Measuring chemotherapy‐induced nausea and emesis

Martin, Charles G.; Rubenstein, Edward; Elting, Linda S.; Kim, Young Jun; Osoba, David

doi:10.1002/cncr.11540

Cited by 44 publications

(22 citation statements)

References 28 publications

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“…The measurement of quality of life gives an overall assessment of the impact on the antiemetic on the wellbeing of the patient. This is particularly important not only because it serves to balance the efficacy and toxicity of the antiemetic but also because emesis impacts on other aspects of quality of life such as fatigue, appetite and sleep disturbance [26].…”

Section: Design Issues In Clinical Trialsmentioning

confidence: 99%

Antiemetic research: future directions

Olver

Molassiotis

Aapro

et al. 2010

Support Care Cancer

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Purpose and methods As a part of reviewing the Multinational Association of Supportive Care in Cancer (MASCC) antiemetic guidelines in Perugia in 2009, an expert group identified directions for future antiemetic research. Results and conclusions In future trials, the prediction of nausea and vomiting may combine algorithms based on observed prognostic factors relating to the patient and the anticancer therapy, the identification of the genes that code for receptors, and pharmacogenetic studies of the metabolism of drugs. Design issues for future trials include standardising the emetic stimulus across studies and finding the minimum tolerated effective dose and schedule of an antiemetic. Also control of delayed emesis is not independent of the control of acute emesis. The full range of side effects and the impact on global quality of life scores should be part of the routine assessment of an antiemetic. With current high rates of control of acute vomiting, future trials will need to consider new primary endpoints such as nausea, a complex symptom, where improvement is needed. Economic endpoints should be incorporated to ascertain the cost benefit of antiemetic prophylaxis, taking into account the impact of nausea on work capacity. New antiemetic drugs may be targeted at different receptors, such as opioid, cannabinoid and peptide YY receptors. New research is needed into determining the extent of corticosteroid use. The emetic potential of a range of newer cytotoxics particularly when used in combinations and different scheduling, such as prolonged oral dosing of cytotoxics and use of targeted therapies, are all areas in need of research. More antiemetic studies are needed in niche areas such as in patients receiving high dose chemotherapy, radiation therapy or combined modality therapy. Further evidence of the efficacy of newer antiemetic agents is required in children.

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Section: Design Issues In Clinical Trialsmentioning

confidence: 99%

Antiemetic research: future directions

Olver

Molassiotis

Aapro

et al. 2010

Support Care Cancer

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“…Since healthcare professionals tend to underestimate symptoms compared with patients [17,18], methods based on patient reports are more appropriate to accurately record the symptoms. Many tools based on patient reports have been shown to be effective in recording CINV symptoms, including the Morrow assessment of nausea and emesis (MANE) [24], Rhodes INRV [21], Osoba Nausea and Emesis Module based on the European Organization for Research and Treatment of Cancer (EORTE) QLQ-C30 [25], CINE QOL questionnaire by Martin et al [26], and Functional Living Index-Emesis (FLIE) with a focus on QOL [27]. However, many of these tools are inadequate for clinical use, because daily recording is required, there are too many items to be answered, or there are too few items to be answered that distinguish symptoms in the Which tool is preferable to use in the future?…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the validity of chemotherapy-induced nausea and vomiting assessment in outpatients using the Japanese version of the MASCC antiemesis tool

Matsuda

Okita

Furuhata

et al. 2015

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“…13 The module we used included four questions which asked the extent to which nausea and/or vomiting in the previous 24 hr 1) interfered with appetite, 2) affected sleep, 3) interfered with physical activities (including self care), and 4) interfered with social activities. There were four possible responses to each question, ranging from ''not at all'' to ''very much.''…”

Section: Measurementsmentioning

confidence: 99%