Measuring and compensating for ocular longitudinal chromatic aberration

Jiang, Xiaoyun; Kuchenbecker, James A.; Touch, Phanith; Sabesan, Ramkumar

doi:10.1364/optica.6.000981

Cited by 20 publications

(21 citation statements)

References 48 publications

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“…The psychophysical experiments were performed with subjects viewing stimuli generated in a multiwavelength AO vision simulator system equipped with a filter-based Badal LCA compensator, described in detail elsewhere [24] and shown in Fig. 1.…”

Section: B Multiwavelength Adaptive Optics Vision Simulator With a Fmentioning

confidence: 99%

“…The experiments described here entail careful control of chromatic aberration. LCA was compensated with the filter-based Badal compensator whose operation is described in Jiang et al [24]. Briefly, the relative defocus between the red and green wavelengths was altered by translating mirrors M2 and M3 a distance "z" in Fig.…”

Section: B Multiwavelength Adaptive Optics Vision Simulator With a Fmentioning

confidence: 99%

“…To eliminate artifacts produced by the eye's optics, visual stimuli were generated in an AO vision simulator with a filterbased Badal LCA compensator. This instrument corrected for both monochromatic and chromatic aberrations of the eye [24]. The L:M cone ratios of subjects were estimated using flicker photometric ERGs and molecular genetics and were compared against their cone spectral topography obtained with the new method for AO densitometry.…”

Section: Introductionmentioning

confidence: 99%

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Effect of cone spectral topography on chromatic detection sensitivity

et al. 2020

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The spatial and spectral topography of the cone mosaic set the limits for detection and discrimination of chromatic sinewave gratings. Here, we sought to compare the spatial characteristics of mechanisms mediating hue perception against those mediating chromatic detection in individuals with known spectral topography and with optical aberrations removed with adaptive optics. Chromatic detection sensitivity in general exceeded previous measurements and decreased monotonically for increasingly skewed cone spectral compositions. The spatial grain of hue perception was significantly coarser than chromatic detection, consistent with separate neural mechanisms for color vision operating at different spatial scales.

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Section: B Multiwavelength Adaptive Optics Vision Simulator With a Fmentioning

confidence: 99%

Section: B Multiwavelength Adaptive Optics Vision Simulator With a Fmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of cone spectral topography on chromatic detection sensitivity

et al. 2020

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“…Since the LCA of the human retina is quite similar in the population, a single achromatizing lens [19,20] can be designed to compensate LCA for retinal imaging [21][22][23][24]. Techniques for custom adjustment of LCA in an AOSLO can also be used [25]. However, this additional optic adds complexity by requiring the addition of another pupil-conjugate plane and, depending on how it is placed, can give rise to deleterious back-reflections.…”

Section: Introductionmentioning

confidence: 99%

“…However, this additional optic adds complexity by requiring the addition of another pupil-conjugate plane and, depending on how it is placed, can give rise to deleterious back-reflections. The transverse chromatic aberration, or TCA, of the eye has also been studied [25,26] and recently objective techniques to measure it [27,28] and correct it [28][29][30] have been employed. The extent to which the high order aberrations of the eye change with wavelength is less studied [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Wide-vergence, multi-spectral adaptive optics scanning laser ophthalmoscope with diffraction-limited illumination and collection

Mozaffari¹,

Larocca²,

Jaedicke³

et al. 2020

Biomed. Opt. Express

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Visualizing and assessing the function of microscopic retinal structures in the human eye is a challenging task that has been greatly facilitated by ophthalmic adaptive optics (AO). Yet, as AO imaging systems advance in functionality by employing multiple spectral channels and larger vergence ranges, achieving optimal resolution and signal-to-noise ratios (SNR) becomes difficult and is often compromised. While current-generation AO retinal imaging systems have demonstrated excellent, near diffraction-limited imaging performance over wide vergence and spectral ranges, a full theoretical and experimental analysis of an AOSLO that includes both the light delivery and collection optics has not been done, and neither has the effects of extending wavefront correction from one wavelength to imaging performance in different spectral channels. Here, we report a methodology and system design for simultaneously achieving diffraction-limited performance in both the illumination and collection paths for a wide-vergence, multi-spectral AO scanning laser ophthalmoscope (SLO) over a 1.2 diopter vergence range while correcting the wavefront in a separate wavelength. To validate the design, an AOSLO was constructed to have three imaging channels spanning different wavelength ranges (543 ± 11 nm, 680 ± 11 nm, and 840 ± 6 nm, respectively) and one near-infrared wavefront sensing channel (940 ± 5 nm). The AOSLO optics and their alignment were determined via simulations in optical and optomechanical design software and then experimentally verified by measuring the AOSLO's illumination and collection point spread functions (PSF) for each channel using a phase retrieval technique. The collection efficiency was then measured for each channel as a function of confocal pinhole size when imaging a model eye achieving near-theoretical performance. Imaging results from healthy human adult volunteers demonstrate the system's ability to resolve the foveal cone mosaic in all three imaging channels despite a wide spectral separation between the wavefront sensing and imaging channels.

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