2017
DOI: 10.1371/journal.pone.0186716
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Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review

Abstract: BackgroundInsomnia disorder is a widespread sleep disorder with a prevalence of approximately 10%. Even though the link between insomnia and cardiovascular activity is not exactly clear, it is generally assumed that cardiovascular autonomic modifications could occur as a result of sleeplessness, or, alternatively, that autonomic alterations could be an expression of a hyper-arousal state. This review investigates whether cardiovascular measures are different between insomniacs and controls.MethodsElectronic da… Show more

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Cited by 37 publications
(27 citation statements)
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References 111 publications
(326 reference statements)
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“…Abnormalities in autonomic modulation may in part explain the elevated risk of cardiovascular disease in insomniacs (61, 62). Studies on heart rate variability and insomnia reveal increased sympathetic activity while awake before sleep and during stage-2 non-REM sleep which support the theory that autonomic hyper-arousal is a major cause of insomnia (63, 64). This state of increased nocturnal autonomic arousal in insomnia patients who are simultaneously exhausted is known in sleep clinics as “tired but wired” (56).…”
Section: Stress and The Autonomic Nervous Systemsupporting
confidence: 55%
“…Abnormalities in autonomic modulation may in part explain the elevated risk of cardiovascular disease in insomniacs (61, 62). Studies on heart rate variability and insomnia reveal increased sympathetic activity while awake before sleep and during stage-2 non-REM sleep which support the theory that autonomic hyper-arousal is a major cause of insomnia (63, 64). This state of increased nocturnal autonomic arousal in insomnia patients who are simultaneously exhausted is known in sleep clinics as “tired but wired” (56).…”
Section: Stress and The Autonomic Nervous Systemsupporting
confidence: 55%
“…Melatonin administration in otherwise melatonin-nonproficient patients induced a drastic increase of HRV indices as measures of autonomic cardiac modulation. Accumulating evidence indicates that autonomic cardiac disfunction is implicated as a pathophysiological link between sleep disorders and their physiological consequences (25)(26)(27)(28). Polysomnogram HRV as a measure of cardiac autonomic modulation is a noninvasive, automatable biomarker of cardiovascular risk (29), and is independently associated with carotid atherosclerosis (30).…”
Section: Discussionmentioning
confidence: 99%
“…In a small number of participants the AHI was considerably over- or underestimated. Considerable AHI overestimation mainly occurred in participants with comorbid sleep disorders that have an impact on cardiovascular features, such as insomnia and sleep-related movement disorders 3436 . The effect of these sleep disorders on the features is also confirmed by the relatively large amount of epochs with movements that are misdetected by our method as RE-epochs.…”
Section: Discussionmentioning
confidence: 99%