Mechanical activation of VE-cadherin stimulates AMPK to increase endothelial cell metabolism and vasodilation
Nicholas M. Cronin,
Logan W. Dawson,
Kris A. DeMali
Abstract:Endothelia cells respond to mechanical force by stimulating cellular signaling, but how these pathways are linked to elevations in cell metabolism and whether metabolism supports the mechanical response remains poorly understood. Here, we show that application of force to VE cadherin stimulates liver kinase B1 (LKB1) to activate AMP-activated protein kinase (AMPK), a master regulator of energy homeostasis. VE-cadherin stimulated AMPK increases eNOS activity and localization to the plasma membrane as well as re… Show more
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