Mebendazole Mesylate Monohydrate: A New Route to Improve the Solubility of Mebendazole Polymorphs

Novel pharmaceutical salts of albendazole

“…Salts of mebendazole with carboxylic acids and sulfonic acids have been reported. [18][19][20] Similarly, a flubendazole salt with maleic acid was published recently. 21 Even though there are related drugs listed in Scheme 1a from literature reports, the crystal structures of albendazole salts are new observations in present study.…”

“…20 Bendazole salts with HCl, HBr, sulfonic acids such as methane, benzene, toluene, and naphthalene, and aliphatic carboxylic acids such as formic, maleic and oxalic have been reported. [40][41][42][43][44] (Table 7) We present new salts of L-tartaric acid and hydroxy benzoic acids with ABZ in addition to those from previous studies.…”

Rational design, supramolecular synthesis and solid state characterization of two bicomponent solid forms of mebendazole

“…20 In contrast, there is not much literature about multicomponent drug crystals incorporating perchloric acid and. 21 among the cocrystals and salts reported in the literature [23][24][25][26][27][28] , including one nitrate salt previously reported by us 29 .…”

Vibrational spectroscopy used in polymorphic analysis

“…Mebendazole mesylate monohydrate (MEB), a new stable salt of mebendazole, has been synthesized and fully characterized [42]. It was obtained from recrystallization of MEB forms A, B, or C in diverse solvents with the addition of methyl sulfonic acid solution.…”