Measuring the effects of night-shift work on cardiac autonomic modulation: an appraisal of heart rate variability metrics

Fink, Anne

doi:10.13075/ijomeh.1896.01560

Cited by 12 publications

(20 citation statements)

References 39 publications

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“…In summary, our results indicate that five weeks of shift work in rats are sufficient to promote cardiac fibrosis, whereby the effects of shift work are exacerbated when animals do not have access to food during work. Based on these data, it is tempting to speculate that the differences we observed between W and WRF shift worker rats may be relevant to explain some of the heterogeneity that has been reported in epidemiological studies of human shift workers (10,12). Importantly, our findings also suggest that lack of food intake during work, which was proposed as a possible intervention to prevent the development of metabolic disorders in shift workers, may not be appropriate to prevent the development of cardiovascular diseases in shift workers.…”

Section: Discussionmentioning

confidence: 76%

“…About 15-20% of the workforce is engaged in some kind of shift work worldwide, and this number is rapidly increasing (1). Over the last decades, many epidemiological studies revealed that shift work affects human health and increases the risk of developing cancer, metabolic disorders, cardiovascular diseases, and mood disorders (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Relevant to this paper, a meta-analysis performed on 17 studies concluded that shift workers exhibit a 40% increased risk of developing cardiovascular diseases than day workers (15).…”

Section: Introductionmentioning

confidence: 99%

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Lack of food intake during shift work alters the heart transcriptome and leads to cardiac fibrosis and inflammation in rats

Trott

Karhadkar

et al. 2021

Preprint

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Many epidemiological studies revealed that shift work is associated with increased risk of cardiovascular diseases. However, the underlying mechanisms remain poorly understood. An experimental model of shift work in rats has been shown to recapitulate the metabolic disorders observed in human shift workers, and used to demonstrate that restricting food consumption outside working hours prevents shift work-associated obesity and metabolic disturbance. Here we used this model to characterize the effects of shift work in the heart. We show that experimental shift work reprograms the heart cycling transcriptome independently of food consumption. While phases of rhythmic gene expression are distributed across the 24-hour day in control rats, they are clustered towards discrete times in shift workers. Additionally, preventing food intake during shift work affects the expression level of hundreds of genes in the heart. Many of them are found in transcriptional signatures associated with pressure overload and cardiac hypertrophy, and encode for components of the extracellular matrix and inflammatory markers. Consistent with this, the heart of shift worker rats not eating during work exhibits fibrosis and is colonized by immune cells. While maintaining food access during shift work has less effects on gene expression, genes found in transcriptional signatures of cardiac hypertrophy remain affected, and the heart of shift worker rats exhibits fibrosis without inflammation. Together, our findings provide insights into how shift work affects cardiac function, and suggest that some interventions aiming at mitigating metabolic disorders in shift workers may have adverse effects on cardiovascular diseases.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Lack of food intake during shift work alters the heart transcriptome and leads to cardiac fibrosis and inflammation in rats

Trott

Karhadkar

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…About 15-20% of the workforce is engaged in some kind of shift work worldwide, and this number is rapidly increasing [1]. Over the last decades, many epidemiological studies revealed that shift work affects human health and increases the risk of developing cancer, metabolic disorders, cardiovascular diseases, and mood disorders [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Relevant to this paper, a metaanalysis performed on 17 studies concluded that shift workers exhibit a 40% increased risk of developing cardiovascular diseases than day workers [15].…”

Section: Introductionmentioning

confidence: 78%

“…A more recent meta-analysis on 173,000 individuals similarly found that shift/night workers have an increased risk of cardiovascular diseases than day workers [ 13 ]. However, there was significant heterogeneity between studies considered in these meta-analyses, and it is still unclear to which extent the quantity, the duration, and the type of shift work impair cardiovascular functions [ 10 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Lack of food intake during shift work alters the heart transcriptome and leads to cardiac tissue fibrosis and inflammation in rats

