Measuring the Hyperelastic Response of Porcine Liver Tissues In-Vitro Using Controlled Cavitation Rheology

Nafo, Wanis; Al-Mayah, Adil

doi:10.1007/s11340-020-00674-6

Cited by 5 publications

(2 citation statements)

References 62 publications

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“…From the mechanical perspective, the concentration of the polymer network in hydrogels controls, to large extent, their mechanical strength allowing them to mimic the mechanics of physiologically loaded tissues [4]. Consequently, due to their availability and relatively low cost, hydrogels have become an attractive option when developing quantitative techniques that measure the mechanics of biological tissues [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel Biomaterials for Drug Delivery: Mechanisms, Design, and Drugs

Nafo¹

2023

Hydrogels - From Tradition to Innovative Platforms With Multiple Applications

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Due to their unique physical and chemical properties, hydrogels have attracted significant attention in several medical fields, specifically, drug delivery applications in which gel-based nanocarriers deliver drug molecules to the region of interest in biological organs. For different drug delivery applications, hydrogel systems can be manipulated to provide passive and/or active delivery. Thus, several drug targeting, loading, and releasing mechanisms have been devised and reported in the literature. This chapter discusses these mechanisms and their efficacy with respect to different drug delivery applications. Furthermore, the drug dosage is dependent on the design and shape of the hydrogel systems, which in turn depend on the route of the drug administration. This chapter covers the types of hydrogel-based products applied via different routes of drug administration. Lastly, this chapter addresses different classifications of delivered drugs including small molecular weight drugs; therapeutic proteins and peptides; and vaccines.

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Section: Introductionmentioning

confidence: 99%

Hydrogel Biomaterials for Drug Delivery: Mechanisms, Design, and Drugs

Nafo¹

2023

Hydrogels - From Tradition to Innovative Platforms With Multiple Applications

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“…Highly strainstiffening materials, such as blood clot, exhibit fracture and do not approach a cavitation limit. VCCE builds on a decade of NICR literature while using an incompressible working fluid and volumetric control of the cavity, thus accessing rich data from the full range of the material response to stretch (Raayai-Ardakani and Cohen, 2019; Nafo and Al-Mayah, 2021). Nafo and Al-Mayah (2021) demonstrate the flexibility of controlled cavity expansion testing to allow for selection of a constitutive model that is well matched to the tissue under test (i.e.…”

Section: Introductionmentioning

confidence: 99%

Elasticity of Whole Blood Clots Measured via Volume Controlled Cavity Expansion

Varner

Sugerman

Rausch

et al. 2023

Preprint

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Measuring and understanding the mechanical properties of blood clots can provide insights into disease progression and the effectiveness of potential treatments. However, several limitations hinder the use of standard mechanical testing methods to measure the response of soft biological tissues, like blood clots. These tissues can be difficult to mount, and are inhomogeneous, irregular in shape, scarce, and valuable. To remedy this, we employ in this work Volume Controlled Cavity Expansion (VCCE), a technique that was recently developed, to measure local mechanical properties of soft materials in their natural environment. Through a highly controlled volume expansion of a water bubble at the tip of an injection needle, paired with simultaneous measurement of the resisting pressure, we obtain a local signature of whole blood clot mechanical response. Comparing this data with predictive theoretical models, we find that a 1-term Ogden model is sufficient to capture the nonlinear elastic response observed in our experiments and produces shear modulus values that are comparable to values reported in the literature. Moreover, we find that bovine whole blood stored at 4°C for greater than 2 days exhibits a statistically significant shift in the shear modulus from 2.53 ± 0.44 kPa on day 2 (N = 13) to 1.23 ± 0.18 kPa on day 3 (N = 14). In contrast to previously reported results, our samples did not exhibit viscoelastic rate sensitivity within strain rates ranging from 0.22 - 21.1 s-1. By surveying existing data on whole blood clots for comparison, we show that this technique provides highly repeatable and reliable results, hence we propose the more widespread adoption of VCCE as a path forward to building a better understanding of the mechanics of soft biological materials.

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Design and evaluation of a novel biopsy needle with hemostatic function

Zhu

Xiao

et al. 2023

Front. Mech. Eng.

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Measuring the Hyperelastic Response of Porcine Liver Tissues In-Vitro Using Controlled Cavitation Rheology

Cited by 5 publications

References 62 publications

Hydrogel Biomaterials for Drug Delivery: Mechanisms, Design, and Drugs

Hydrogel Biomaterials for Drug Delivery: Mechanisms, Design, and Drugs

Elasticity of Whole Blood Clots Measured via Volume Controlled Cavity Expansion

Design and evaluation of a novel biopsy needle with hemostatic function

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