Measures of Fatigue in Patients With Rheumatic Diseases: A Critical Review

Elera-Fitzcarrald, Claudia; Rocha, J A; Burgos, Paula I.; Ugarte‐Gil, Manuel F.; Petri, Michelle; Alarcón, Graciela S.

doi:10.1002/acr.24246

Cited by 24 publications

(17 citation statements)

References 223 publications

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“…The narrative feasibility analysis revealed that fatigue is most common in autoimmune diseases, intestinal bowel diseases, neurological diseases, and cancer [ 31 , 32 , 33 , 34 ]. Shared features of these diseases are inflammation and oxidative stress, which reinforce each other.…”

Section: Discussionmentioning

confidence: 99%

“…First observations point to IgG autoantibodies that are widely associated with myopathies, vasculitis, and antiphospholipid syndromes in SARS-CoV-2 infected subjects [ 51 ]. The observation of autoimmune antibodies is interesting, as fatigue is a known major problem in autoimmune diseases such as multiple sclerosis [ 37 , 52 ], rheumatoid arthritis [ 33 , 53 ], diabetes mellitus type 1 [ 54 ], systemic lupus erythematosus [ 39 ], and inflammatory bowel diseases [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

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Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue

Vollbracht

Kraft²

2021

Nutrients

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Fatigue is common not only in cancer patients but also after viral and other infections. Effective treatment options are still very rare. Therefore, the present knowledge on the pathophysiology of fatigue and the potential positive impact of treatment with vitamin C is illustrated. Additionally, the effectiveness of high-dose IV vitamin C in fatigue resulting from various diseases was assessed by a systematic literature review in order to assess the feasibility of vitamin C in post-viral, especially in long COVID, fatigue. Nine clinical studies with 720 participants were identified. Three of the four controlled trials observed a significant decrease in fatigue scores in the vitamin C group compared to the control group. Four of the five observational or before-and-after studies observed a significant reduction in pre–post levels of fatigue. Attendant symptoms of fatigue such as sleep disturbances, lack of concentration, depression, and pain were also frequently alleviated. Oxidative stress, inflammation, and circulatory disorders, which are important contributors to fatigue, are also discussed in long COVID fatigue. Thus, the antioxidant, anti-inflammatory, endothelial-restoring, and immunomodulatory effects of high-dose IV vitamin C might be a suitable treatment option.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue

Vollbracht

Kraft²

2021

Nutrients

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“…To evaluate fatigue, we used the Fatigue Assessment Scale (FAS), as it measures all aspects of fatigue, representing both physical and mental symptoms, independently from depression and neuroticism. Because of its psychometric properties, brevity, and ease of administration, the FAS is a valuable tool for assessing fatigue, and can be used in clinical research as a validated fatigue assessment measure [ 17 ]. It was shown that FAS had good responsiveness in chronic hepatitis C [ 18 ], and is suggested to be used for fatigue measurement in patients with chronic liver diseases [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Reduced Quality of Life in Patients with Non-Alcoholic Fatty Liver Disease May Be Associated with Depression and Fatigue

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is often thought of as clinically asymptomatic. However, many NAFLD patients complain of fatigue and low mood, which may affect their quality of life (QoL). This may create a barrier to weight loss and hinder the achievement of NAFLD therapy goals. Our study aimed to evaluate the QoL in NAFLD patients vs. healthy volunteers, and to analyze likely influencing factors. From March 2021 through December 2021, we enrolled 140 consecutive adult subjects (100 NAFLD patients and 40 controls). Overall, 95 patients with NAFLD and 37 controls were included in the final analysis. Fatty liver was diagnosed based on ultrasonographic findings. We employed 36-Item Short Form Health Survey (SF-36) to evaluate QoL, Hospital Anxiety and Depression Scale (HADS) to identify anxiety and/or depression, and Fatigue Assessment Scale (FAS) to measure fatigue. NAFLD patients had significantly lower physical component summary scores, as well as significantly higher HADS-D scores, compared with the control group (Mann-Whitney U criterion = 1140.0, p = 0.001 and U = 1294.5, p = 0.022, respectively). Likewise, fatigue was more common in NAFLD patients (χ2 = 4.008, p = 0.045). Impaired QoL was significantly associated with fatigue (FAS score ≥ 22, p < 0.001) and depression (HADS-D ≥ 8, p < 0.001). In conclusion, NAFLD patients had significantly poorer QoL vs. controls, in particular with respect to the physical component of health. Impaired QoL may be associated with fatigue and depression, and together they may interfere with increased physical activity and lifestyle modifications in patients with NAFLD.

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“…The range on the HAQ is 0 (indicating no functional limitation) to 3 (complete disability) (28). Pain and fatigue were quantified using visual analog scales (VAS), where 0 indicates no pain or fatigue and 10 indicates the worst pain or fatigue imaginable (29,30). Change in physical function, pain, and fatigue were calculated as the difference between the scores from the baseline to follow-up visits.…”

Section: Significance and Innovationsmentioning

confidence: 99%

Examining Rehabilitation Dose in Adults With Rheumatoid Arthritis: Association With Baseline Factors and Change in Clinical Outcomes

Thoma

Wellsandt

Wipfler

et al. 2023

Arthritis Care & Research

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Objective. To evaluate the association of baseline factors with rehabilitation dose and the association of rehabilitation dose with meaningful change in physical function, pain, and fatigue over 6 months among adults with rheumatoid arthritis (RA).Methods. Using data from the National Databank for Rheumatic Diseases registry, we extracted baseline characteristics and self-reported physical function (Health Assessment Questionnaire), pain (visual analog scale [VAS]), fatigue (VAS), rehabilitation dose (low: 1-2 visits, medium: 3-8 visits, high: >8 visits), and follow-up outcomes 6 months later. Changes in clinical outcomes were categorized as improved, no change, or worsened. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) using proportional odds logistic regression models to examine the association of the baseline factors with rehabilitation dose and the association of rehabilitation dose with changes in clinical outcomes, adjusting for potential confounders.Results. The sample included 1,381 adults with a new episode of rehabilitation (dose: low 27%, medium 42%, high 31%). Worse baseline physical function (adjusted OR 1.29 [95% CI 1.04-1.60]), but not pain (adjusted OR 1.04 [95% CI 0.99-1.10]) or fatigue (adjusted OR 0.98 [95% CI 0.93-1.03]), were associated with a higher rehabilitation dose. A high rehabilitation dose was associated with a favorable change in physical function ), pain ), and fatigue (OR 1.45 [95% CI 1.06-1.99]) compared to a low dose; only the association with physical function change persisted in adjusted models (adjusted OR 1.41 [95% CI 1.03-1.92]).Conclusion. Using real-world data, this study supports a higher rehabilitation dose to improve physical function in adults with RA.

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Measures of Fatigue in Patients With Rheumatic Diseases: A Critical Review

Cited by 24 publications

References 223 publications

Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue

Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue

Reduced Quality of Life in Patients with Non-Alcoholic Fatty Liver Disease May Be Associated with Depression and Fatigue

Examining Rehabilitation Dose in Adults With Rheumatoid Arthritis: Association With Baseline Factors and Change in Clinical Outcomes

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