et al. 2022

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Background Many epidemiological studies revealed that shift work is associated with an increased risk of a number of pathologies, including cardiovascular diseases. An experimental model of shift work in rats has additionally been shown to recapitulate aspects of metabolic disorders observed in human shift workers, including increased fat content and impaired glucose tolerance, and used to demonstrate that restricting food consumption outside working hours prevents shift work-associated obesity and metabolic disturbance. However, the way distinct shift work parameters, such as type of work, quantity, and duration, affect cardiovascular function and the underlying mechanisms, remains poorly understood. Here, we used the rat as a model to characterize the effects of shift work in the heart and determine whether they can be modulated by restricting food intake during the normal active phase. Results We show that experimental shift work reprograms the heart cycling transcriptome independently of food consumption. While phases of rhythmic gene expression are distributed across the 24-h day in control rats, they are clustered towards discrete times in shift workers. Additionally, preventing food intake during shift work affects the expression level of hundreds of genes in the heart, including genes encoding components of the extracellular matrix and inflammatory markers found in transcriptional signatures associated with pressure overload and cardiac hypertrophy. Consistent with this, the heart of shift worker rats not eating during work hours, but having access to food outside of shift work, exhibits increased collagen 1 deposition and displays increased infiltration by immune cells. While maintaining food access during shift work has less effects on gene expression, genes found in transcriptional signatures of cardiac hypertrophy remain affected, and the heart of shift worker rats exhibits fibrosis without inflammation. Conclusions Together, our findings unraveled differential effects of food consumption on remodeled transcriptional profiles of the heart in shift worker rats. They also provide insights into how shift work affects cardiac function and suggest that some interventions aiming at mitigating metabolic disorders in shift workers may have adverse effects on cardiovascular diseases.

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“…While the suprachiasmatic nucleus is the master clock, many organs display a secondary clock that can, in some cases, be asynchronous due to the shift of important cues (e.g., change in feeding time can alter the stomach internal clock [ 141 ]). It has been established that circadian rhythms play an important role in many physiological processes on the ground including sleep cycle [ 142 ], gut microbiota [ 143 ], energy metabolism [ 144 ], heart rate and blood pressure [ 145 , 146 ], and that disturbances in our innate rhythm can lead to obesity [ 147 , 148 , 149 ], diabetes [ 148 ], and fertility complications [ 150 ]. Onboard the international space station (ISS) astronauts can witness 16 sunrises and sunsets every day, however, indoor lighting is used as a mitigating strategy [ 151 ] and simulates a 24-h cycle within the habitat.…”

Section: Outstanding Questionsmentioning

confidence: 99%

Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model

Mortreux

Rosa‐Caldwell

2020

Life

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For decades, scientists have relied on animals to understand the risks and consequences of space travel. Animals remain key to study the physiological alterations during spaceflight and provide crucial information about microgravity-induced changes. While spaceflights may appear common, they remain costly and, coupled with limited cargo areas, do not allow for large sample sizes onboard. In 1979, a model of hindlimb unloading (HU) was successfully created to mimic microgravity and has been used extensively since its creation. Four decades later, the first model of mouse partial weight-bearing (PWB) was developed, aiming at mimicking partial gravity environments. Return to the Lunar surface for astronauts is now imminent and prompted the need for an animal model closer to human physiology; hence in 2018, our laboratory created a new model of PWB for adult rats. In this review, we will focus on the rat model of PWB, from its conception to the current state of knowledge. Additionally, we will address how this new model, used in conjunction with HU, will help implement new paradigms allowing scientists to anticipate the physiological alterations and needs of astronauts. Finally, we will discuss the outstanding questions and future perspectives in space research and propose potential solutions using the rat PWB model.

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Measuring the effects of night-shift work on cardiac autonomic modulation: an appraisal of heart rate variability metrics

Cited by 12 publications

References 39 publications

Lack of food intake during shift work alters the heart transcriptome and leads to cardiac fibrosis and inflammation in rats

Lack of food intake during shift work alters the heart transcriptome and leads to cardiac fibrosis and inflammation in rats

Lack of food intake during shift work alters the heart transcriptome and leads to cardiac tissue fibrosis and inflammation in rats

Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model

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