Zn-0.3Zr-2Gd-1Ca alloy screws and chitosan-coated Mg-1Zn-0.3Zr-2Gd-1Ca alloy screws were implanted into the fracture sites of rats, respectively. Then the X-ray changes of the operation areas were observe that different times. The degradation behavior of bone screws was evaluated for by scanning electron microscopy (SEM) and energy dispersion spectrum (EDS). The bio-safety of the Mg-1Zn-0.3Zr-2Gd-1Ca alloy to rat liver and kidney tissues were determined by eosin staining, and the Mg and Ca ions levels in peripheral blood were measured. The postoperative vital signs were stable and no surgical complications were observed. X-ray images showed that both bare group and chitosan group had good fixation after surgery. Inflammatory exudation could be seen in all groups. However, SEM results showed the implants in chitosan group had less corrosion rate than that of in bare group with a complete structure. The main elements of degradation products in bare group and chitosan were Mg, O, Ca, and Zn as shown by EDS analysis. Histopathological and serological tests showed that there was no significant toxicity of chitosan coated bone nails on SD rats. Chitosan coated Mg-1Zn-0.3Zr-2Gd-1Ca alloy could not only effectively retard the degradation rate of Mg-1Zn-0.3Zr-2Gd-1Ca alloys in rats but had good biocompatibility in rats, which was more favorable for fracture repair and suggested its possible clinical application.

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Section: Author Contributionssupporting

confidence: 87%

Short-Term Application of Chitosan Coated Mg-1Zn-0.3Zr-2Gd-1Ca Alloy Bone Implants in Osteoporotic Fractures

Wang¹,

Li²,

Sun³

et al. 2020

Int J Metall Met Phys

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“…It has been proved that plastic deformation not only has good grain refinement effect but also can make the dendritic second phases into small particles in Mg alloys [12][13][14][15], which is beneficial to the enhancement of mechanical properties and corrosion resistance. Plastic deformation, especially severe plastic deformation (SPD), is an effective way to improve mechanical property and corrosion resistance of Mg alloys [16,17].…”

Section: Introductionmentioning

confidence: 99%

Effects of ECAP Extrusion on the Microstructure, Mechanical Properties and Biodegradability of Mg–2Zn–xGd–0.5Zr Alloys

Chen

Zhu

Tan

et al. 2020

Acta Metall. Sin. (Engl. Lett.)

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Effects of equal channel angular pressing (ECAP) extrusion on the microstructure, mechanical properties and biodegradability of Mg-2Zn-xGd-0.5Zr (x = 0, 0.5, 1, 2 wt%) alloys were studied in this work. Microstructure analysis, tensile test at ambient temperature, immersion test and electrochemical test in Hank's solution were carried out. The results showed that Gd could further enhance the grain refinement during the ECAP extrusion. Both Gd addition and ECAP extrusion could improve the mechanical properties of the alloys, and the extrusion played the dominant role. Minor addition of Gd (0.5-1 wt%) could obviously enhance the corrosion resistance of the alloys. To some extent, ECAP extrusion improved the corrosion resistance of the alloys due to the change of second phases distribution and the refinement of grains. Further increase in extrusion pass was detrimental to the improvement of the corrosion resistance as a result of increment of the grain boundaries.

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“…1,2 It is mainly attributed to: (i) great strength-to-weight ratio, 2 (ii) good resistance to electromagnetic radiation, 3 (iii) availability, 4 (iv) good cast-ability, 5 (v) low density, (vi) good machinability, 1,6,7 (vii) high dimensional accuracy, 8,9 and (viii) good damping properties. 7 Moreover, Mg is the study hot spot in the biomedical application fields mainly attributed to: (i) the good biodegradable property which eliminates the need for secondary removal surgical of implants, 6,10 (ii) the excellent biocompatibility property which rises the rate of bone formation, 11,12 (iii) good mechanical compatibility, 8,13 (iv) low module and density that are close to the human bone GPa and 1.75-2.1 g/cm 3 , respectively) and result reduction of the stress shielding effect. 14,15 However, the low fracture strain and strength of Mg at room temperature due to the HCP structure as well as its high corrosion rate can restrict its extensive application.…”

Section: Introductionmentioning

confidence: 99%

“…8 Furthermore, they have beneficial properties for bone forming. 13,9 Ternary Mg-Sr-Ca alloys are a favorable candidate owing to contribution of both Sr and Ca alloying properties in Mg. Furthermore, these ternary alloys have antitumor and antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, these ternary alloys have antitumor and antimicrobial properties. 13 Bornapour et al 17 fabricated Mg-0.3Sr-0.3Ca via melting technique followed by homogenization at 400 C for 8 h. The Mg-0.3Sr-0.3Ca alloy showed tensile and compressive yield strengths (TYS and CYS) about 49 and 38 MPa, respectively. This alloy also showed tension and compressive failure strains (TFS and CFS) of 9.5 and 27, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Microstructure and mechanical characterizations of graphene nanoplatelets-reinforced Mg–Sr–Ca alloy as a novel composite in structural and biomedical applications

Ramezanzade

Ebrahimi

Parizi

et al. 2019

Journal of Composite Materials

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In this study, the novel composites were fabricated by the introduction of Mg-0.3Sr-0.3Ca alloy as the matrix and addition of different amounts of graphene nanoplatelets (0.1, 0.2, and 0.4 wt.%) as reinforcement using a stir casting technique followed by homogenization and extrusion in order to improve the mechanical properties of the base alloy. Optimum weight percent of adding graphene nanoplatelets was 0.2 wt.%. The addition of 0.2 wt.% graphene nanoplatelets in the extruded Mg–Sr–Ca alloy led to the grain refinement (∼36%), the decrease of anisotropy (∼14%) and the lowest twin formation. Moreover, the tensile and compressive yield strengths and tensile and compressive fracture strains of extruded Mg-0.3Sr-0.3Ca/0.2GNP composite were enhanced by 22.8%, 66.7%, 43.1% and 28%, respectively. The load transfer was significant strengthening mechanism. The uniform dispersion of graphene nanoplatelets followed by the increase of non-basal slip and grain refinement improved tensile fracture strain. In addition to maintained factors, the increase of compressive fracture strain in the extruded Mg-0.3Sr-0.3Ca/0.2GNP composite was affected by local stresses caused by twins which resulted non-basal slip and conserved basal slip due to presence of twins. Simultaneously, enhancement of the strengthening and elongation efficiencies in both tensile and compressive tests was achieved in Mg-0.3Ca-0.3Sr/0.2GNP. The biocorrosion behavior of extruded Mg-0.3Sr-0.3Ca/0.2GNP composite was promoted by 11% compared with Mg-0.3Sr-0.3Ca alloy. Comparative plots indicated that the fabricated materials can be introduced as a new class of composites for the purpose of structural as well as biomedical applications.

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Mechanical and degradation property improvement in a biocompatible Mg-Ca-Sr alloy by thermomechanical processing

Cited by 30 publications

References 31 publications

Short-Term Application of Chitosan Coated Mg-1Zn-0.3Zr-2Gd-1Ca Alloy Bone Implants in Osteoporotic Fractures

Short-Term Application of Chitosan Coated Mg-1Zn-0.3Zr-2Gd-1Ca Alloy Bone Implants in Osteoporotic Fractures

Effects of ECAP Extrusion on the Microstructure, Mechanical Properties and Biodegradability of Mg–2Zn–xGd–0.5Zr Alloys

Microstructure and mechanical characterizations of graphene nanoplatelets-reinforced Mg–Sr–Ca alloy as a novel composite in structural and biomedical applications

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