Measuring of gastric emptying in Egyptian pediatric patients with portal hypertension by using real-time ultrasound

Fahmy, Mona; Osman, Mahmoud A.; Mahmoud, Rasha Hamed; Mohamed, Lamiaa K; Seif-elnasr, Khaled I; Eskander, Ayman

doi:10.4103/1319-3767.91739

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Although parameters of malnutrition may correlate with delayed gastric emptying, a clear correlation has not been reported in malnourished patients with Crohn's disease . One study found statistically significant delayed gastric emptying in patients with portal hypertension compared to healthy controls, postulating that delayed gastric emptying can lead to or aggravate portal hypertensive gastropathy . Patients with diabetes mellitus type I, Turner's syndrome, pancreatic insufficiency, and cystic fibrosis have a higher prevalence of gastroparesis than the standard population .…”

Section: Resultsmentioning

confidence: 99%

“…Data on other gastric motor function tests used in adults are still limited in children. Several studies report utility of ultrasound as a non‐invasive measure of proximal and distal compartment sizes and antral contractility in response to a meal . In one study, distention of antrum rather than gastric emptying time as measured by ultrasound correlated with worse dyspeptic scores in a subgroup with delayed gastric emptying .…”

Section: Resultsmentioning

confidence: 99%

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Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Kovacic

Elfar

Rosen

et al. 2019

Neurogastroenterology Motil

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Background Due to scarcity of scientific literature on pediatric gastroparesis, there is a need to summarize current evidence and identify areas requiring further research. The aim of this study was to provide an evidence‐based review of the available literature on the prevalence, pathogenesis, clinical presentation, diagnosis, treatment, and outcomes of pediatric gastroparesis. Methods A search of the literature was performed using the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines with the following databases: PubMed, EMBASE, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, and Web of Science. Two independent reviewers screened abstracts for eligibility. Key Results Our search yielded 1085 original publications, 135 of which met inclusion criteria. Most articles were of retrospective study design. Only 12 randomized controlled trials were identified, all of which were in infants. The prevalence of pediatric gastroparesis is unknown. Gastroparesis may be suspected based on clinical symptoms although these are often non‐specific. The 4‐hour nuclear scintigraphy scan remains gold standard for diagnosis despite lack of pediatric normative comparison data. Therapeutic approaches include dietary modifications, prokinetic drugs, and postpyloric enteral tube feeds. For refractory cases, intrapyloric botulinum toxin and surgical interventions such as gastric electrical stimulation may be warranted. Most interventions still lack rigorous supportive data. Conclusions Diagnosis and treatment of pediatric gastroparesis are challenging due to paucity of published evidence. Larger and more rigorous clinical trials are necessary to improve outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Kovacic

Elfar

Rosen

et al. 2019

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

“…All parts of the gastrointestinal tract can be affected. Numerous studies have reported delayed gastric emptying in patients with cirrhosis and portal hypertension compared to healthy controls [ 101 , 102 , 103 ]. Intestinal motility can be affected, with altered timing, frequency and amplitude of contractions described [ 104 , 105 , 106 ], with cirrhotic patients with portal hypertension being more frequently affected than those without portal hypertension [ 105 ].…”

Section: Complications Of Portal Hypertension and Their Role In Malnu...mentioning

confidence: 99%

Portal Hypertension in Malnutrition and Sarcopenia in Decompensated Cirrhosis—Pathogenesis, Implications and Therapeutic Opportunities

Terbah,

Testro,

Gow

et al. 2023

Nutrients

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Malnutrition and sarcopenia are highly prevalent in patients with decompensated cirrhosis and are associated with poorer clinical outcomes. Their pathophysiology is complex and multifactorial, with protein-calorie malnutrition, systemic inflammation, reduced glycogen stores and hormonal imbalances all well reported. The direct contribution of portal hypertension to these driving factors is however not widely documented in the literature. This review details the specific mechanisms by which portal hypertension directly contributes to the development of malnutrition and sarcopenia in cirrhosis. We summarise the existing literature describing treatment strategies that specifically aim to reduce portal pressures and their impact on nutritional and muscle outcomes, which is particularly relevant to those with end-stage disease awaiting liver transplantation.

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Potential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy

Matsui¹,

Nakagawa²,

Okumura³

et al. 2021

European Journal of Pharmaceutical Sciences

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Measuring of gastric emptying in Egyptian pediatric patients with portal hypertension by using real-time ultrasound

Cited by 5 publications

References 18 publications

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

Portal Hypertension in Malnutrition and Sarcopenia in Decompensated Cirrhosis—Pathogenesis, Implications and Therapeutic Opportunities

Potential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy

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