The results of the calculation of atmospheric transmission spectra and modeling of lidar signals in the informative range of greenhouse gases sounding (CO 2 , H 2 O) on horizontal tropospheric paths by using a two-channel infrared lidar system under development are presented. It is shown that the spectral range of operation of the lidar system 4878-4894 cm -1 (2043-2050 nm) is preferable for simultaneous probing of CO 2 and H 2 O, in which the level of lidar signals is in the range of 10 -6 -10 -10 W and exceeds the equivalent noise power photodetector. Several configurations of the lidar system with the generation of nanosecond radiation pulses in the selected informative range of sounding the trace gases under study are proposed.