Meat intake and bladder cancer risk in a Swedish prospective cohort

Larsson, Susanna C.; Johansson, Jan‐Erik; Andersson, Swen‐Olof; Wolk, Alicja

doi:10.1007/s10552-008-9214-x

Cited by 20 publications

(25 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nitrosamines have been shown to cause a wide range of tumors, including cancer of the bladder, in more than 40 animal species (3). Intake of red meat (the most important source of heme iron) has shown inconsistent results with bladder cancer in epidemiologic studies (4,5). A recent study has shown a positive association between dietary nitrite from processed meat and bladder cancer risk (6).…”

Section: Introductionmentioning

confidence: 99%

Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Jakszyn

González

Luján-Barroso

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC).Methods: Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, gender, and study center and adjusted for total energy intake, smoking status, lifetime intensity of smoking, duration of smoking, educational level, and BMI.Results: After a mean follow-up of 8.7 years, 1,001 participants were diagnosed with bladder cancer. We found no overall association between intake of red meat (log 2 HR: 1.06; 95% CI: 0.99-1.13), nitrosamines (log 2 HR: 1.09; 95% CI: 0.92-1.30 and HR: 0.98; 95% CI: 0.92-1.05 for ENOC and NDMA, respectively) or heme iron (log 2 HR: 1.05; 95 CI: 0.99-1.12) and bladder cancer risk. The associations did not vary by sex, high-versus lowrisk bladder cancers, smoking status, or occupation (high vs. low risk).Conclusions: Our findings do not support an effect of red meat intake, nitrosamines (endogenous or exogenous), or heme iron intake on bladder cancer risk. Cancer Epidemiol Biomarkers Prev; 20(3); 555-9. Ó2011 AACR.

show abstract

Section: Introductionmentioning

confidence: 99%

Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Jakszyn

González

Luján-Barroso

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…and wide range of meat and processed meat consumption that may lead to measurement errors [24]. For example, in a study higher meat intake was evident in higher intake of energy and alcohol [19]. The same was also noted with high red meat intake and older men who were ever smokers, heavy smokers and high energy takers [7;13].…”

Section: Resultsmentioning

confidence: 99%

“…A recent study by Larsson et al showed no association while an earlier case-control study showed that the consumption of fried meat, pork and sausages were associated with increased risk of developing BCa (OR=1.4, 95% CI=1.0-1.8) [19]. One study from Canada showed significantly increased risk between BCa and high intake of total meat (OR=1.6, 95% CI=1.…”

Section: Bca and Meatmentioning

confidence: 93%

“…One study from Canada showed significantly increased risk between BCa and high intake of total meat (OR=1.6, 95% CI=1. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], red meat and processed meat (OR=1.3, 95% CI= 1.0-1.7) [7]. In the study of the cohorts of HPFS and NHS, total and red meat as well as hot dogs or processed meat were not significantly related to the risk [14].…”

Section: Bca and Meatmentioning

confidence: 99%

See 1 more Smart Citation

Review of Meat and Caffeine and the Risk of Bladder Cancer

Nasr¹

2015

IJNFS

View full text Add to dashboard Cite

Abstract:Bladder cancer (BCa) is a main health issue in both developed and developing countries, especially for men with an incidence that is three to five times greater than that of women. The majority of bladder cancer occurs in males and there is a 14-fold variation in the incidence internationally. About 1,596,670 new cancer cases were diagnosed in 2011. This estimate did not include carcinoma in situ (noninvasive cancer) of any site except urinary bladder. It is commonly known that nutrition has a role in preventing cancer in general. Additionally, new dispute has risen over the effect of dietary factors such as meat and coffee in bladder cancer, which has yielded contradicting results. The review relied on previous researches and studies related to our assumption that meat and caffeine intake is not proved to be directly related to BCa. The study showed that there is no credible evidence stating that BCa is the result of meat and caffeine intake. This was due to the contradiction found in the studies referred to or consulted in the study. The lack of statistical association of meat types, the different methods of cooking, samples under study, and lifestyle enrollment are all considered important variables that were neglected in previous researches. These limitations supported the lack of credibility of such studies that correlated BCa to meat and caffeine intake.

show abstract

“…Whereas the EPIC prospective study reported null results (Jakszyn et al, 2011), the study by Michaud et al showed an increased risk of bladder cancer associated with bacon intake (Michaud et al, 2006). A third prospective study on meat intake and risk of bladder cancer displayed again null results on the effect of meat consumption (Larsson et al, 2009).…”

Section: Discussionmentioning

confidence: 96%

Meat Consumption, Animal Products, and the Risk of Bladder Cancer: A Case-Control Study in Uruguayan Men

Ronco

Mendilaharsu²,

Boffetta³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

In the time period 1996-2004, all incident cases of bladder cancer were included in a case-control study in order to study the role of meat consumption and product animals in the etiology of urothelial cancer. The study included 225 cases and 1,510 hospitalized controls with non-neoplastic conditions, not related to smoking and alcohol drinking. Relative risks, approximated by the odds ratios, were calculated in order to clarify the effect of meat consumption in the etiology of urothelial cancer. Total meat consumption (OR 1.47, 95% CI 1.02-2.11), total processed meat (OR 1.57, 95% CI 1.08-2.27), frankfurters (hot dogs) (OR 2.03, 95% CI 1.28-3.21), ham (OR 1.79, 95% CI 1.21-2.67) and salted meat (OR 2.73, 95% CI 1.78-4.18) were positively associated with risk of bladder cancer. Animal products, like cheese, whole milk, and total eggs were also associated with bladder cancer risk (OR for eggs 4.05, 95% CI 2.68-6.12). In conclusion, total meat, processed meat, and eggs could play an important role in the etiology of bladder cancer in Uruguay.

show abstract

Meat intake and bladder cancer risk in a Swedish prospective cohort

Abstract: These results do not support the hypothesis that intake of red meat, processed meat, poultry, or fried meats/fish is associated with the risk of developing bladder cancer.

Cited by 20 publications

References 24 publications

Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Review of Meat and Caffeine and the Risk of Bladder Cancer

Meat Consumption, Animal Products, and the Risk of Bladder Cancer: A Case-Control Study in Uruguayan Men

Contact Info

Product

Resources

About