Measuring prefrontal cortical activity during dual task walking in patients with Parkinson’s disease: feasibility of using a new portable fNIRS device

Nieuwhof, Freek; Reelick, Miriam F.; Maidan, Inbal; Mirelman, Anat; Hausdorff, Jeffrey M.; Rikkert, Marcel G M Olde; Bloem, Bastiaan R.; Muthalib, Makii; Claassen, Jurgen A.H.R.

doi:10.1186/s40814-016-0099-2

Cited by 70 publications

(118 citation statements)

References 62 publications

(78 reference statements)

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“…Following the development of the novel wearable and portable fNIRS devices, the past few years have seen the first studies investigating the feasibility of using fNIRS with freely moving participants. These studies have been conducted on healthy adults 43,[98][99][100][101][102][103]106 and on patients with neurological deficits (e.g., Parkinson's disease 13,100 and mild cognitive impairments 14 ), and demonstrated the ability of fNIRS of measuring brain hemodynamics and oxygenation in response to cognitive tasks performed while they are moving freely. It is even more exciting to see that these investiga-tions can be performed outside the laboratory and in everyday life situations, as shown by the works in Refs.…”

Section: Overview Of Novel Applications Of Fnirsmentioning

confidence: 99%

The present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience

Pinti

Tachtsidis

Hamilton

et al. 2018

Annals of the New York Academy of Sciences

581

575

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The past few decades have seen a rapid increase in the use of functional near-infrared spectroscopy (fNIRS) in cognitive neuroscience. This fast growth is due to the several advances that fNIRS offers over the other neuroimaging modalities such as functional magnetic resonance imaging and electroencephalography/magnetoencephalography. In particular, fNIRS is harmless, tolerant to bodily movements, and highly portable, being suitable for all possible participant populations, from newborns to the elderly and experimental settings, both inside and outside the laboratory. In this review we aim to provide a comprehensive and state-of-the-art review of fNIRS basics, technical developments, and applications. In particular, we discuss some of the open challenges and the potential of fNIRS for cognitive neuroscience research, with a particular focus on neuroimaging in naturalistic environments and social cognitive neuroscience.

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Section: Overview Of Novel Applications Of Fnirsmentioning

confidence: 99%

The present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience

Pinti

Tachtsidis

Hamilton

et al. 2018

Annals of the New York Academy of Sciences

581

575

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“…Of the 46 included articles, 13 included a mix of younger and older participants (Heilbronner and Münte, 2013;Ohsugi et al, 2013;Beurskens et al, 2014;Müller et al, 2014;Oboshi et al, 2014;Hernandez et al, 2016;Bierre et al, 2017;Mirelman et al, 2017;Rosso et al, 2017;Hawkins et al, 2018) whereas 29 included only older adults (Doi et al, 2013;Heinzel et al, 2013Heinzel et al, , 2015Niu et al, 2013;Clark et al, 2014;Vermeij et al, 2014;Dupuy et al, 2015;Holtzer et al, 2015Holtzer et al, , 2016Holtzer et al, , 2017aHoltzer et al, ,b, 2018aLaguë-Beauvais et al, 2015;Al-Yahya et al, 2016;Maidan et al, 2016Maidan et al, , 2017Mahoney et al, 2016;Nieuwhof et al, 2016;Osofundiya et al, 2016;Takeuchi et al, 2016;Uemura et al, 2016;Yeung et al, 2016a,b;Chen et al, 2017;Huppert et al, 2017;Verghese et al, 2017;Yap et al, 2017;Halliday et al, 2018;Katzorke et al, 2018;Lucas et al, 2018;Mori et al, 2018;Thumm et al, 2018). Moreover, 26 studies included only cognitively normal participants…”

Section: General Descriptionmentioning

confidence: 99%

Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Udina

Avtzi

Durdurán

et al. 2020

Front. Aging Neurosci.

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The integrity of the frontal areas of the brain, specifically the prefrontal cortex, are critical to preserve cognition and mobility in late life. Prefrontal cortex regions are involved in executive functions and gait control and have been related to the performance of dual-tasks. Dual-task performance assessment may help identify older adults at risk of negative health outcomes. As an alternative to neuroimaging techniques that do not allow assessment during actual motion, functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive technique that can assess neural activation through the measurement of cortical oxygenated and deoxygenated hemoglobin levels, while the person is performing a motor task in a natural environment as well as during cognitive tasks. The aim of this review was to describe the use of fNIRS to study frontal lobe hemodynamics during cognitive, motor and dual-tasks in older adults. From the 46 included publications, 20 studies used only cognitive tasks, three studies used motor tasks and 23 used dual-tasks. Our findings suggest that fNIRS detects changes in frontal activation in older adults (cognitively healthy and mild cognitive impairment), especially while performing cognitive and dual-tasks. In both the comparison between older and younger adults, and in people with different neurological conditions, compared to healthier controls, the prefrontal cortex seems to experience a higher activation, which could be interpreted in the context of proposed neural inefficiency and limited capacity models. Further research is needed to establish standardized fNIRS protocols, study the cerebral hemodynamic in different neurological and systemic conditions that might influence cortical activation and explore its role in predicting incident health outcomes such as dementia.

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“…fNIRS, performed using different walking tasks, highlights the role of the PFC either during postural control of PD patients or during the emergency of FOG symptoms. 51 Mahoney et al 52 were the first in studying patients with Parkinsonian syndromes, where an increase of PFC oxyHb was associated with improvement in postural instability. Furthermore, Maidan et al 50 described the hyperactivity of the Brodmann's Area 10 (a prefrontal region involved in the motor planning) occurring before FOG during anticipated turns.…”

Section: What Fnirs Teaches Us About Gait Control In Neurological Patmentioning

confidence: 99%

Near-Infrared Spectroscopy in Gait Disorders: Is It Time to Begin?

Gramigna

Pellegrino

Cerasa

et al. 2017

Neurorehabil Neural Repair

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Walking is a complex motor behavior with a special relevance in clinical neurology. Many neurological diseases, such as Parkinson's disease and stroke, are characterized by gait disorders whose neurofunctional correlates are poorly investigated. Indeed, the analysis of real walking with the standard neuroimaging techniques poses strong challenges, and only a few studies on motor imagery or walking observation have been performed so far. Functional near-infrared spectroscopy (fNIRS) is becoming an important research tool to assess functional activity in neurological populations or for special tasks, such as walking, because it allows investigating brain hemodynamic activity in an ecological setting, without strong immobility constraints. A systematic review following PRISMA guidelines was conducted on the fNIRS-based examination of gait disorders. Twelve of the initial yield of 489 articles have been included in this review. The lesson learnt from these studies suggest that oxy-hemoglobin levels within the prefrontal and premotor cortices are more sensitive to compensation strategies reflecting postural control and restoration of gait disorders. Although this field of study is in its relative infancy, the evidence provided encourages the translation of fNIRS in clinical practice, as it offers a unique opportunity to explore in depth the activity of the cortical motor system during real walking in neurological patients. We also discuss to what extent fNIRS may be applied for assessing the effectiveness of rehabilitation programs.

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Measuring prefrontal cortical activity during dual task walking in patients with Parkinson’s disease: feasibility of using a new portable fNIRS device

Cited by 70 publications

References 62 publications

The present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience

The present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience

Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Near-Infrared Spectroscopy in Gait Disorders: Is It Time to Begin?

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