Measures for disinfection and sterilization as the most significant concept in health care infection control system in Russia

Shestopalov, Nikolay Vladimirovich; Акимкин, В. Г.; Пантелеева, Л. Р.; Fedorova, L. S.; Абрамова, Ирина Михайловна

doi:10.1186/2047-2994-4-s1-p47

Cited by 2 publications

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“…1a ). By that time, the use of our IPC program to prevent HAIs in the ICU became a paradigm-shifting solution across Russia as HAI prevention strategies had previously remained unchanged for years and had become outdated [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Implementing an infection control and prevention program decreases the incidence of healthcare-associated infections and antibiotic resistance in a Russian neuro-ICU

Ershova

Савин

Kurdyumova

et al. 2018

Antimicrob Resist Infect Control

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BackgroundThe impact of infection prevention and control (IPC) programs in limited resource countries such as Russia are largely unknown due to a lack of reliable data. The aim of this study is to evaluate the effect of an IPC program with respect to healthcare associated infection (HAI) prevention and to define the incidence of HAIs in a Russian ICU.MethodsA pioneering IPC program was implemented in a neuro-ICU at Burdenko Neurosurgery Institute in 2010 and included hand hygiene, surveillance, contact precautions, patient isolation, and environmental cleaning measures. This prospective observational cohort study lasted from 2011 to 2016, included high-risk ICU patients, and evaluated the dynamics of incidence, etiological spectrum, and resistance profile of four types of HAIs, including subgroup analysis of device-associated infections. Survival analysis compared patients with and without HAIs.ResultsWe included 2038 high-risk patients. By 2016, HAI cumulative incidence decreased significantly for respiratory HAIs (36.1% vs. 24.5%, p-value = 0.0003), urinary-tract HAIs (29.1% vs. 21.3%, p-value = 0.0006), and healthcare-associated ventriculitis and meningitis (HAVM) (16% vs. 7.8%, p-value = 0.004). The incidence rate of EVD-related HAVM dropped from 22.2 to 13.5 cases per 1000 EVD-days. The proportion of invasive isolates of Klebsiella pneumoniae and Acinetobacter baumannii resistant to carbapenems decreased 1.7 and 2 fold, respectively. HAVM significantly impaired survival and independently increasing the probability of death by 1.43.ConclusionsThe implementation of an evidence-based IPC program in a middle-income country (Russia) was highly effective in HAI prevention with meaningful reductions in antibiotic resistance.Electronic supplementary materialThe online version of this article (10.1186/s13756-018-0383-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Implementing an infection control and prevention program decreases the incidence of healthcare-associated infections and antibiotic resistance in a Russian neuro-ICU

Ershova

Савин

Kurdyumova

et al. 2018

Antimicrob Resist Infect Control

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“…An important advantage of guanidine derivatives is their propensity for prolonged action. These compounds have a wide spectrum of activity, including against bacteria from the ESKAPE group [21] and viruses [22], as well as low toxicity to humans and animals [23]. Compared to other compounds, guanidine derivatives are promising and have practically no drawbacks; therefore, their use as alternatives to antibiotics and antiseptics that have lost their relevance due to resistance is recommended.…”

Section: Types Of Antisepticsmentioning

confidence: 99%

Ho Chi Minh City University of Technology (HCMUT); Vietnam National University Ho Chi Minh City (VNU-HCM)

2022

Fine Chem. Technol.

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Objectives. The study aimed to analyze the current antiseptics and disinfectants, explore the possibility of synthesizing various antiseptics including oligohexamethylene guanidine hydrochloride (OHMG-HC) using microfluidic technology, and investigate the main synthesis parameters affecting the properties of the resulting product.Methods. This article presented a review of literature sources associated with investigations of antimicrobial resistance, the uses of agents based on polyhexamethylene guanidine hydrochloride, oligohexamethylene guanidine hydrochloride, and other salts, obained using modern synthesis technologies with microreactors.Results. The relevance of developing production technologies for the “OHMG-HC branched” substance was determined. The microfluidic method for the synthesis of polymers, and its application prospects for obtaining the target substance were compared with the existing methods. Advantages of the microfluidic method were indicated.Conclusions. Microreactor technologies allow for more accurate control of the conditions of the polycondensation reaction of the starting monomers and increase the yield and selectivity of the oligomers obtained, leading to an increase in the product purity and process efficiency, in contrast with other known methods. The use of microreactor technologies for the synthesis of branched oligohexamethylene guanidine hydrochloride products is a promising strategy.

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Measures for disinfection and sterilization as the most significant concept in health care infection control system in Russia

Cited by 2 publications

References 0 publications

Implementing an infection control and prevention program decreases the incidence of healthcare-associated infections and antibiotic resistance in a Russian neuro-ICU

Implementing an infection control and prevention program decreases the incidence of healthcare-associated infections and antibiotic resistance in a Russian neuro-ICU

Ho Chi Minh City University of Technology (HCMUT); Vietnam National University Ho Chi Minh City (VNU-HCM)

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