Measures of nocturnal oxyhemoglobin desaturation in children with neuromuscular disease or Prader‐Willi syndrome

Abstract

ObjectivesEvidence for nocturnal oximetry interpretation in patients with abnormal neuromuscular function is limited. We aimed to compare children with neuromuscular disease (NMD) or Prader‐Willi syndrome (PWS) to otherwise healthy subjects with obstructive sleep‐disordered breathing (SDB) or without respiratory disorder (controls) regarding nocturnal oximetry parameters.MethodsWe analyzed recordings from children with: (a) NMD; (b) PWS; (c) snoring and adenotonsillar hypertrophy and/or obesity (SDB); and (d) controls. Outcomes included: (a) basal SpO2; (b) proportions of subjects with McGill oximetry score (MOS) >1 (clusters of desaturations); and (c) desaturation index (SpO2 drops ≥3%/h‐ODI3).ResultsData of 12 subjects with NMD (median age, 5.2 years; IQR, 2.7, 8.2), 14 children with PWS (5 years; 2.3, 6.9), 21 children with SDB (5.8 years; 4.6, 9.6), and 20 controls (6.2 years; 5.4, 11.2) were analyzed. Children with NMD, PWS, and SDB had lower basal SpO2 than controls (95.6% [94.5%, 96.9%], 96.2% [95.1%, 97.4%], 96.1% [95.8%, 97.5%] vs 97.8% [97.2%, 97.9%], respectively; (P < .01). NMD and PWS showed the greatest negative effect on basal SpO2 (P < .05). Children with SDB or PWS had a higher risk of MOS >1 than patients with NMD (OR, 25.9 [95% CI, 3.4‐200.4] and 9.5 [1.5‐62.6]). NMD, PWS, and SDB were similar regarding ODI3, which was elevated compared to ODI3 in controls (P < .05). Frequent desaturations predominated in NMD, while periods of sustained desaturation were noted in NMD and PWS.ConclusionPWS and NMD have a negative effect on basal SpO2, while clusters of desaturations are prevalent in patients with PWS or obstructive SDB.

Is it Feasible to Use a Low-Cost Wearable Sensor for Heart Rate Monitoring within an Upper Limb Training in Spinal Cord Injured Patients?: A Pilot Study

“…In the present study, the application Mi Fit, running under Android, was used for monitoring the HR. Measurements obtained from XMB5 were compared to a positive control usually used in clinical setting for the monitoring of patients, the professional medical equipment Nonin LifeSense ® II (NLII), capnograph and pulse oximeter, with CE marking as medical device [ 18 , 19 , 20 ]. This system was simultaneously used on the same hand wearing the XMB5.…”

A interação entre achados polissonográficos, padrão genético e anatomia de via aérea superior na síndrome de Prader-Willi

“…(52) O que difere da faixa etária puberal, onde existe uma maior prevalência de apneia com caráter obstrutivo. (53) A ASC e a hipoxemia na infância são associadas com déficits neurocognitivos; e o tratamento precoce, mesmo com suplementação de oxigênio, deve ter benefícios nessas populações de alto risco na SPW. (54) A AOS nos pacientes SPW é mais prevalente tanto pelo quadro de hipotonia e obesidade, mas também pelo aumento das amígdalas e adenoide, fator muito comum e preocupante em algumas populações.…”