Measures of adherence to epilepsy treatment: Review of present practices and recommendations for future directions

Abstract

SUMMARYEpilepsy is one of the most common neurological disorders worldwide, and the majority of people with epilepsy who live in developed countries manage their condition with antiseizure medication. Surprisingly, therefore, the literature on epilepsy does not document a comprehensive investigation of patient adherence to medication treatment. This paper reviews existing literature on direct and indirect measures of adherence. Based on this review, areas in need for further research have been identified, including improvement of self-report instruments, consideration of cultural factors, attention to patient literacy or numeracy levels, and inclusion of patient-guided measures. While no single method of determining adherence has proved effective, combining direct and indirect measures in a patient-guided, culturally competent atmosphere may increase adherence to treatment, improving health outcomes for this population.

Self-report measures of medication adherence behavior: recommendations on optimal use

“…In the context of clinical research, proper interpretation of proof-of-concept trials testing new pharmacologic regimens requires valid adherence data, because any null findings may stem from poor adherence rather than a lack of drug efficacy. Research designed to understand and promote medication adherence also requires precise methods of adherence assessment.Among many approaches to assessing medication adherence, patient self-report measures remain the most common method [1][2][3][4][5][6]. These measures are defined by asking respondents to characterize their medication adherence behavior.…”

“…Among many approaches to assessing medication adherence, patient self-report measures remain the most common method [1][2][3][4][5][6]. These measures are defined by asking respondents to characterize their medication adherence behavior.…”

The psychodiagnostic aspects of the compliance with treatment in the course of medical rehabilitation

“…Представляется важным отметить определенную терминологическую разно-голосицу, вызванную параллельным употреблением нескольких близких по содержанию понятий: «compliance» («комплаенс», «согласие»), «concordance» («согласие с лечением»), «adherence to therapy» («приверженность к терапии», «соблюдение указа-ний врача»), «persistence» («постоянство»), «drug holidays» («отдых от лекарств») [3][4][5][6], «терапевтиче-ское сотрудничество» [7].…”

Analysis of reasons for low adherence to antiepileptic therapy in patients with symptomatic epilepsy

“…patient compliance, что означает «соблюдение больным режима и схемы лече-ния». Считается, что от 30 до 40% пациентов, страдающих эпилепсией, не во всем следуют советам врача [3][4][5][6]. Нару-шение комплаентности приводит к неблагоприятным исхо-дам эпилепсии.…”