Measuring the effectiveness of homeopathic care through objective and shared indicators

Leone, Laura; Marchitiello, M; Natilli, Michela; Romano, Maria Francesca

doi:10.1016/j.homp.2011.07.002

Cited by 5 publications

(3 citation statements)

References 22 publications

(6 reference statements)

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“…Among the more controversial papers in this issue is that from Maria Francesca Romano's team at the University of Pisa. 10 They propose a new method for measuring the effectiveness of Homeopathy using standard care indicators collected by the public health authorities. They compare patients receiving Homeopathy with the general population in the same region in terms of drug use and hospitalisation indicators.…”

Section: The Community Perspectivementioning

confidence: 99%

The diversity of endeavour in Homeopathy

Fisher¹

2011

Homeopathy

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Section: The Community Perspectivementioning

confidence: 99%

The diversity of endeavour in Homeopathy

Fisher¹

2011

Homeopathy

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“…Most Unani drugs are safe, but toxicity, including liver injury, has also been observed [5,6]. Furthermore, there are very few scientific attempts to certify and validate the safety of Unani's drugs [7,8]. Therefore, the numerous studies reported have evaluated the hepatoprotective and antioxidant potential of many Unani drugs.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and In-vitro Free Radical Scavenging Activity of Unani Formulation Habb-e-Asgand

Ahemad¹,

Aejazuddin²,

Khan³

2021

JPRI

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Aim: In the present work we aimed to perform phytochemical Screening and In-vitro free radical scavenging activity of Unani formulation Habb-e-asgand. Study Design: The present work was designed to determine the total antioxidant capacity (TAC), Ferrous reducing antioxidant capacity assay (FRAC), DPPH radical scavenging assay, hydroxyl radical scavenging activity, and nitric oxide scavenging assay. Place and Duration of the Study: The present work has been carried out at Ali-allana College of Pharmacy, Akkalkuwa, from February-2020 to November-2020. Methodology: Habb-e-asgand (HEA), a Unani polyherbal drug used in arthritis, gout, and joint pain, is a blend of many herbal medicinal plants. Scientific attempts to test and validate its effectiveness are scarce. The selected Unani formulation was evaluated for DPPH radical scavenging activity, hydroxyl radical scavenging activity, and nitric oxide scavenging assay. The given formulation also evaluated the total antioxidant capacity and the reducing antioxidant capacity of ferrous metals. Results: It was found that DPPH radical scavenging activity of HEA and BHT at a concentration of 100 μg/ml was 95±0.74 and 59±0.94 μg/ml. Hydroxyl radical scavenging activity of HEA, at the concentration of 100μg/ml, was 55±0.64, whereas at the same concentration catechin was 63±0.84 μg/ml. The IC50 value for nitric acid scavenging activity was found to be 49.60±1.57 for HEA, and 186.34 ± 3.28 µg/ml for ascorbic acid. The result obtained from TAC and FRAC activity demonstrates that HEA possessed the highest TAC and FRAC values in comparison to standards catechin and ascorbic acid. Conclusion: From the above results it was concluded that HEA has a potent antioxidant activity. HEA showed moderate to high TAC and FRAC in dose-dependent manner compared to standards catechin and ascorbic acid. HEA shows dose-dependent DPPH and hydroxyl radical scavenging activity. Nitric oxide generation was observed after the incubation of solutions of sodium nitroprusside in PBS at 25°C for 150 min. HEA effectively reduced the generation of nitric oxide.

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“…Most Unani drugs are safe, but toxicity including liver injury has also been observed (Licata et al, 2013;Oberbaum et al, 2012). Moreover, there are very few scientific attempts attesting and validating the safety of Unani drugs (Leone et al, 2011;Rutten, 2011). Therefore, the present study evaluates the hepatoprotective and antioxidative potential of a Unani medicine, known as Habb-e-Asgand.…”

Section: Introductionmentioning

confidence: 99%

Habb-e-Asgand, polyherbal Unani formulation, protects liver and antioxidative enzymes against paracetamol induced hepatotoxicity

Ali

Khan

Chang

et al. 2014

Pharmaceutical Biology

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Context: Habb-e-Asgand, a polyherbal Homeopathy/Unani drug from Hamdard Wakf Laboratory, India, used in arthritis, gout and joint pain, is a mixture of many herbal medicinal plants. Scientific attempts to test and validate its efficacy are meager. Objective: To evaluate the hepatoprotective and antioxidative potential of Habb-e-Asgand against paracetamol toxicity. Materials and methods: Swiss albino male mice (n = 5/group) were treated with Habb-e-Asgand (250 mg/kg, body weight (b.w.) in normal saline orally for 14 days followed by a single dose of paracetamol (400 mg/kg b.w./normal saline) intraperitoneally 24 h before euthanization. We estimated liver function (LFTs) using diagnostic kits, while antioxidant enzymes, cytochrome P450 (CYP) and lipid peroxidation (LPO) were measured using spectrophotometric methods. Results: Paracetamol alone induced LFTs enzymes significantly (p < 0.05 and p < 0.01, 0.001), serum glutamate pyruvate transaminase (SGPT, ∼70%), serum glutamate oxaloacetate transaminase (SGOT, ∼20%), alkaline phosphatase (ALP, ∼20%), total bilirubin (∼30%), CYP activity (∼50%) and LPO (∼45%), while it significantly inhibited the activity of antioxidant enzymes glutathione reductase (GR, ∼35%), glutathione peroxidase (GPx, ∼40%), glutathione S-tranferase (GST, ∼16%), catalase (CAT, ∼84%) and glutathione (GSH, ∼30%) contents. Habb-e-Asgand alone and in combination of paracetamol significantly (p < 0.05, 0.01, 0.001) decreased LFT levels (20-25%), CYP activity (∼45%) and LPO level (∼25%), while it induced antioxidant enzyme activity (GR, ∼15%; GPx, ∼17%; GST, ∼20% and CAT, ∼60%). Discussion: Paracetamol metabolites may be mediating production of reactive oxidant species (ROS) and liver injury, which are attenuated by Habb-e-Asgand antioxidant constituents. Conclusion: Habb-e-Asgand may be used as a prophylaxis for ROS related liver injury.

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Measuring the effectiveness of homeopathic care through objective and shared indicators

Abstract: This paper demonstrates a new methodological approach to assess the effectiveness of a therapeutic modality, without ad-hoc clinical trials. This methodology can be used by public health institutions in which non-conventional medicines are integrated into the public health care system.

Cited by 5 publications

References 22 publications

The diversity of endeavour in Homeopathy

The diversity of endeavour in Homeopathy

Phytochemical Screening and In-vitro Free Radical Scavenging Activity of Unani Formulation Habb-e-Asgand

Habb-e-Asgand, polyherbal Unani formulation, protects liver and antioxidative enzymes against paracetamol induced hepatotoxicity

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