Measuring the impact of venous leg ulcers on quality of life

Hareendran, Asha; Bradbury, Andrew W.; Budd, Jeffrey R.; Geroulakos, George; Hobbs, Raymond D.; Kenkre, JE; Symonds, Tara

doi:10.12968/jowc.2005.14.2.26732

Cited by 143 publications

(170 citation statements)

References 12 publications

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“…Excluded studies were published prior to 1990, focused on a single domain of QoL such as pain, 22 were therapy, 23 product, 24,25 or intervention focused 26,27 or developed, evaluated or compared QoL instruments without comparison data from unaffected subjects. [28][29][30] Search strategies.…”

Section: Inclusion / Exclusion Criteriamentioning

confidence: 99%

The impact of chronic venous leg ulcers: a systematic review

et al. 2014

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Section: Inclusion / Exclusion Criteriamentioning

confidence: 99%

The impact of chronic venous leg ulcers: a systematic review

et al. 2014

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“…The socioeconomic consequences of having a chronic wound include severe patient suffering, restricted mobility, loss of employment, and decreased quality of life [7]. Chronic wounds may be sub-classified into vascular ulcers (e.g., venous and arterial ulcers), diabetic ulcers, and pressure ulcers [8]. Most chronic wounds are arrested in a chronic inflammatory state [6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and antibiotic susceptibility of bacteria from acute and chronic wounds in Malaysian subjects

Wong

Manikam

Muniandy

2015

J Infect Dev Ctries

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Introduction: Chronic wounds represent a major health burden worldwide. It has been hypothesized that the polymicrobial nature of wounds plays an important role in their healing process. Thus, a review of pathogen frequency and susceptibility patterns in wounds is necessary to provide appropriate guidelines for antimicrobial usage. Methodology: In this study, microbiota and antimicrobial resistance in both acute and chronic wound patients treated at the University of Malaya Medical Centre, Malaysia, were compared. Wound swabs from 84 patients with acute wounds and 84 patients with chronic wounds were collected. The specimens were cultured using standard microbiological techniques. Isolates were then tested for antibiotic sensitivity with the broth microdilution method. Results: Of 210 pathogenic bacteria isolates, Staphylococcus aureus (49; 23.3%) and Pseudomonas aeruginosa (31; 14.8%) were the most prevalent bacteria found in wounds. Staphylococcus aureus was found significantly more often in patients with chronic wounds (41; 48.8%) than in patients with acute wounds (8; 9.5%), while Staphylococcus epidermidis was found predominantly in acute wounds (15; 17.9%). At the time of study, patients with chronic wounds (58.3%) had received more antibiotic treatments in the past previous 12 months compared with patients with acute wounds (16.7%). In the antibiotic susceptibility test, Staphylococcus spp. revealed highest resistance towards penicillin and ampicillin. Isolates showed no decrease in susceptibility against a number of newly developed antibiotics (linezolid, daptomycin, and tigecycline). Conclusions: Our finding showed that bacteria diversity and antimicrobial-resistant strains are more frequently found in chronic wounds than in acute wounds.

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“…This is particularly important as it may be one of the few ways to distinguish between dressings. The impact of venous ulcers on quality of life has been studied, [15][16][17][18][19][20] but within randomised controlled trials quality of life data were very poor or omitted altogether.…”

Section: External Validity Of Included Trialsmentioning

confidence: 99%

Dressings for venous leg ulcers: systematic review and meta-analysis

2007

BMJ

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Objective To review the evidence of effectiveness of dressings applied to venous leg ulcers. Design Systematic review and meta-analysis. Data sources Hand searches of journals and searches of electronic databases, conference proceedings, and bibliographies up to April 2006; contacts with dressing manufacturers for unpublished studies. Studies reviewed All randomised controlled trials that evaluated dressings applied to venous leg ulcers were eligible for inclusion. Data from eligible studies were extracted and summarised independently by two reviewers using a data extraction sheet. Methodological quality was assessed independently by two reviewers. Results The search strategy identified 254 studies; 42 of these fulfilled the inclusion criteria. Hydrocolloids were no more effective than simple low adherent dressings used beneath compression (eight trials; relative risk for healing with hydrocolloid 1.02, 95% confidence interval 0.83 to 1.28). For other comparisons, insufficient evidence was available to allow firm conclusions to be drawn. None of the dressing comparisons showed evidence that a particular class of dressing healed more ulcers. Some differences existed between dressings in terms of subjective outcome measures and ulcer healing rates. The results were not affected by the size or quality of trials or the unit of randomisation. Insufficient data were available to allow conclusions to be drawn about the relative cost effectiveness of different dressings. Conclusions The type of dressing applied beneath compression was not shown to affect ulcer healing. The results of the meta-analysis showed that applying hydrocolloid dressings beneath compression produced no benefit in terms of ulcer healing compared with applying simple low adherent dressings. No conclusive recommendations can be made as to which type of dressing is most cost effective. Decisions on which dressing to apply should be based on the local costs of dressings and the preferences of the practitioner or patient.

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Measuring the impact of venous leg ulcers on quality of life

Abstract: Disease-specific HRQoL outcome measures should be considered when evaluating treatments for venous leg ulcers.

Cited by 143 publications

References 12 publications

The impact of chronic venous leg ulcers: a systematic review

The impact of chronic venous leg ulcers: a systematic review

Prevalence and antibiotic susceptibility of bacteria from acute and chronic wounds in Malaysian subjects

Dressings for venous leg ulcers: systematic review and meta-analysis

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