Measuring biomarkers in wastewater as a new source of epidemiological information: Current state and future perspectives

Gracia-Lor, Emma; Castiglioni, Sara; Bade, Richard; Béen, Frederic; Castrignanò, Erika; Covaci, Adrian; González-Mariño, Iria; Hapeshi, Evroula; Kasprzyk-Hordern, Barbara; Kinyua, Juliet; Lai, Foon Yin; Letzel, Thomas; Lopardo, Luigi; Meyer, Markus R.; O’Brien, Jake; Ramin, Pedram; Rousis, Nikolaos I.; Rydevik, Axel; Ryu, Yoshinori; Santos, Miguel M.; Senta, Ivan; Thomaidis, Nikolaos S.; Veloutsou, Sofia; Yang, Zhugen; Zuccato, Ettore; Bijlsma, Lubertus

doi:10.1016/j.envint.2016.12.016

Cited by 234 publications

(166 citation statements)

References 271 publications

(2 reference statements)

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“…For the successful application of WBE, the selection of the most suitable biomarker for analysis is pivotal. There are multiple factors to take into consideration which include stability (eg, in‐sewer and in‐sample), transformation due to microbial activity, and specificity to compound of interest and human metabolism …”

Section: Introductionmentioning

confidence: 99%

A pilot wastewater‐based epidemiology assessment of anabolic steroid use in Queensland, Australia

Shimko

O’Brien

Barron

et al. 2019

Drug Testing and Analysis

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Anabolic‐androgenic steroids are synthetic compounds prohibited due to their performance‐enhancing characteristics. The use of these substances is known to cause health‐related issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available research on the analysis of anabolic steroids is focused on animals and athletes in connection with doping. The potential of wastewater‐based epidemiology as an intelligence tool for the assessment of community level use of anabolic steroids is presented herein. A liquid chromatography tandem mass spectrometry method was developed for the analysis of 10 anabolic‐androgenic steroids and 14 endogenous hormones in influent wastewater. The validated method was applied to sixteen 24‐hour composite wastewater influent samples that were collected over a period of five years from two wastewater treatment plants in Queensland, Australia. Nine investigated compounds were found to be present at concentrations between 14 and 611 ng L−1 which translated into 3–104 mg excreted per 1000 individuals per day. It was concluded that the developed analytical method is suitable for the analysis of AAS in wastewater matrix. Additionally, both the inclusion of metabolites and further investigation into deconjugation by enzymatic hydrolysis would aid in understanding and evaluating community anabolic steroid use. For the first time, this study presents the application of wastewater‐based epidemiology on anabolic‐androgenic steroids in Australia.

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Section: Introductionmentioning

confidence: 99%

A pilot wastewater‐based epidemiology assessment of anabolic steroid use in Queensland, Australia

Shimko

O’Brien

Barron

et al. 2019

Drug Testing and Analysis

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“…Évek óta vizsgálják például az aceszulfám nevű édesí-tőszert, amely teljesen kiürül a szervezetből, és sokáig stabil marad a szennyvízben, így néhány másik anyaggal együtt alkalmasnak tűnik a nagyobb népességszámok visszafejtéséhez való felhasználásra. Ezt nemrég egy ausztrál kutatócsoport vizsgá-latai is megerősítették, amelyek során a 2011-es népszámlálás napján vagy környé-kén gyűjtött mintákat elemezték és vetették egybe a cenzusból nyert adatokkal (Gracia-Lor et al [2017], O'Brien et al [2014]). Egy friss valenciai esettanulmányban (Rico-Andrés-Costa-Picó [2017]) pedig a minták koffein-és kotinintartalmának segítségével próbálták finomítani a népességszámra vonatkozó becslést.…”

Section: A Szennyvízelemzés Módszere éS Bizonytalansági Tényezőiunclassified

Multidiszciplináris eljárás a kábítószerfogyasztás mérésére: a szennyvízelemzésen alapuló drogepidemiológia. Nemzetközi vizsgálatok és adatok

Rózsa¹

2017

Statisztika szemle

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“…Raw wastewater has been recognised as an emerging and useful source to retrieve epidemiological information about substance use and exposure to environmental chemicals at the population level 16 . The approach relies on the fact that wastewater generated by the population of a given catchment contains biomarkers of lifestyle, health and exposure to environmental pollutants.…”

Section: Introductionmentioning

confidence: 99%

Levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in raw wastewater as an innovative perspective for investigating population-wide exposure to third-hand smoke

Lai

Lympousi

Béen

et al. 2018

Sci Rep

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Tobacco smoking is the major cause of many chronic diseases, especially lung cancer. Knowledge about population-wide tobacco use and exposure is essential to characterise its burden on public health and evaluate policy efficacy. Obtaining such knowledge remains challenging with current methods (e.g., surveys, biomonitoring) but can be achievable with wastewater analysis, a promising tool of retrieving epidemiology information. This study examined population-wide exposure to tobacco toxicants and carcinogens through wastewater analysis and explored relationships among these chemicals. Cotinine, trans-3′-hydroxycotinine, anabasine, anatabine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were analysed in samples from Greece, Switzerland and Belgium, where tobacco control policies are different. Measured per-capita mass loads were ranked as: nicotine biomarkers ≫ tobacco markers > carcinogens. Relationships between nicotine biomarkers and tobacco markers implied substantial use of non-tobacco nicotine items besides tobacco products. Geographic profiles of tobacco markers revealed higher levels in Geneva and Athens than Geraardsbergen and Ninove. Environmental third-hand smoke led to NNK detection, with elevated levels observed in Athens where indoor smoking is widespread, posing potential health risks to the population. Our novel outcomes are relevant for public health authorities as they provide indications about external exposure and can thus be used to plan and evaluate tobacco control policies.

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Measuring biomarkers in wastewater as a new source of epidemiological information: Current state and future perspectives

Cited by 234 publications

References 271 publications

A pilot wastewater‐based epidemiology assessment of anabolic steroid use in Queensland, Australia

A pilot wastewater‐based epidemiology assessment of anabolic steroid use in Queensland, Australia

Multidiszciplináris eljárás a kábítószerfogyasztás mérésére: a szennyvízelemzésen alapuló drogepidemiológia. Nemzetközi vizsgálatok és adatok

Levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in raw wastewater as an innovative perspective for investigating population-wide exposure to third-hand smoke

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