Mechanical and biological properties of nanoporous carbon membranes

Abstract

Implantable blood glucose sensors have inadequate membrane-tissue interfaces for long term use. Biofouling and inflammation processes restrict biosensor membrane stability. An ideal biosensor membrane material must prevent protein adsorption and exhibit cell compatibility. In addition, a membrane must exhibit high porosity and low thickness in order to allow the biosensor to respond to analyte fluctuations. In this study, the structural, mechanical and biological properties of nanoporous alumina membranes coated with diamond-like carbon thin films were examined using scanning probe microscopy, nanoindentation and MTT viability assay. We anticipate that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function.

Pulsed Laser Deposition of Nanoporous Cobalt Thin Films

“…In a recent study, the authors have demonstrated nanoporous alumina membranes coated using pulsed laser deposition exhibited slightly larger pore sizes than the as-prepared membranes. 18 An increase in pore size resulted from localized heating of the nanoporous alumina membrane during the film deposition process. In the previous study, the coated nanoporous alumina membranes exhibited hardness and Young’s modulus values slightly lower than those of as-prepared nanoporous alumina membranes due to their slightly larger pore sizes.…”

Continuous glucose monitoring technologies: state of the art and future perspectives in view of artificial pancreas

“…К таким поверхностям относится нанопористый ди-оксид титана, нанопористый кремний и нанопори-стый углерод [60,61]. Предполагается, что высокие значения аспектного отношения, характерные для поверхностей на основе этих наноматериалов, по-зволяют воздействовать на процессы клеточной пролиферации и дифференцировки.…”

Emerging synergy between nanotechnology and implantable biosensors: A review

“…While the nature of the reported improvement from the use of nanostructured materials is still under debate, a number of implantable devices have started to employ such nanostructuring of their outer membrane surface to alleviate foreign body response (Ainslie et al 2008). Some of the nanostructured surfaces include nanoporous titania (Popat et al 2007; Sahlin et al 2006), nanoporous silicon (Ainslie et al 2008; Desai et al 2000; Lopez et al 2006; Striemer et al 2007), nanoporous carbon (Narayan et al 2008) etc . These nanostructured materials possessing high aspect ratio features, can alter cell phenotype, proliferation, and differentiation (Lopez et al 2006; Saha et al 2007).…”