Measuring Health in Rheumatic Disorders by Means of a Swedish Version of the Sickness Impact Profile: Results from a Population Study

Sullivan, Marianne; Ahlmén, Monica; Archenholtz, Birgitha; Svensson, Gunilla Limbäck

doi:10.3109/03009748609102088

Cited by 122 publications

(53 citation statements)

References 15 publications

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“…For each dimension, the percentage of maximum dysfunction is calculated according to predetermined weights, ranging from 0 to 100 (most dysfunction). Based on experiences in Sweden (Sullivan et al, 1986), limits for no (score = 0), slight to moderate (scores 1-10) and marked dysfunction (scores 11-100) were defined (Augustinsson et al, 1989). We used a dichotomization with the cut-off score of ≥11.…”

Section: Indicator and Standard Measuresmentioning

confidence: 99%

Clinical relevance of single item quality of life indicators in cancer clinical trials

Bernhard

Sullivan

Hürny³

et al. 2001

Br J Cancer

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SummaryWe investigated the hypothesis that global single-item quality-of-life indicators are less precise for specific treatment effects (discriminant validity) than multi-item scales but similarly efficient for overall treatment comparisons and changes over time (responsiveness) because they reflect the summation of the individual meaning and importance of various factors. Linear analogue self-assessment (LASA) indicators for physical well-being, mood and coping were compared with the Hospital Anxiety and Depression Scale (HAD), the Mood Adjective Check List (MACL) and the emotional behaviour and social interaction scales of the Sickness Impact Profile (SIP) in 84 patients with early breast cancer receiving adjuvant therapy. Discriminant validity was investigated by multitrait-multimethod correlation, responsiveness by standardized response mean (SRM). Discriminant validity of the indicators was present at baseline but less under treatment. Responsiveness was demonstrated by the expected pattern among treatments (P = 0.008). In patients without chemotherapy, the SRMs indicated moderate (0.5-0.8) to large (>0.8) improvements in physical well-being (0.70), coping (0.92), HAD anxiety (0.89) and depression (1.19), and MACL mental well-being (0.68). In patients with chemotherapy for the first 3 months, small but clinically significant improvements (>).2) included mood (0.38), coping (0.41), HAD axiety (0.31) and MACL mental well-being (0.35). Patients with 6 months chemotherapy showed no changes. The indicators also reflected mood disorders (HAD) and marked psychosocial dysfunction (SIP) at baseline and under treatment according to pre-defined cut-off levels. Global indicators were confirmed to be efficient for evaluating treatments overall and changes over time. The lower reliability of single as opposed to multi-item scales affects primarily their discriminant validity. This is less decisive in large sample sizes. PATIENTS AND METHODS SampleThis study included a consecutive sample of patients with operable breast cancer from Sahlgrenska University Hospital in Göteborg which were randomized into one of the following IBCSG adjuvant therapy trials: Trial VI, for pre-and peri-menopausal, nodepositive (N+) patients; Trial VII, for postmenopausal N+ patients; Trial VIII, for pre-and peri-menopausal, node-negative (N-) patients; Trial IX, for postmenopausal N-patients. In these trials, varying schedules of chemotherapy, endocrine therapy and their combinations were studied. The chemotherapy consisted of CMF (cyclophosphamide, methotrexate and 5-fluorouricil); the endocrine therapy was Tamoxifen or LH-RH (luteinizing hormone-releasing hormone) analogue. In patients with conservative surgery (quadrantectomy or lumpectomy) radiotherapy was started 2 weeks after the last chemotherapy course, or within 3 months in case of endocrine therapy alone. The randomization in Trials VI and VII was stratified by institution, type of surgery and oestrogen receptor (ER) status. The randomization in Trials VIII and IX was stratified by i...

