Measuring risk‐taking in mice: balancing the risk between seeking reward and danger

Dent, Claire L.; Isles, Anthony R; Humby, Trevor

doi:10.1111/ejn.12430

Cited by 25 publications

(28 citation statements)

References 41 publications

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“…We assayed basal activity for 2-hours on three consecutive days using a standardised general measure where movement is detected by consecutive breaks of two infrared beams (‘run’) (43). Cdkn1c BACx1 mice were hypoactive relative to their WT littermates, overall making nearly half as many runs in any given session (main effect of GENOTYPE: F 1,47 = 8.49, P = 0.005) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…LMA behaviour was tested using as described (43) with two infra-red beams crossing each cage 30mm from each end and 10mm from the floor of the chamber. Beam breaks were recorded as an indication of activity, using a computer running custom written BBC Basic V6 programmes with additional interfacing by ARACHNID (Cambridge Cognition Ltd, Cambridge, U.K.).…”

Section: Methodsmentioning

confidence: 99%

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Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome

et al. 2016

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Silver Russell Syndrome (SRS) syndrome is an imprinting disorder involving low birth weight with complex genetics and diagnostics. Some rare SRS patients carry maternally inherited microduplications spanning the imprinted genes CDKN1C, PHLDA2, SLC22A18 and KCNQ1, suggesting that overexpression of one of more of these genes contributes to the SRS phenotype. While this molecular alteration is very rare, feeding difficulties are a very common feature of this condition. Given that SRS children also have very low body mass index, understanding the underpinning biology of the eating disorder is important, as well as potential co-occurring behavioural alterations. Here, we report that a mouse model of this microduplication exhibits a number of behavioural deficits. The mice had a blunted perception of the palatability of a given foodstuff. This perception may underpin the fussiness with food. We additionally report hypoactivity, unrelated to anxiety or motoric function, and a deficit in the appropriate integration of incoming sensory information. Importantly, using a second genetic model, we were able to attribute all altered behaviours to elevated expression of a single gene, Cdkn1c. This is the first report linking elevated Cdkn1c to altered behaviour in mice. Importantly, the findings from our study may have relevance for SRS and highlight a potentially underreported aspect of this disorder.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome

et al. 2016

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“…Additionally, neurobiological correlates of impulsivity and sensation seeking have been identified (Buckholtz et al, 2010; Casey, Jones, and Somerville, 2011; Congdon and Canli, 2008; Roberti, 2004), and both traits are commonly measured in non-human subjects (Dent, Isles, and Humby, 2014; Fox, Hand, and Reilly, 2008; Zuckerman, 1984). In contrast, the construct of ASB – particularly rule-breaking forms of ASB – involves evaluating behavior with reference to a socially-defined and culturally-specific set of norms and rules, and is thus considerably more difficult to operationalize in non-human animals.…”

Section: Introductionmentioning

confidence: 99%

Sensation seeking and impulsive traits as personality endophenotypes for antisocial behavior: Evidence from two independent samples

Mann

Engelhardt

Briley

et al. 2017

Personality and Individual Differences

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Sensation seeking and impulsivity are personality traits that are correlated with risk for antisocial behavior (ASB). This paper uses two independent samples of twins to (a) test the extent to which sensation seeking and impulsivity statistically mediate genetic influence on ASB, and (b) compare this to genetic influences accounted for by other personality traits. In Sample 1, delinquent behavior, as well as impulsivity, sensation seeking and Big Five personality traits, were measured in adolescent twins from the Texas Twin Project. In Sample 2, adult twins from the Australian Twin Registry responded to questionnaires that assessed individual differences in Eysenck's and Cloninger's personality dimensions, and a structured telephone interview that asked participants to retrospectively report DSM-defined symptoms of conduct disorder. Bivariate quantitative genetic models were used to identify genetic overlap between personality traits and ASB. Across both samples, novelty/sensation seeking and impulsive traits accounted for larger portions of genetic variance in ASB than other personality traits. We discuss whether sensation seeking and impulsive personality are causal endophenotypes for ASB, or merely index genetic liability for ASB.

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“…При сравнительном анализе эффекта различ-ных запахов хищника на домовую мышь выявлен бо-лее выраженный ответ мышей на хемосигналы кошки по сравнению, например, с запахом змеи [21], крысы [22] и лисьим феромоном триметил-тиазолином (ТМТ) в ес-тественной концентрации [23].…”

Section: Discussionunclassified

Predator odor induces genome instability in the mouse bone marrow cells

Glinin

Сергеевич²,

Starshova

et al. 2017

Ecological genetics

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Background. Long coevolution of prey and predator species of mammals creates specific mechanisms of their interaction, e. g. prey’s innate behavior aversive to the predator odor. However, little is known about genetic responses in the prey organism. We assessed genome instability of the bone marrow cells in mice affected by the cat’s odor influence, and proposed pathway of such action. Materials and methods. CBA mouse males were exposed to volatiles from adult cat urine for 2 or 24 hours. To estimate the genetic effect, ana-telophase method of chromosome aberration analysis and comet assay were used. The level of corticosterone was also measured after the exposure for 30 or 60 minutes. Results. The exposure to cat’s urine volatiles for 2 hours induced damage of DNA in bone marrow cells of the mouse males as was shown by the DNA comet analysis. The exposure for 24 hours elevated the frequency of chromosome aberrations in mitotically dividing cells at ana-telophase stage. No significant changes were found in the level of corticosterone in the peripheral blood. Conclusion. We have shown that volatile chemosignals from predator’s urine induce genomic instability in bone marrow cells of a prey. The hormonal pathway of such influence is still unknown. Intraorganismic paths leading to genome damage are discussed as well as far consequences of discovered effects.

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Measuring risk‐taking in mice: balancing the risk between seeking reward and danger

Cited by 25 publications

References 41 publications

Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome

Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome

Sensation seeking and impulsive traits as personality endophenotypes for antisocial behavior: Evidence from two independent samples

Predator odor induces genome instability in the mouse bone marrow cells

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