Measuring expectation of pain: Contingent negative variation in placebo and nocebo effects

Piedimonte, Alessandro; Guerra, Giorgia; Vighetti, Sergio; Carlino, Elisa

doi:10.1002/ejp.990

Cited by 33 publications

(59 citation statements)

References 53 publications

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“…Lower values of VAS on the placebo group were expected, as this effect is derived from the participants' perception and experience of receiving a pain‐reducing treatment as well as the integration of this sensory information with memories of previous experiences and current expectations . Placebo effects are also associated with the expected pain levels and emotional feelings, such as reduced anxiety and the previous experience of relief . The current study used a simulated low intensity laser therapy with the equipment emitting beep sounds, but without the actual laser application.…”

Section: Discussionmentioning

confidence: 91%

“…30,31 Placebo effects are also associated with the expected pain levels and emotional feelings, such as reduced anxiety and the previous experience of relief. 31,32 The current study used a simulated low intensity laser therapy with the equipment emitting beep sounds, but without the actual laser application. The equipment is widely used by physical therapists to treat pain and inflammatory musculoskeletal conditions.…”

Section: Discussionmentioning

confidence: 99%

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Effects of 8 weeks of masticatory muscles focused endurance exercises on women with oro‐facial pain and temporomandibular disorders: A placebo randomised controlled trial

Barbosa

Tahara

Ferreira

et al. 2019

J of Oral Rehabilitation

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Background Exercises are used to treat temporomandibular disorders (TMD), but they are often assessed with other therapies. Local endurance exercises may alter the resistance to fatigue and pain. Objective To assess the effects of an 8‐week protocol of local endurance exercises of masticatory muscles on muscle excitation, force response, perceived pain and over muscle efficiency. Design Randomised controlled trial. Setting Ambulatory care. Subjects In a placebo randomised controlled trial, 46 women with TMD and oro‐facial pain were randomised into intervention group and placebo group. The intervention group received a protocol of biting endurance exercises, controlled by biofeedback. The placebo group received a placebo (simulated laser therapy). Main Outcome Measures The primary outcomes were collected at baseline, 4 weeks and 8 weeks. Pain was assessed through visual analogue scale (VAS) and pressure pain thresholds (PPT). Bite force was collected by a load cell synchronised with surface electromyography of masticatory muscles, bilaterally. Results Pain scores decreased for both groups, but the intervention group showed lower values at 8 weeks. No differences were noted between groups for PPT, but the results increased for both overtime. Time until fatigue and muscle efficiency were higher in the intervention group vs placebo group in both within‐ and between‐subject analysis. Force increased from 4 to 8 weeks in the PG, without differences between groups. Temporal muscle excitation was higher on 8 weeks compared with baseline for the intervention group, without differences between groups. Conclusion Eight‐week exercise protocol of muscle endurance alleviates the pain and improves the resistance to fatigue and muscle efficiency in TMD subjects.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of 8 weeks of masticatory muscles focused endurance exercises on women with oro‐facial pain and temporomandibular disorders: A placebo randomised controlled trial

Barbosa

Tahara

Ferreira

et al. 2019

J of Oral Rehabilitation

View full text Add to dashboard Cite

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“…In contrast, in the present study we did not simply investigate pain anticipation and motor preparation but the effects of pain on the preparation of a biologically meaningful motor response. Another study investigated EEG activity during the anticipation of painful stimuli that could be stopped by a motor response (Piedimonte et al 2017). The results showed that EEG responses related to movement preparation did not consistently differ between different expectations of pain.…”

Section: Pain and Motor Processes In The Human Brainmentioning

confidence: 99%

“…Vice versa, pain critically influences motor behavior (Bank et al 2013;Hodges and Tucker 2011), which likely contributes to the pathology of chronic pain (Hodges and Smeets 2015). Consequently, the relationship between pain and motor processes increasingly attracts attention (Morrison et al 2013;Piedimonte et al, 2017;Sullivan 2008;Tabor et al 2017;Vogt and Sikes 2009;Wiech and Tracey 2013).…”

