Measuring Orthopedic Plate Strain to Track Bone Healing Using a Fluidic Sensor Read via Plain Radiography

Rajamanthrilage, Apeksha C.; Arifuzzaman, Md; Millhouse, Paul W.; Pace, Thomas B.; Behrend, Caleb; DesJardins, John D.; Anker, Jeffrey N.

doi:10.1109/tbme.2021.3092291

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…This type of approach works well for fluidic channels. [ 80 ] However, it was found that the contact friction from a swollen hydrogel prevents smooth motion, even in low friction coefficient PTFE tubes, and inhibits swelling/deswelling at least on the scale of hours. Thus, in the design presented, the hydrogel diameter is less than the casing: effectively the hydrogel is free to move in a liquid sheath held in the casing and fixed only at one location by the pinning wire.…”

Section: Resultsmentioning

confidence: 99%

X‐Ray Visualized Sensors for Peritoneal Dialysis Catheter Infection

Kiridena

Wijayaratna

Levon

et al. 2023

Adv Funct Materials

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Peritonitis is a common complication for patients with end-stage renal disease undergoing peritoneal dialysis (PD) and is a direct cause or contributor in >15% deaths in PD patients. Since early detection is key to treatment, patients and their care teams need rapid, on-site diagnostics. A hydrogelbased peritoneal fluid pH sensor attached to a peritoneal dialysis catheter is developed to measure local acidosis indicative of peritoneal infections for early detection and monitoring of infections using X-ray imaging. The sensor comprises a polyacrylic acid hydrogel with embedded radiopaque markers enclosed in a polymer casing; contraction of the hydrogel in response to acidic pH is evident from the radiographically measured marker position. The sensor has a pH 4-8 response range; between pH 6.5 and 7.5 it responds linearly with a slope of 14% pH 7 length per pH unit, and about 1% length precision. The sensor is attached to a catheter and implanted in a rat peritoneum. Results in awake rats show a rapid pH drop during infection not observed in systemic C-reactive proteins (CRP) levels nor in the uninfected control animal, with negligible drift over 2 weeks. To our knowledge, this is the first report of an in vivo chemically responsive hydrogel sensor.

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Section: Resultsmentioning

confidence: 99%

X‐Ray Visualized Sensors for Peritoneal Dialysis Catheter Infection

Kiridena

Wijayaratna

Levon

et al. 2023

Adv Funct Materials

Self Cite

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“…This concept is based on in situ strain sensors that quantitatively measure the strain on an orthopaedic plate while weight-bearing, thus representing healed bone strength. To measure the applied load on the plate, Pelham et al 26 introduced a cantilevered indicator pin, and Rajamanthrilage et al 27 introduced a hydraulic sensor.…”

Section: Mechanical Evaluationmentioning

confidence: 99%

“…This concept is based on in situ strain sensors that quantitatively measure the strain on an orthopaedic plate while weightbearing, thus representing healed bone strength. To measure the applied load on the plate, Pelham et al 26 introduced a cantilevered indicator pin, and Rajamanthrilage et al 27 introduced a hydraulic sensor. FEA uses computed tomographic (CT) imaging to develop a virtual model of the bone and then subject it to simulated mechanical testing to assess the rigidity of the callus 28 , which has been directly correlated with fracture site healing [28][29][30] .…”

Section: Plate Pressure Sensormentioning

confidence: 99%

Assessment of Bone Healing

Shariyate,

Kheir,

Caro

et al. 2023

Journal of Bone and Joint Surgery

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Bone healing is commonly evaluated by clinical examination and serial radiographic evaluation. Physicians should be mindful that personal and cultural differences in pain perception may affect the clinical examination. Radiographic assessment, even with the Radiographic Union Score, is qualitative, with limited interobserver agreement.Physicians may use serial clinical and radiographical examinations to assess bone healing in most patients, but in ambiguous and complicated cases, they may require other methods to provide assistance in decision-making.In complicated instances, clinically available biomarkers, ultrasound, and magnetic resonance imaging may determine initial callus development. Quantitative computed tomography and finite element analysis can estimate bone strength in later callus consolidation phases.As a future direction, quantitative rigidity assessments for bone healing may help patients to return to function earlier by increasing a clinician’s confidence in successful progressive healing.

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“…At the same time, it is also necessary to strengthen the communication and mutual supervision between medical and nursing personnel to ensure the harmonious and stable development of the doctor-patient relationship. In addition, it should also pay attention to the differentiated needs between different regions and the prediction of the change trend of the patient's condition within the hospital, so as to achieve the purpose of alleviating the severe illness and rehabilitation treatment after the disease by adjusting the clinical nursing measures reasonably and effectively [17].…”

Section: Application Of Ai Technology In Orthopedic Clinical Nursing ...mentioning

confidence: 99%

Optimal allocation strategy of orthopedic clinical nursing services based on artificial intelligence

Yuan

2023

Second International Conference on Biomedical and Intelligent Systems (IC-BIS 2023)

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Measuring Orthopedic Plate Strain to Track Bone Healing Using a Fluidic Sensor Read via Plain Radiography

Cited by 5 publications

References 39 publications

X‐Ray Visualized Sensors for Peritoneal Dialysis Catheter Infection

X‐Ray Visualized Sensors for Peritoneal Dialysis Catheter Infection

Assessment of Bone Healing

Optimal allocation strategy of orthopedic clinical nursing services based on artificial intelligence

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