Mechanical and Chemical Regulation of Arterial and Venous Specification

Sato, Thomas N.

doi:10.1007/978-3-642-30856-7_1

Cited by 4 publications

(7 citation statements)

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“…6 B). Mechanical stimuli, such as shear-stress, could be such circulation-dependent signals ( Sato, 2013 ) ( Fig. 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…7 ). Humoral factors ( Sato, 2013 ) and immune cells and/or factors presented by them are also candidates.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to these canonical functions, the cardiovascular system also locally regulates organ development and function. Hemodynamic force plays important roles in arteriovenous specification ( Sato, 2013 ), vascular endothelial cell (vEC) behavior ( Gimbrone, 1999 ), vascular extracellular matrix (ECM) remodeling ( Califano and Reinhart-King, 2010 ; Kohn et al, 2015 ; Reinhart-King et al, 2008 ), vascular mural cell (vMC) recruitment ( Sato, 2013 ), tissue/organ regeneration ( Rabbany et al, 2013 ) and organ morphogenesis ( Serluca et al, 2002 ). While these locally acting noncanonical functions are also important, it is generally perceived that the canonical function (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Re-evaluating functional landscape of the cardiovascular system during development

et al. 2017

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The cardiovascular system facilitates body-wide distribution of oxygen, a vital process for the development and survival of virtually all vertebrates. However, the zebrafish, a vertebrate model organism, appears to form organs and survive mid-larval periods without a functional cardiovascular system. Despite such dispensability, it is the first organ to develop. Such enigma prompted us to hypothesize other cardiovascular functions that are important for developmental and/or physiological processes. Hence, systematic cellular ablations and functional perturbations were performed on the zebrafish cardiovascular system to gain comprehensive and body-wide understanding of such functions and to elucidate the underlying mechanisms. This approach identifies a set of organ-specific genes, each implicated for important functions. The study also unveils distinct cardiovascular mechanisms, each differentially regulating their expressions in organ-specific and oxygen-independent manners. Such mechanisms are mediated by organ-vessel interactions, circulation-dependent signals, and circulation-independent beating-heart-derived signals. A comprehensive and body-wide functional landscape of the cardiovascular system reported herein may provide clues as to why it is the first organ to develop. Furthermore, these data could serve as a resource for the study of organ development and function.

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“…6 B). Mechanical stimuli, such as shear-stress, could be such circulation-dependent signals ( Sato, 2013 ) ( Fig. 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…7 ). Humoral factors ( Sato, 2013 ) and immune cells and/or factors presented by them are also candidates.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Re-evaluating functional landscape of the cardiovascular system during development

et al. 2017

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“…Most of the computer models of sprouting angiogenesis developed so far have focused either on the role played by biological or mechanical signals on the process (Title, et al 2013 ; Sato 2013 ). Very few models (Vilanova et al 2014 ; Manoussaki 2003 ; Nivlouei et al 2021 ; Vega et al 2020 ) have been used to investigate the interaction between these two types of stimuli and their relative role on the process.…”

Section: Remaining Challenges In Computational Modeling Of Angiogenesismentioning

confidence: 99%

On the role of mechanical signals on sprouting angiogenesis through computer modeling approaches

Abdalrahman

Checa

2022

Biomech Model Mechanobiol

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Sprouting angiogenesis, the formation of new vessels from preexisting vasculature, is an essential process in the regeneration of new tissues as well as in the development of some diseases like cancer. Although early studies identified chemical signaling as the main driver of this process, many recent studies have shown a strong role of mechanical signals in the formation of new capillaries. Different types of mechanical signals (e.g., external forces, cell traction forces, and blood flow-induced shear forces) have been shown to play distinct roles in the process; however, their interplay remains still largely unknown. During the last decades, mathematical and computational modeling approaches have been developed to investigate and better understand the mechanisms behind mechanically driven angiogenesis. In this manuscript, we review computational models of angiogenesis with a focus on models investigating the role of mechanics on the process. Our aim is not to provide a detailed review on model methodology but to describe what we have learnt from these models. We classify models according to the mechanical signals being investigated and describe how models have looked into their role on the angiogenic process. We show that a better understanding of the mechanobiology of the angiogenic process will require the development of computer models that incorporate the interactions between the multiple mechanical signals and their effect on cellular responses, since they all seem to play a key in sprout patterning. In the end, we describe some of the remaining challenges of computational modeling of angiogenesis and discuss potential avenues for future research.

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“…In addition to these canonical functions, the cardiovascular system also locally regulates organ development and function. Hemodynamic force plays important roles in arteriovenous-specification (Sato, 2013), vascular endothelial cell (vEC) behavior (Gimbrone, 1999), vascular extracellular matrix (ECM) remodeling (Califano and Reinhart-King, 2010;Kohn et al, 2015;Reinhart-King et al, 2008), vascular mural cell (vMC) recruitment (Sato, 2013), tissue/organ regeneration (Rabbany et al, 2013) and organ morphogenesis (Serluca et al, 2002). While these locally-acting non-canonical functions are also important, it is generally perceived that the canonical function (i.e., the distantlyacting function) is more predominantly critical for organismal development, function and survival.…”

Section: Introductionmentioning

confidence: 99%

Re-evaluating functional landscape of the cardiovascular system during development

Takada

Omae

Sagawa

et al. 2017

Preprint

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The cardiovascular system facilitates body-wide distribution of oxygen, a vital process for development and survival of virtually all vertebrates. However, zebrafish, a vertebrate model organism, appears to form organs and survive mid-larval periods without the functional cardiovascular system. Despite such dispensability, it is the first organ to develop. Such enigma prompted us to hypothesize yet other cardiovascular functions that are important for developmental and/or physiological processes. Hence, systematic cellular ablations and functional perturbations are performed on zebrafish cardiovascular system to gain comprehensive and body-wide understanding of such functions and to elucidate underlying mechanisms. This approach identifies a set of organ-specific genes, each implicated for important functions. The study also unveils distinct cardiovascular mechanisms, each differentially regulating their expressions in organ-specific and oxygen-independent manners. Such mechanisms are mediated by organ-vessel interactions, circulation-dependent signals, and circulation-independent beating-heart-derived signals. Hence, a comprehensive and body-wide functional landscape of the cardiovascular system reported herein may provide a clue as to why it is the first organ to develop. Furthermore, the dataset herein could serve as a resource for the study of organ development and function.SUMMARY STATEMENTThe body-wide landscape of the cardiovascular functions during development is reported. Such landscape may provide a clue as to why the cardiovascular system is the first organ to develop.

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Mechanical and Chemical Regulation of Arterial and Venous Specification

Cited by 4 publications

References 58 publications

Re-evaluating functional landscape of the cardiovascular system during development

Re-evaluating functional landscape of the cardiovascular system during development

On the role of mechanical signals on sprouting angiogenesis through computer modeling approaches

Re-evaluating functional landscape of the cardiovascular system during development

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