Abstract:8 Ionotropic glutamate receptors (iGluRs) are ligand gated ion channels that mediate excitatory 9 synaptic transmission in the central nervous system (CNS). Desensitization of the AMPA-10 subtype following glutamate binding appears critical for brain function, and involves 11 rearrangement of the ligand binding domains (LBDs). Recently, several full-length structures 12 of iGluRs in putative desensitized states were published. These structures indicate movements 13 of the LBDs that might be trapped by cysteine… Show more
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