Measuring control of disease in Chronic Rhinosinusitis; assessing the correlation between SinoNasal Outcome Test-22 and Visual Analogue Scale item scores

Abstract

Background: In chronic rhinosinusitis (CRS), aim of treatment is control of disease. EPOS2020 suggests the use of visual analogue scale (VAS) measurements on several symptoms. We aim to determine if individual VAS items can be replaced by widely used SinoNasal Outcome Test-22 (SNOT-22) items when determining control of disease, to avoid using double measurements and to stimulate its use in clinical practice. Methods: Analyses were made on correlations between individual SNOT-22 scores and symptom-specific questions from consecutive patients with CRS visiting our tertiary referral rhinologic clinic for the first time. Results: 157 CRS patients were included. Correlations of individual items were strong (r greater than 0.8). Best parity in sensitivity, specificity, positive predicting value, negative predicting value, odds ratio and Receiver Operating Characteristic curves were found in individual item score of VAS greater than 5 and SNOT item-score ≥3. This cut off is valid for measuring control of disease, combining several nasal, facial pain and sleep symptoms (controlled, partially controlled and uncontrolled). Conclusion: There is strong correlation between individual items measured as SNOT or VAS. For the definition of CRS disease control, as proposed in EPOS2020, the use of symptoms specific SNOT ≥3 is predictive of VAS greater than 5.

Two‐year results of tapered dupilumab for CRSwNP demonstrates enduring efficacy established in the first 6 months

“…Assessment of biological response and current CRS control was respectively performed per EUFOREA2023 and EPOS2020 11,27 . As cutoff points for the assessed criteria, related SNOT‐22 item scores of >3 and ≤3 were used respectively for the in EPOS2020 suggested cutoff points VAS >5 and ≤5, which are virtually interchangeable 51 …”

“…11,27 As cutoff points for the assessed criteria, related SNOT-22 item scores of >3 and ≤3 were used respectively for the in EPOS2020 suggested cutoff points VAS >5 and ≤5, which are virtually interchangeable. 51…”

Comparison of Long-Term Postoperative Outcomes of the Subtypes of Chronic Rhinosinusitis with Nasal Polyps

“…It can be largely divided into four domains: rhinologic (nasal obstruction, runny nose, cough, sneezing, loss of smell, posterior nasal drip), sleep disorder (difficulty in falling asleep, frequent wake up, lack of deep sleep waking up tired) psychological dysfunction (lack of concentration, anxiety, irritable, embarrassed, sad), and ear/facial symptoms (earfullness, ear pain, dizziness, facial tenderness or pain) [ 21 ]. The total score and the score of each domain reflect the overall disease burden and HRQOL status in patients with CRSwNP [ 18 , 19 , 20 , 21 , 22 , 23 ]. In this study, the HRQOL status was determined preoperatively and at the last follow-up date postoperatively using SNOT-22.…”

Outcome measures for chronic rhinosinusitis with nasal polyps

“…The exact definition of CRS control -its criteria and how to measure those criteria -remains a topic of investigation (90,341,342) . Recent studies have shown that patients' and healthcare providers' views of CRS control largely align (343) and that patients' assessments of their own CRS control reflects their CRS disease burden (344) .…”