Measuring clusters of spontaneous spike-wave discharges in absence epileptic rats

Midzyanovskaya, I.S.; Strelkov, V. V.; Rijn, Clementina van; Budziszewska, Bogusława; Luijtelaar, Egidius van; Kuznetsova, G. M.

doi:10.1016/j.jneumeth.2005.12.014

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…The observed decaying hazard rates of the durations of the inter-SWD intervals in the saline group suggest that, whenever an SWD occurs, it might be easier for a subsequent SWD to occur. This would suggest that SWDs are likely to cluster, which is supported by the data of Midzyanovskaya et al (2006). After vigabatrin, the overall probability that an SWD will start is increased, as was shown by the overall higher value of the hazard rates of the duration of the inter-SWD intervals.…”

Section: Discussionsupporting

confidence: 58%

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GABAergic mechanisms in absence epilepsy: a computational model of absence epilepsy simulating spike and wave discharges after vigabatrin in WAG/Rij rats

Bouwman¹,

Suffczyński²,

Silva³

et al. 2007

Eur J of Neuroscience

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In this study, the effects of vigabatrin on spike-and-wave discharges (SWDs) were measured in WAG/Rij rats, an animal model of absence epilepsy. Vigabatrin was used with the aim of enhancing GABAergic neurotransmission, and in this way to investigate the role of this process in the properties of SWDs. The study was carried out both in the rat, in vivo, and also using a computational model, in order to test different mechanisms that may account for the changes in SWDs after vigabatrin. The model parameters, representing GABA levels, were changed according to the known, and assumed, mechanism of action of the drug. The results show that the computational model can most adequately simulate the data obtained in vivo on the assumption that the enhancement of GABAergic neurotransmission due to application of vigabatrin is most pronounced at the level of the thalamic relay nuclei (TC cells). Furthermore, vigabatrin was shown to affect both the SWD starting and stopping mechanisms, as reflected by hazard rates. Based on these results, we suggest that GABAergic neurotransmission in TC cells is actively involved in the SWD termination.

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Section: Discussionsupporting

confidence: 58%

“…The observed decaying hazard rates of the durations of the inter‐SWD intervals in the saline group suggest that, whenever an SWD occurs, it might be easier for a subsequent SWD to occur. This would suggest that SWDs are likely to cluster, which is supported by the data of Midzyanovskaya et al . (2006).…”

Section: Discussionmentioning

confidence: 99%

GABAergic mechanisms in absence epilepsy: a computational model of absence epilepsy simulating spike and wave discharges after vigabatrin in WAG/Rij rats

Bouwman¹,

Suffczyński²,

Silva³

et al. 2007

Eur J of Neuroscience

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“…Each distribution deviated significantly from the expected beta distribution (p<0.0001, Anderson-Darling goodness of fit test). Clustering of SWDs is yet a further characteristic feature of absence seizures (Midzyanovskaya et al 2006). …”

Section: Resultsmentioning

confidence: 99%

Hidden in plain sight: spike‐wave discharges in mouse inbred strains

Letts

Beyer

Frankel

2014

Genes Brain and Behavior

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27 inbred strains of mice were tested for spike-wave discharge activity by video-electroencephalographic recordings over a 24-hour recording period. 8 strains had reproducible, frequent spike-wave discharges, including 5 strains (C57BLKS/J, CBA/J, DBA/1J, NOR/LtJ, SM/J) previously undiagnosed for this distinctive phenotype. 18 other strains exhibited no such activity. Spike-wave discharges usually occurred while the subject was motionless, and in a significant number of annotated instances coincided with an arrest of the subject’s relatively unrestrained locomotor activity, which resumed immediately after the discharge ended. In all 5 new strains, spike-wave discharges were suppressed by ethosuximide administration. From the genealogy of inbred strains, we suggest that two ancestors, A and DBA, transmitted genotypes required for spike-wave discharge in all positive strains. Together these strains with spike-wave discharges provide new opportunities to understand the genetic core susceptibility of this distinctive electroencephalographic activity and to explore its relationship to absence epilepsy, a human disorder for which few genes are known.

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“…A number of factors influencing the probability of seizure occurrence in this strain have already been explored, such as the age of the rats [17,18], the circadian timing system [19,20], and sex hormones [21]. Mathematical approaches were also used to describe the timing of seizures' occurrence such as time series analysis of a binary SWDs' signal constructed from long-term EEG recordings [22], the hazard rate, the conditional probability that a seizure starts in the time interval [t,t Δ], given that no seizure has started in the time interval [0, t] [23], and whether principles of intermittency (irregular alternation of phases of apparently periodic and chaotic dynamics) can be demonstrated [24,25]. Other approaches that were used to predict the SWDs' occurrence were based on time-frequency analyses of cortical and thalamic preictal EEG [26], multichannel network analysis of preictal EEG correlates [27][28][29][30], and multichannel synchronization analysis [15].…”

Section: Introductionmentioning

confidence: 99%

Can absence seizures be predicted by vigilance states?: Advanced analysis of sleep–wake states and spike–wave discharges' occurrence in rats

Smyk

Sysoev

Sysoeva

et al. 2019

Epilepsy & Behavior

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Measuring clusters of spontaneous spike-wave discharges in absence epileptic rats

Cited by 10 publications

References 19 publications

GABAergic mechanisms in absence epilepsy: a computational model of absence epilepsy simulating spike and wave discharges after vigabatrin in WAG/Rij rats

GABAergic mechanisms in absence epilepsy: a computational model of absence epilepsy simulating spike and wave discharges after vigabatrin in WAG/Rij rats

Hidden in plain sight: spike‐wave discharges in mouse inbred strains

Can absence seizures be predicted by vigilance states?: Advanced analysis of sleep–wake states and spike–wave discharges' occurrence in rats

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