Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study

The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

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Section: Main Results In the Last 3 Yearsunclassified

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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Numerical analysis of stenoses severity and aortic wall mechanics in patients with supravalvular aortic stenosis

Lone

Alday

Zakerzadeh

2021

Computers in Biology and Medicine

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Early and long‐term results of surgery for secondary mitral regurgitation with a damaged heart

et al. 2019

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BackgroundSurgery for secondary mitral regurgitation is still controversial, especially when the left ventricle is damaged. The Mitra Clip has been shown to be safe and effective for certain patient groups but does not offer superior control of mitral regurgitation compared with the surgery. If performed safely, the surgery can provide greater benefits over the long‐term. The objective of this study was to retrospectively investigate the early and long‐term results of mitral valve surgery for secondary mitral valve regurgitation with a damaged, dilated left ventricle.MethodsPatients with ejection fraction <40% and left ventricular end‐diastolic/systolic diameter >50/40 mm who underwent mitral valve surgery for secondary mitral regurgitation were investigated retrospectively.ResultsThe mean age of the 80 identified cases was 65.7 years, and 63 patients were male. Preoperative echocardiograms showed a mean ejection fraction of 25.2% and mean left ventricular diameters in diastole/systole of 64.5/56.9 mm, respectively. Mitral valve replacement was performed in 39 cases, and mitral valve plasty in 41 cases. The most common concomitant procedures were coronary artery bypass grafting and tricuspid valve surgery (41.3% each). Mitral regurgitation improved significantly from 3.5 to 0.83, and no operative or in‐hospital deaths were encountered. Long‐term results showed actual 1‐, 3‐ and 5‐year survival rates of 93.1%, 80.0%, and 64.7%, respectively (mean follow‐up, 1264 days).ConclusionsEarly results of this study were good and long‐term results were acceptable. Our results suggest that mitral valve surgery is feasible for secondary mitral valve regurgitation even in dilated, damaged hearts.

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Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study

Cited by 3 publications

References 24 publications

Objectives, design and main findings until 2020 from the Rotterdam Study

Objectives, design and main findings until 2020 from the Rotterdam Study

Numerical analysis of stenoses severity and aortic wall mechanics in patients with supravalvular aortic stenosis

Early and long‐term results of surgery for secondary mitral regurgitation with a damaged heart

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