Measuring of quality of life in autoimmune blistering disorders in Poland. Validation of disease – specific Autoimmune Bullous Disease Quality of Life (ABQOL) and the Treatment Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaires

Kalińska-Bienias, Agnieszka; Jakubowska, Beata; Kowaléwski, Cezary; Murrell, Dédée F.; Woźniak, Katarzyna

doi:10.1016/j.advms.2016.07.002

Cited by 25 publications

(42 citation statements)

References 21 publications

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“…So far there are no data connected with the role of IL-31 in development of itch in a course of autoimmune blistering diseases as well as itch intensity in a course of dermatitis herpetiformis. Moreover there are scarce data connected with itch intensity in a course of bullous pemphigoid [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

Kulczycka-Siennicka

Cynkier

Waszczykowska

et al. 2017

BioMed Research International

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Itch which is one of the major, subjective symptoms in a course of bullous pemphigoid and dermatitis herpetiformis makes those two diseases totally different than other autoimmune blistering diseases. Its pathogenesis is still not fully known. The aim of this research was to assess the role of IL-31 in development of itch as well as to measure its intensity. Obtained results, as well as literature data, show that lower concentration of IL-31 in patients' serum may be correlated with its role in JAK/STAT signaling pathway which is involved in development of autoimmune blistering disease. Intensity of itch is surprisingly huge problem for the patients and the obtained results are comparable with results presented by atopic patients.

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Section: Introductionmentioning

confidence: 99%

The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

Kulczycka-Siennicka

Cynkier

Waszczykowska

et al. 2017

BioMed Research International

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“…12,13 However, most of these studies have focused on pemphigus 12,13 or BP patients are analyzed along with other AIBD. 14 To the best of our knowledge, only Kouris et al have specifically reported on BP's impact on QoL. In their series of 57 patients with BP, they found that patients had higher scores for depression compared to sex-and gender-matched healthy controls, but did not find any difference for anxiety.…”

Section: Quality Of Life In Patients With Bullous Pemphigoidmentioning

confidence: 93%

<p>Depression and Anxiety in Patients with Bullous Pemphigoid: Impact and Management Challenges</p>

Kluger¹,

Pankakoski²,

Panelius³

2020

CCID

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Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. It is also associated with high mortality and poor prognosis due to advanced age of the patients and coexisting comorbidities. There is a dearth of data in the literature regarding depression and anxiety among those patients. The objective of this brief review is to discuss the intertwining relationship between depression and anxiety with bullous pemphigoid.

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“…Pruritus is one of the main symptoms, as many patients report itching, often very severe . Moreover, pruritus may negatively impact the quality of life in autoimmune blistering diseases as measured by the disease‐specific Autoimmune Bullous Disease Quality of Life Questionnaire . The mechanism of pruritus in BP remains unclear; however, the role of the increased serum IgE level cannot be excluded …”

Section: Introductionmentioning

confidence: 99%

“…1,2 Moreover, pruritus may negatively impact the quality of life in autoimmune blistering diseases as measured by the disease-specific Autoimmune Bullous Disease Quality of Life Questionnaire. 3 The mechanism of pruritus in BP remains unclear; however, the role of the increased serum IgE level cannot be excluded. 4 Severity of pruritus is traditionally assessed by the visual analogue scale (VAS), which is the most commonly used tool in pruritic disorders.…”

Section: Introductionmentioning

confidence: 99%

Actigraphy‐measured nocturnal wrist movements and assessment of sleep quality in patients with bullous pemphigoid: a pilot case–control study

et al. 2019

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Summary Background Bullous pemphigoid (BP) is a distressing autoimmune bullous disease strongly associated with severe pruritus; however, data concerning pruritus in BP are still scarce. No clinical research evaluating the effect of BP on sleep quality has been conducted. Aim To evaluate the intensity of pruritus measured by nocturnal wrist movements (NWMs) and the sleep quality in patients with BP using actigraphy in comparison with nonpruritic healthy controls (HCs) with subsequent correlations with an itch visual analogue scale (VAS) as a subjective measure, disease severity [Bullous Pemphigoid Disease Area Index (BPDAI), urticaria/erythema, erosions/blisters] and serum total IgE level. Methods In total, 31 patients with newly diagnosed BP (mean ± SD age 75.4 ± 12.3 years) and 40 nonpruritic HCs (age 73.5 ± 11.7 years) were recruited. All participants wore a sleep monitor (ActiSleep+) on the dominant wrist. Results For patients with BP, median VAS score was 5.5 and median BPDAI was 43 (urticaria/erythema BPDAI was 16, erosions/blisters BPDAI was 29). Scratching, defined as bouts of NWMs, was significantly (P < 0.001) more intensive in patients with BP than in controls. Characteristic of BP was that scratching bouts corresponded with the slowest wrist movements. There were no correlations with VAS, BPDAI or total IgE level. Compared with HCs, patients with BP presented significant (P < 0.001) sleep disturbances, as determined by sleep efficiency, waking after sleep onset and average duration of awakening, and these were strongly correlated with urticaria/erythema BPDAI. Conclusion Nocturnal wrist movements measured by actigraphy are more intensive in patients with BP than in nonpruritic HCs, and characteristically slow movements. Actigraphy method showed very low sleep quality in patients with BP, thus severity of BP has a negative impact on sleep.

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Measuring of quality of life in autoimmune blistering disorders in Poland. Validation of disease – specific Autoimmune Bullous Disease Quality of Life (ABQOL) and the Treatment Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaires

Cited by 25 publications

References 21 publications

The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

<p>Depression and Anxiety in Patients with Bullous Pemphigoid: Impact and Management Challenges</p>

Actigraphy‐measured nocturnal wrist movements and assessment of sleep quality in patients with bullous pemphigoid: a pilot case–control study

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