mentioning

confidence: 99%

Influence of pain on motor preparation in the human brain

Postorino

Nickel

et al. 2017

Journal of Neurophysiology

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The protective function of pain depends on appropriate motor responses to avoid injury and promote recovery. The preparation and execution of motor responses is thus an essential part of pain. However, it is not yet fully understood how pain and motor processes interact in the brain. Here we used electroencephalography to investigate the effects of pain on motor preparation in the human brain. Twenty healthy human participants performed a motor task in which they performed button presses to stop increasingly painful thermal stimuli when they became intolerable. In another condition, participants performed button presses without concurrent stimulation. The results show that the amplitudes of preparatory event-related desynchronizations at alpha and beta frequencies did not differ between conditions. In contrast, the amplitude of the preparatory readiness potential was reduced when a button press was performed to stop a painful stimulus compared with a button press without concomitant pain. A control experiment with nonpainful thermal stimuli showed a similar reduction of the readiness potential when a button press was performed to stop a nonpainful thermal stimulus. Together, these findings indicate that painful and nonpainful thermal stimuli can similarly influence motor preparation in the human brain. Pain-specific effects on motor preparation in the human brain remain to be demonstrated. Pain is inherently linked to motor processes, but the interactions between pain and motor processes in the human brain are not yet fully understood. Using electroencephalography, we show that pain reduces movement-preparatory brain activity. Further results indicate that this effect is not pain specific but independent of the modality of stimulation.

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“…Consequently, many researchers have begun to use brain-imaging technology to study the brain's responses to placebo analgesia and nocebo hyperalgesia [ 17 ]. Some researchers have suggested that the placebo effect could activate the anterior cingulate cortex (ACC), amygdala (AMYG), prefrontal cortex (PFC), insula (IC), and thalamus (THS) and that the activation of these areas is closely related to the placebo-mediated analgesic effect [ 18 – 20 ]. Furthermore, Schmid et al [ 21 ] suggested that the brain areas of the THS, IC, AMYG, and midcingulate cortex (MCC) are closely related to the effect of nocebo hyperalgesia.…”

Section: Introductionmentioning

confidence: 99%

Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI

et al. 2020

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It is generally believed that the placebo response can elicit an analgesic effect, whilst the nocebo response can elicit a hyperalgesia effect in pain. Placebo analgesia and nocebo hyperalgesia effects are increasing concerns for researchers. Growing evidence suggests personality differences have an impact on both placebo and nocebo effects. However, previous studies have not reached a unified conclusion. We designed this study to explore the personality differences of functional magnetic resonance imaging (fMRI) signals in placebo response and nocebo response by using psychophysiological interaction (PPI) analysis. 30 healthy subjects underwent conditioning induction training to establish expectations of placebo effect and nocebo effect, and then, all subjects completed the following experimental procedures: (1) baseline scanning, (2) acute pain model establishment, (3) pain status scanning, and (4) pseudorandom scanning of block design of placebo response or nocebo response. Behavioral data were collected after each scan. The results of this study showed that (1) there were significant differences of VAS placebo intervention between the extrovert group and the introvert group ( p = 0.004 ); (2) there were significant differences of VAS nocebo intervention between the extrovert group and the introvert group ( p = 0.011 ); (3) there were significant differences between the VAS placebo intervention and VAS pain status (baseline) in both the extrovert group ( p < 0.001 ) and the introvert group ( p = 0.001 ); (4) there were significant differences between the VAS nocebo intervention and VAS pain status (baseline) in both the extrovert group ( p = 0.008 ) and the introvert group ( p < 0.001 ). Moreover, there were significant differences in the brain network for placebo and nocebo responses between different personalities. We found that (1) deactivation differences of the pain-related network and limbic system play an important role in personality differences associated with placebo analgesia and (2) differences of control of anxiety and activation of dorsolateral prefrontal cortex may cause the personality differences observed in nocebo hyperalgesia.

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Measuring expectation of pain: Contingent negative variation in placebo and nocebo effects

Abstract: Dissection of placebo hypoalgesia, differentiating the sensory component (pain perception) from the motor component (pain avoidance). Study of these components using the contingent negative variation (CNV) as an electrophysiological objective measure.

Cited by 33 publications

References 53 publications

Effects of 8 weeks of masticatory muscles focused endurance exercises on women with oro‐facial pain and temporomandibular disorders: A placebo randomised controlled trial

Effects of 8 weeks of masticatory muscles focused endurance exercises on women with oro‐facial pain and temporomandibular disorders: A placebo randomised controlled trial

Influence of pain on motor preparation in the human brain

Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI

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