Objectives: this study amid to identify and study most properties of the specific health-related quality-of-life (HRQoL) in men with prostate cancer, and to find out relationships among distribution of an overall assessment quality of life improvement and socio-demographic characteristics, as well as with general information variables. Regarding Specific QoL, overall results shows moderate assessment, but some domains are reported worse assessment than others specially (sexual confidence, marital affection and regret) domains, other domains accounted moderate responses and those are (urinary control, masculine and self-esteem, heath worry, cancer control, informed decision and outlook), while (sexual intimacy and PSA concern) domains are accounted high responding, therefore, prostate cancer patients have instability of their daily life cycle, within a moderate level. In