Measuring Pulsatile Forces on the Human Cranium

Goldberg, Cory S.; Antonyshyn, Oleh; Midha, Rajiv; Fialkov, Jeffrey A.

doi:10.1097/00001665-200501000-00027

Cited by 8 publications

(9 citation statements)

References 16 publications

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“…Both the CPC and the biocomposite set to form a hard solid within 10 min of injection, which offers the advantage of wound closure shortly after placing the material. CPC showed extensive cracking after setting, which has been reported for CPCs in previous studies [13] and has been attributed to pulsatile forces from the dura that can drive systolic normal and tangential stresses of 54.2 kPa and 345.4 kPa, respectively [15]. In order to mitigate complications associated with Norian R CRS observed in a pediatric long-term retrospective study, use of only moderate amounts of the material has been recommended for onlay (not inlay or full calvarial thickness) applications [40].…”

Section: Discussionsupporting

confidence: 66%

Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects

et al. 2012

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Craniofacial injuries can result from trauma, tumor ablation, or infection and may require multiple surgical revisions. To address the challenges associated with treating craniofacial bone defects, an ideal material should have the ability to fit complex defects (i.e. be conformable), provide temporary protection to the brain until the bone heals, and enhance tissue regeneration with the delivery of biologics. In this study, we evaluated the ability of injectable lysine-derived polyurethane (PUR)/allograft biocomposites to promote bone healing in critical-size rabbit calvarial defects. The biocomposites exhibited favorable injectability, characterized by a low yield stress to initiate flow of the material and a high initial viscosity to minimize the adverse phenomena of extravasation and filter pressing. After injection, the materials cured within 10-12 min to form a tough, elastomeric solid that maintained mechanical integrity during the healing process. When injected into a critical-size calvarial defect in rabbits, the biocomposites supported ingrowth of new bone. The addition of 80 µg mL(-1) recombinant human bone morphogenetic protein-2 (rhBMP-2) enhanced new bone formation in the interior of the defect, as well as bridging of the defect with new bone. These observations suggest that injectable reactive PUR/allograft biocomposites are a promising approach for healing calvarial defects by providing both mechanical stability as well as local delivery of rhBMP-2.

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Section: Discussionsupporting

confidence: 66%

Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects

et al. 2012

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“…2B), which is a target performance value for the BGS. 6,28 In vivo resorption appeared to be almost complete by 6 weeks and likely was a consequence of enzymatic and/or cellular interactions. 29 Furthermore, biodegradability of TyrPC-based scaffolds appeared to match the bone formation rate (*2 mm/day).…”

Section: Discussionmentioning

confidence: 99%

“…3,5 In addition, the bone substitute must have adequate mechanical strength during bone healing, including nonload-bearing zones of the cranium where cyclic stresses occur due to dural pulsation. 6 A new class of tyrosine-derived polycarbonates (TyrPCs) has been developed that is composed of desaminotyrosyltyrosine alkyl ester (DTR), desaminotyrosyl-tyrosine (DT), and poly(ethylene glycol) (PEG). By combining these three monomers, the resulting terpolymers can provide precise control of physical, chemical, biomechanical, and biological properties requisite for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration in a Rabbit Critical-Sized Calvarial Model Using Tyrosine-Derived Polycarbonate Scaffolds

Kim

Magno

Waters

et al. 2012

Tissue Engineering Part A

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Porous three-dimensional tyrosine-derived polycarbonate (TyrPC) scaffolds with a bimodal pore distribution were fabricated to mimic bone architecture using a combination of salt-leaching and phase separation techniques. TyrPC scaffolds degraded in register with bone regeneration during the 6-week study period and compressive moduli of the scaffolds were maintained >0.5 MPa at 6 weeks of incubation in PBS at 37 °C. The TyrPC scaffolds either unsupplemented or supplemented with recombinant human bone morphogenetic protein-2 (rhBMP-2) were implanted in a rabbit calvarial critical-sized defect (CSD) model and the TyrPC scaffolds treated with rhBMP-2 or TyrPC coated with calcium phosphate scaffold alone promoted bone regeneration in a rabbit calvarial CSD at 6 weeks postimplantation. A synthetic TyrPC polymeric scaffold either without a biological supplement or with a minimal dose of rhBMP-2 induced bone regeneration comparable to a commercially available bone graft substitute in a nonrodent CSD animal model.

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“…The design of a bone substitute for cranioplasty procedures is especially daunting as a consequence of the cyclic stresses caused by pulsation of the brain 3. Furthermore, it is equally important that cranioplasty materials do not fragment, particulate, and incite an inflammatory reaction or cause an infection.…”

Section: Introductionmentioning

confidence: 99%

Fiber‐reinforced calcium phosphate cement formulations for cranioplasty applications: A 52‐week duration preclinical rabbit calvaria study

Kim

McBride

Fulmer³

et al. 2011

J Biomed Mater Res

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The in vivo tissue response to a newly developed fiber-reinforced calcium phosphate cement (CPC) formulation was assessed using a well-established rabbit calvarial defect model. Bilateral subcritical sized (8-mm diameter) defects were surgically created in the parietal bones of each rabbit (a total of 48 rabbits), and randomized to be filled with either the new fiber-reinforced formulation, a conventional CPC (positive control), or left unfilled (negative control). The implant sites were subsequently retrieved after 12, 24, and 52 weeks postsurgery. Each specimen, including the parietal bone craniotomy and underlying brain, were recovered at necropsy and the tissue responses were assessed by histology. The resulting histological slides indicated that there was no evidence of severe inflammatory responses or osteolysis. The data showed new dural and pericranial bone formation along the implants, as well as excellent bone-to-implant interfaces in all of the CPC-filled defects. These results suggest that the biologic response to the new fiber-reinforced CPC formulations and conventional nonreinforced CPC are very similar, and both demonstrate excellent biocompatibility as well as an overall osteophylic response.

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Measuring Pulsatile Forces on the Human Cranium

Cited by 8 publications

References 16 publications

Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects

Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects

Bone Regeneration in a Rabbit Critical-Sized Calvarial Model Using Tyrosine-Derived Polycarbonate Scaffolds

Fiber‐reinforced calcium phosphate cement formulations for cranioplasty applications: A 52‐week duration preclinical rabbit calvaria study

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