Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis

Klappacher, G; Franzen, P.; Haab, Doris; Mehrabi, Mohammad Reza; Binder, Michael; Plesch, Karina; Pacher, Richard; Grimm, Michael; Pribill, Ingrid; Eichler, Hans‐Georg; Glogar, Helmut D.

doi:10.1016/s0002-9149(99)80686-9

Cited by 232 publications

(173 citation statements)

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“…Elevated circulating levels of type III collagen is associated with increased aortic fibrosis and stiffness,39 increased myocardial collagen types I and III,33 systolic and diastolic dysfunction of right and left ventricles in hypertensive patients,35, 40 and diastolic dysfunction in HFpEF patients39, 41, 42 and is partly associated with adverse prognosis in HFpEF patients 34. On the other hand, it has been recently reported that type IV collagen 7S, which is a relatively specific fibrosis marker in the liver, is correlated with pulmonary capillary wedge pressure and right ventricular and atrial pressure, but not with cardiac index,37 and associated with higher 1 year incidence of death or HF hospitalization in patients with HF 37.…”

Section: Discussionmentioning

confidence: 99%

Liver fibrosis score predicts mortality in heart failure patients with preserved ejection fraction

et al. 2017

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AimsHeart failure with preserved ejection fraction (HFpEF) has several pathophysiological aspects, including stiffness and/or congestion of multiple organs. Poor prognosis is expected in heart failure patients with liver stiffness, which has recently been assessed by non‐alcoholic fatty liver disease fibrosis score (NFS; based on aspartate aminotransferase to alanine aminotransferase ratio, platelet counts, and albumin). We aimed to investigate the impact of NFS on prognosis of HFpEF patients, with consideration for the peripheral collagen markers such as procollagen type III peptide (PIIIP), type IV collagen 7S, and hyaluronic acid.Methods and resultsWe performed a prospective observational study. Consecutive 492 hospitalized HFpEF patients were divided into four groups based on their NFS: first–fourth quartiles (n = 123). The fourth quartile group had the highest levels of PIIIP, type IV collagen 7S, hyaluronic acid, and B‐type natriuretic peptide (P<0.001 each). In addition, there were significant positive correlations between PIIIP, type IV collagen 7S, hyaluronic acid, B‐type natriuretic peptide, and NFS (P < 0.001 each). In the follow‐up period (mean 1107 days), 93 deaths occurred. All‐cause mortality increased in all four quartiles (8.1%, 12.2%, 23.6%, and 31.7%, P < 0.001). In the multivariable Cox proportional hazard analysis, NFS was an independent predictor of all‐cause mortality in the HFpEF patients.ConclusionsNFS, a novel indicator of liver fibrosis, correlates with circulating systemic markers of fibrosis and congestion and is associated with higher all‐cause mortality in HFpEF patients. NFS can be calculated simply and may be a useful tool to assess liver stiffness and prognosis in HFpEF patients.

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Section: Discussionmentioning

confidence: 99%

Liver fibrosis score predicts mortality in heart failure patients with preserved ejection fraction

et al. 2017

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“…5,7,[25][26][27] Prior studies have documented elevated PIIINP levels in patients with a variety of abnormalities influencing cardiac structure or function. 7,8 In an adequately 'powered' study of a community-based sample, we found that plasma PIIINP levels were correlated with age and BMI, but not with LV structure or function after adjustment for conventional risk factors. These findings suggest limited utility for measurement of plasma PIIINP levels to detect subclinical cardiac disease in the ambulatory setting.…”

Section: Discussion Principal Findingsmentioning

confidence: 99%

“…The N-terminal and Cterminal peptides are cleaved by endopeptidases after pro-collagen has been secreted from the cell. Elevated levels of pro-collagen type III N-terminal peptide (PIIINP) have been observed in individuals with hypertension, 5,6 dilated cardiomyopathy, 7 hypertrophic cardiomyopathy, 8 and recent myocardial infarction, 9,10 suggesting that the circulating peptide may be a useful marker of active myocardial collagen synthesis. In a retrospective analysis from the Randomized Aldactone Evaluation Study, high baseline levels of circulating PIIINP were predictive of death and hospitalization in heart failure patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community

Wang

Larson

Benjamin

et al. 2007

American Heart Journal

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Background-Left ventricular remodeling is characterized by increased collagen deposition in the extracellular matrix. Levels of plasma pro-collagen type III amino-terminal peptide (PIIINP), a marker of collagen turnover, are elevated in the setting of recent myocardial infarction, heart failure, and cardiomyopathy. Whether plasma PIIINP levels are a useful indicator of subclinical left ventricular abnormalities in ambulatory individuals has not been studied.

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“…16 In patients with severe congestive heart failure, serum PIIINP concentration is closely correlated with clinical stage and outcome. 17 Serum and urinary PIIINP concentrations have been studied in humans with various renal diseases 18,19 as well as in patients after renal transplantation 20 and have been shown to correlate with the extent of organ fibrosis.…”

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confidence: 99%

Analytical, physiologic, and clinical validation of a radioimmunoassay for measurement of procollagen type III amino terminal propeptide in serum and bronchoalveolar lavage fluid obtained from dogs

Schüller¹,

Valentin²,

Rémy³

et al. 2006

ajvr

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Objective—To validate a radioimmunoassay for measurement of procollagen type III amino terminal propeptide (PIIINP) concentrations in canine serum and bronchoalveolar lavage fluid (BALF) and investigate the effects of physiologic and pathologic conditions on PIIINP concentrations. Sample Population—Sera from healthy adult (n = 70) and growing dogs (20) and dogs with chronic renal failure (CRF; 10), cardiomyopathy (CMP; 12), or degenerative valve disease (DVD; 26); and sera and BALF from dogs with chronic bronchopneumopathy (CBP; 15) and healthy control dogs (10 growing and 9 adult dogs). Procedure—A radioimmunoassay was validated, and a reference range for serum PIIINP (S-PIIINP) concentration was established. Effects of growth, age, sex, weight, CRF, and heart failure on S-PIIINP concentration were analyzed. In CBP-affected dogs, S-PIIINP and BALF-PIIINP concentrations were evaluated. Results—The radioimmunoassay had good sensitivity, linearity, precision, and reproducibility and reasonable accuracy for measurement of S-PIIINP and BALF-PIIINP concentrations. The S-PIIINP concentration reference range in adult dogs was 8.86 to 11.48 μg/L. Serum PIIINP concentration correlated with weight and age. Growing dogs had significantly higher S-PIIINP concentrations than adults, but concentrations in CRF-, CMP-, DVD-, or CBP-affected dogs were not significantly different from control values. Mean BALF-PIIINP concentration was significantly higher in CBP-affected dogs than in healthy adults. Conclusions and Clinical Relevance—In dogs, renal or cardiac disease or CBP did not significantly affect S-PIIINP concentration; dogs with CBP had high BALF-PIIINP concentrations. Data suggest that the use of PIIINP as a marker of pathologic fibrosis might be limited in growing dogs.

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Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis

Cited by 232 publications

References 21 publications

Liver fibrosis score predicts mortality in heart failure patients with preserved ejection fraction

Liver fibrosis score predicts mortality in heart failure patients with preserved ejection fraction

Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community

Analytical, physiologic, and clinical validation of a radioimmunoassay for measurement of procollagen type III amino terminal propeptide in serum and bronchoalveolar lavage fluid obtained from dogs

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