Measuring drug similarity using drug–drug interactions
Ji Lv,
Guixia Liu,
Yuan Ju
et al.
Abstract:Combination therapy is a promising approach to address the challenge of antimicrobial resistance, and computational models have been proposed for predicting drug–drug interactions. Most existing models rely on drug similarity measures based on characteristics such as chemical structure and the mechanism of action. In this study, we focus on the network structure itself and propose a drug similarity measure based on drug–drug interaction networks. We explore the potential applications of this measure by combini… Show more
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