“…One of these elements is “Health” (Health-SigQOLM), which consists of nine domains measured through 33 items. Originally designed to holistically assess the quality of life (QOL) and well-being of individuals within a two-week period [ 9 ], SigQOLM primarily focuses on health-related quality of life (HRQOL), reflecting its significance as a determinant of overall QOL and well-being. However, previous publications have predominantly focused on item and framework development, lacking clinical evidence for the health element.…”