Abstract:The present work aimed to test the relationship between depression severity and several dimensions of functioning as assessed by the SF-36 at the population level. A sample of 551 participants from the second phase of the ODIN study (228 controls without depression, and 313 persons endorsing ICD criteria for major depression) were selected for a further assessment of several variables, including quality of life (QoL) related to physical and mental health as measured with the SF-36. Statistically significant differences between controls and the major depression group were found in both physical and mental markers of health, regardless of the level of depression severity; however, there were very few differences in QoL between levels of depression as defined by ICD-10. Likewise, there were no differences according to the type of depression (single episode vs. recurrent). These results suggest doubts about the adequacy of the current ICD classification of depression into three levels of severity.