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Section: Indicator and Standard Measuresmentioning

confidence: 99%

Clinical relevance of single item quality of life indicators in cancer clinical trials

Bernhard

Sullivan

Hürny³

et al. 2001

Br J Cancer

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“…26 Items comprising the SCI QL-23 were derived and adopted from an extensive battery of specific and generic questionnaires applied in a study of persons with SCI. 26 The SCI QL-23 consists of three factors; Physical and social functioning (FUNC; 10 items) was derived from the Swedish version 30 of the Sickness Impact Profile (SIP). 31 FUNC covers functional limitations in mobility, body care, and movement and social interaction.…”

Section: Measuring Instrumentsmentioning

confidence: 99%

Health and quality of life of persons with spinal cord lesion in Australia and Sweden

et al. 2004

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Study design: Cross-sectional questionnaire study. Objectives: The aim of the study was to demonstrate the value of common general healthrelated quality of life (HRQL) instruments, readily available for cross-cultural comparisons, in persons with spinal cord lesion (SCL) treated at spinal units in Melbourne, Australia and in Gothenburg, Sweden. Another aim was to determine as to which of the independent variables were the most powerful predictors of global QL in the two SCL groups. Settings: Australia and Sweden. Methods: Two groups consisting of 89 Australian and 71 Swedish SCL persons were surveyed. The two groups were matched according to sex, age, time since injury and level of injury. The 36-item short-form health survey (SF-36) and the Spinal Cord Injuries Quality of Life-23-item questionnaire were used to cover essential generic and specific domains of health and quality of life. Clinical and sociodemographic data were collected using questionnaires. For interpretation purpose, available general population data were used. Results: The most important predictors of QL perception in the Australian group were the same as for the Swedish group; mood, physical and social functioning and problems regarding injury. In total, 61% (Australian group) and 52% (Swedish group) of the variance was explained by these variables. Despite similarities of health profiles, some areas of the SF-36 differed between the two groups. Conclusion: The demonstrated HRQL profiles in SCL persons have shown that valid measures can provide new information of clinical value beyond the self-evident physical and practical restrictions due to injury. Illustrative comparisons, such as those presented here between Australia and Sweden, may extend our knowledge about areas where the SCL persons themselves are the logical experts, for example, maintenance of personal roles, social interaction and emotional well-being.

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“…Sickness Impact Profile. Functional status was measured by an extensively validated Swedish version [22] of the SIP [8]. This is a well-known generic health status questionnaire, constructed to facilitate comparisons between different health conditions over a range of important functional aspects.…”

Section: Physiological Measurementsmentioning

confidence: 99%

Health-related quality of life in COPD: why both disease-specific and generic measures should be used

Engström

Persson²,

Larsson³

et al. 2001

Eur Respir J

169

139

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Health-related quality of life in COPD: why both disease-specific and generic measures should be used. C.P. Engström, L.O. Persson, S. Larsson, M. Sullivan. #ERS Journals Ltd 2001. ABSTRACT: Although research has consistently demonstrated that chronic obstructive pulmonary disease (COPD) impairs health-related quality of life (HRQL), little agreement has been evidenced regarding the factors identified as contributing to impaired HRQL. The aim was to study such factors using well established generic and specific HRQL instruments.The patients (n~68) were stratified by forced expiratory volume in one second (FEV1) to represent a wide range of disease severity. Pulmonary function, blood gases and 6-min walking distance test (6MWD) were assessed. HRQL instruments included: St George9s Respiratory Questionnaire (SGRQ), Sickness Impact Profile (SIP), Hospital Anxiety and Depression Scale and Mood Adjective Check List.The strength of the impact of COPD on HRQL was represented along a continuum ranging from lung function, functional status (physical and psychosocial) to wellbeing. Although correlations between FEV1 versus SGRQ total and SIP overall scores (r~-0.42 and -0.32) were stronger than previously reported, multiple regression analyses showed that lung function contributed little to the variance when dyspnoearelated limitation, depression scores and 6MWD were included in the models. These three factors were important to varying degrees along the whole range of HRQL.Physiological, functional and psychosocial consequences of chronic obstructive pulmonary disease are only poorly to moderately related to each other. The present study concludes that a comprehensive assessment of the effects of chronic obstructive pulmonary disease requires a battery of instruments that not only tap the diseasespecific effects, but also the overall burden of the disease on everyday functioning and emotional wellbeing.

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Measuring Health in Rheumatic Disorders by Means of a Swedish Version of the Sickness Impact Profile: Results from a Population Study

Cited by 122 publications

References 15 publications

Clinical relevance of single item quality of life indicators in cancer clinical trials

Clinical relevance of single item quality of life indicators in cancer clinical trials

Health and quality of life of persons with spinal cord lesion in Australia and Sweden

Health-related quality of life in COPD: why both disease-specific and generic measures should be used

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