Measuring quality of life in people referred for specialist care of acne: Comparing generic and disease-specific measures

Klassen, Anne F.; Newton, J.O.; Mallon, E.

doi:10.1067/mjd.2000.105507

Cited by 113 publications

(92 citation statements)

References 21 publications

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“…In agreement with the limited previous studies using EQ-5D, impairment was found in HS, psoriasis, pimples and AE [8,16,38,39,40,41,42,43]. Greater impairment was however found in the Swedish population having hand rash [16].…”

Section: Discussionsupporting

confidence: 79%

Self-Reported Skin Morbidities and Health-Related Quality of Life: A Population-Based Nested Case-Control Study

et al. 2014

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Background: Impaired dermatological health-related quality of life (HRQoL) has been observed in hospital-based studies, but little is known on a population-based level. Objective: To investigate self-reported dermatological HRQoL in the general population. Methods: Hidradenitis suppurativa, psoriasis, pimples, hand rash or atopic eczema were identified using questionnaires in a 15,177 person population sample. A nested case-control study of 180 cases and 259 controls was made using the Dermatology Life Quality Index (DLQI), Skindex-29 and EQ-5D. Results: Cases had higher scores in DLQI and Skindex-29 and a lower score in EQ-5D, suggesting lower HRQoL. Adjusting for age and sex, the differences in Skindex-29 and DLQI were significant (p < 0.001). Conclusions: Persons with self-reported skin morbidity had lower HRQoL than the general population. The impairment is not as significant as in studies of hospital-based cases, but considering the high prevalence of skin diseases it may still represent a significant burden of disease on society in aggregate.

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Section: Discussionsupporting

confidence: 79%

Self-Reported Skin Morbidities and Health-Related Quality of Life: A Population-Based Nested Case-Control Study

et al. 2014

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“…Comparison of our SF-36 results with other dermatological diseases (Fig. S1 1 ) (23)(24)(25)(26)(27), shows that on the PCS scale JEB and RDEB have one of the worst recorded HRQoL score, only to be surpassed by psoriatic arthritis (26). EBS has a HRQoL score similar to atopic dermatitis, and DDEB similar to psoriasis (26).…”

Section: Discussionmentioning

confidence: 99%

Health-related Quality of Life in Epidermolysis Bullosa: Validation of the Dutch QOLEB Questionnaire and Assessment in the Dutch Population

Yuen¹,

Frew²,

Veerman³

et al. 2014

Acta Derm Venerol

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Wing Yan Yuen, Department of Dermatology, University Medical Center Groningen, Hanzeplein 1, NL-9700 RB Groningen, The Netherlands. E-mail: w.y.yuen@umcg.nl Epidermolysis bullosa (EB) consists of a spectrum of heritable trauma-induced blistering diseases of skin and mucous membranes (1). Many subtypes exist, and their clinical severity is variable, ranging from an occasional palmoplantar blister to childhood lethality (1). The health-related quality of life (HRQoL) is the impact of a disease on the physical, psychological, and social health of a patient (2). Defining HRQoL in EB patients is important in patient care and management (3). Furthermore, in recent years more focus has been placed on finding specific treatments for EB and measuring HRQoL can help in assessing the efficacy of these new treatment modalities (4, 5). Also, measuring and comparing HRQoL to other diseases can help assign funding to this rather unknown and rare disorder (4, 6). Measuring HRQoL is complicated by the wide range of phenotypes in EB, which all have their own clinical severity (3). Several studies have focused on qualitatively describing the impact of EB on patients' lives (7-11). Quantitative measurement of HRQoL has been performed using both generic and dermatology-specific instruments in EB patients (6, 12-15). However, due to ceiling effects and content validity issues of these instruments, the accuracy of the measurements is questionable. It has been hypothesised that, especially in the more severe EB subtypes, there has been an overestimation of the HRQoL (3). To overcome these problems, Frew et al. (3) developed and validated an EB-specific HRQoL measurement tool for older children and adults that can be used across all EB subtypes, called the QOLEB (quality of life in EB). Translation of the QOLEB, which was created and validated in English in Australia, to other cultures and languages may provide reliable comparisons of HRQoL in EB and the efficacy of clinical interventions across different countries (3). The aim of this study was to develop a validated and reliable QOLEB in Dutch, and to assess HRQoL in Dutch EB patients. MATERIALS AND METHODSThis study was performed at the Center for Blistering Diseases at the University Medical Center Groningen, which is the single national referral centre for EB in the Netherlands. Ethical approval was granted by the Medical Ethical Committee of the University Medical Center Groningen in the Netherlands. A signed consent form was obtained from all participating patients. Study measurement toolsThe English QOLEB is a validated and reliable adult EBspecific HRQoL tool consisting of a 17-item questionnaire, and it was developed by 2 of the authors (JWF and DFM) (3). The QOLEB measures 2 factors: functioning (questions 1-7, 9-10, 12-13, 15) and emotions (question 8, 11, 14, 16-17). For each question 4 optional answers exist that are scored from 0 to 3 points, in which a higher score represents a worse HRQoL. The functioning scale ranged from 0-36, the emotions scale from 0-15, and the ove...

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“…Several studies of depression and social anxiety assessment have been conducted in patients with acne (14)(15)(16). Anxiety may be worsened if there is lack of response to acne treatment.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Temperament and Character Profile with Anxiety and Depression in Patients with Acne

Öztürk¹,

Orhan²,

Özer³

et al. 2013

Balkan Med J

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Background: Acne is the most common skin disease, affecting nearly 85% of the population as well as their lives. Acne can severely affect social and psychological functioning. Patients with acne may have anxiety, depression, decreased self-esteem, interpersonal difficulties, unemployment, social withdrawal, and even suicidal intent.Aims: The aim of this study was to evaluate the temperament and character inventory (TCI) of patients with acne and to compare the results with those of healthy controls.Study Design: Case-control study Methods:The study population consisted of 47 patients with acne, and 40 healthy control subjects. All participants were instructed to complete a selfadministered 240-item TCI and the Hospital Anxiety and Depression Scale.Results: In this study, the scores for the temperament properties Worry and pessimism (HA1) and Dependence (RD4) and the character properties Social acceptance (C1) and Integrated conscience (C5) were found to be higher in acne patients than in healthy controls (p<0.05). Compared to the controls, depression and anxiety scores were found to be markedly higher in the patients with acne. Acne type correlated positively with the Disorderliness (NS4) subscale of Novelty seeking (NS) and anxiety. Additionally, acne type correlated negatively with the Attachment (RD3) subscale of Reward Dependence (RD), with the Transpersonal identification (ST2) and Spiritual acceptance (ST3) subscales of Self-Trancendence (ST), and with the Compassion (C4) subscale of Cooperativeness (C). Conclusion:Studies in this area may lead to the development of specific and focused interventions for TCI in patients with acne vulgaris. We suggest that the evaluation and treatment of acne should also include psychosomatic approaches in clinical practice.

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Measuring quality of life in people referred for specialist care of acne: Comparing generic and disease-specific measures

Cited by 113 publications

References 21 publications

Self-Reported Skin Morbidities and Health-Related Quality of Life: A Population-Based Nested Case-Control Study

Self-Reported Skin Morbidities and Health-Related Quality of Life: A Population-Based Nested Case-Control Study

Health-related Quality of Life in Epidermolysis Bullosa: Validation of the Dutch QOLEB Questionnaire and Assessment in the Dutch Population

Assessment of Temperament and Character Profile with Anxiety and Depression in Patients with Acne

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