Measuring wall shear stress distribution in the carotid artery in an African population: Computational fluid dynamics versus ultrasound doppler velocimetry

Onwuzu, Sobechukwu; Ugwu, AC; Mbah, Gce; Onwuzu, Ifunanya S

doi:10.1016/j.radi.2020.11.018

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…Although the AAWT diameter showed no significant differences between male and female healthy volunteers, male healthy volunteers had thicker AAWT diameters than their female counterparts. Similarly, carotid artery intima-media thickness has been reported to be thicker in healthy males than in healthy females as well [5]. The thicker AAWT in healthy males agrees with earlier findings that reported the abdominal aorta luminal diameter and wall thickness diameter to dilate for about 25-30% in healthy subjects especially in males [18] to compensate for wall stress built up in the abdominal aorta over time [19].…”

Section: Discussionsupporting

confidence: 85%

“…Similarly, plaques may begin to develop in the aortic intima-media complex, especially in adulthood and old age [4]. These changes in the wall of the abdominal aorta compromise the normal luminal dimension of the abdominal aorta and predispose individuals to some cardiovascular diseases [5]. Atherosclerosis of the abdominal aorta is often associated with the development of cardiovascular disease risk factors such as hypertension, hyperlipidaemia, and Diabetes [6].…”

Section: Introductionmentioning

confidence: 99%

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Reference values of abdominal aorta wall thickness and Doppler indices in a Nigerian population

Okpaleke,

Ugwuanyi,

Ogolodom

et al. 2023

ajhs

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Introduction : There is a paucity of data on the association between Doppler indices, the wall thickness of the abdominal aorta and the development of atherosclerosis in Nigeria. This study aimed to establish reference data of the abdominal aorta wall thickness and their selected Doppler indices in Abuja, Nigeria. Methodology : This cross-sectional prospective study enlisted volunteer healthy subjects who consented and met the inclusion criteria by convenience sampling. The abdominal Aorta wall thickness (AAWT), as well as selected Doppler indices which are: the resistivity and pulsatility indices (RI & PI) of the abdominal aorta (AA) of four hundred and twelve male and female volunteer healthy subjects, were measured sonographically using standard protocols. Data was analyzed using SPSS v 23 and inferential analysis was done with a level of significance set at 5 %. Results : The mean ± SD of the AAWT in the volunteer healthy subjects were 1.54 ± 0.33mm and 1.29 ± 0.32mm in male and female healthy volunteers respectively. The mean ± SD of the RI and PI for male volunteer healthy subjects were 0.81 ± 0.06, and 1.09 ± 0.20. Also, the mean + SD of the RI and PI for female healthy volunteers was 0.59 ± 0.06, and 1.10 ± 0.21 respectively. Conclusion : The reference AAWT, RI and PI in the locality were 1.51 ± 0.33mm, 0.6 ± 0.06 and 1.02 ± 0.19. The RI, PI and AAWT values were higher in males (p >0.005) than in female volunteer healthy subjects.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Reference values of abdominal aorta wall thickness and Doppler indices in a Nigerian population

Okpaleke,

Ugwuanyi,

Ogolodom

et al. 2023

ajhs

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“…In the present study, only the thickness of IMT-bulb was measured. However, it might be that also the flow dynamics in the bifurcation could be a major player in risk assessment, since this characteristic of the carotid artery flow dynamics could be measured by ultrasound as well as by magnetic resonance imaging [18][19][20].…”

Section: Plos Onementioning

confidence: 99%

A comparison of intima media thickness in the common carotid artery, the bulb and plaque area as predictions of incident atherosclerotic events

Lind

2023

PLoS ONE

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Background and aims There is a debate on how to evaluate carotid artery intima-media thickness (IMT). We here compared IMT of the common carotid artery (CCA) and bulb with plaque area regarding incident atherosclerotic disease. Methods In the PIVUS study (age 70 at baseline, 53% women, n = 856), IMT-CCA, IMT-bulb and plaque area were measured at ages 70, 75 and 80 years and these three measurements were used in updated Cox proportional hazard analysis. Results Over 15 years follow-up, 135 individuals experienced a first-time atherosclerotic disease (myocardial infarction or ischemic stroke). IMT-CCA was not significantly related to this composite endpoint (p = 0.10). IMT-bulb was significantly related to the endpoint (p = 0.003), but this relationship was attenuated following adjustment for CVD risk factors (p = 0.02). On the contrary, plaque area was consistently related to incident atherosclerotic disease also following adjustment for CVD risk factors (p<0.001). When added on top of traditional risk factors, both IMT-bulb and plaque area, but not IMT-CCA, improved the discrimination compared to the traditional risk factors (+5.2%, p = 0.0026 for IMT-bulb, +3.8%, p = 0.013 for plaque area and 0.0% for IMT-CCA). Conclusion In elderly subjects, both IMT-bulb and plaque area improved the discrimination regarding incident atherosclerotic disease when added to traditional risk factors. This was not seen for IMT-CCA. IMT-CCA was therefore inferior compared to the other two carotid artery ultrasonographic measurements in this sample of elderly subjects.

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“…In comparison, Doppler ultrasonography measures the average blood flow velocity for the entire IA, which is less precise for IA studies. Human studies comparing both techniques show that WSS measured by Doppler ultrasonography is consistently smaller compared to CFD simulations [ 213 ].…”

Section: Discussionmentioning

confidence: 99%

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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Measuring wall shear stress distribution in the carotid artery in an African population: Computational fluid dynamics versus ultrasound doppler velocimetry

Cited by 7 publications

References 38 publications

Reference values of abdominal aorta wall thickness and Doppler indices in a Nigerian population

Reference values of abdominal aorta wall thickness and Doppler indices in a Nigerian population

A comparison of intima media thickness in the common carotid artery, the bulb and plaque area as predictions of incident atherosclerotic events

Imaging of intracranial aneurysms in animals: a systematic review of modalities

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