Measurements of surface concentration and charge number per adsorbed molecule for a thiolipid monolayer tethered to the Au(111) surface by a long hydrophilic chain

Seenath, Ryan; Leitch, J. Jay; Su, Zhixun; Faragher, Robert J.; Schwan, Adrian L.; Lipkowski, Jacek

doi:10.1016/j.jelechem.2016.12.043

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…The potential of zero charge is influenced by the adsorption of anions and depends on orientation of surface dipoles . Since the surface concentration of lipids is known, the charge densities could be used to calculate the electrosorption valency and charge number on the lipid using the procedure described in. ,− …”

Section: Resultsmentioning

confidence: 99%

Electric-Field-Driven Molecular Recognition Reactions of Guanine with 1,2-Dipalmitoyl-sn-glycero-3-cytidine Monolayers Deposited on Gold Electrodes

Álvarez-Malmagro

Leitch

et al. 2019

Langmuir

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Monolayers of 1,2-dipalmitoyl-sn-glycero-3-cytidine were incubated with guanine in a 0.1 M NaF electrolyte at the surface of a Langmuir trough and transferred to gold (111) electrodes using the Langmuir−Schaefer technique. Chronocoulometry and photon polarization modulation infrared reflection absorption spectroscopy were employed to investigate the influence of the static electric field on the orientation and conformation of the cytidine nucleolipid molecules on the metal surface in the presence of guanine and to monitor the molecular recognition of guanine with the cytosine moiety. When the monolayer is exposed to guanine solutions, the cytosine moiety binds to the guanine residue in either a Watson−Crick complex at positively charged electrode surfaces or a noncomplexed state at negative surface charges. The positive electrostatic field causes the cytosine moiety and the cytosine−guanine complex to adopt a nearly parallel orientation with respect to the plane of the monolayer with a measured tilt angle of ∼10°. The parallel orientation is stabilized by the interactions between the permanent dipole of the cytosine moiety or the Watson−Crick complex and the static electric field. At negative charge densities, the tilt of the cytosine moiety increases by ∼15−20°, destabilizing the complex. Our results demonstrate that the static electric field has an influence on the molecular recognition reactions between nucleoside base pairs at the metal−solution interface and can be controlled by altering the surface charge at the metal.

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Section: Resultsmentioning

confidence: 99%

Electric-Field-Driven Molecular Recognition Reactions of Guanine with 1,2-Dipalmitoyl-sn-glycero-3-cytidine Monolayers Deposited on Gold Electrodes

Álvarez-Malmagro

Leitch

et al. 2019

Langmuir

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“…Experimental data for Au(111) reveal that E p depends on thiol concentration, and it is shifted negatively by 0.057 V/decade when the thiol concentration is increased, confirming that the desorption is a one-electron process [12]. Note that reaction (1) is a solvent substitution reaction, which results in a significant change in the electrode capacitance, and a significant change in the potential of zero total charge [13][14][15]. This fact induced errors in the estimation of θ from q values due to the failure to account for the double-layer charging contribution.…”

Section: Introductionmentioning

confidence: 82%

The electrochemical stability of thiols on gold surfaces

Salvarezza

Carro

2018

Journal of Electroanalytical Chemistry

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In this paper we present a comparative analysis of the electrochemical stability of alkanethiols, aromatic and heterocyclic thiols on the Au(111) and Au(100) faces in relation to the theoretical energetic data. The peak potential and surface coverage are used as the key parameters to estimate the electrochemical stability while work function changes, adsorption energies and surface free energies calculated from periodic DFT, including van der Waals interactions, are used for the theoretical estimation. We find that the peak potentials do not correlate with work function changes and adsorption energies in particular for aromatic and heterocyclic thiols. In contrast, the reductive desorption potentials for the different thiols show a good correlation with the surface free energy of the SAMs estimated by density functional theory calculations. Surface coverage is a key factor that controls reductive desorption through van der Waals interactions.

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“…The immersion method, described by Hamm et al [47], was firstly applied by Ramirez et al [48] to determine Epzfc of thiols monolayers covered gold electrode. Su et al [49] and Seenath et al [50] employed the immersion method to determine Epzfc at the gold electrode covered with the assembled tBLM. In the present work, the gA-DPhPC (10:90) / DPTL tBLM covered electrode was dried in a stream of argon for about 30 min and then slowly brought in contact with the electrolyte at a constant electrode potential.…”

Section: Electrochemical Measurementsmentioning

confidence: 99%

Gramicidin A ion channel formation in model phospholipid bilayers tethered to gold (111) electrode surfaces

Leitch

Faragher

et al. 2017

Electrochimica Acta

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Measurements of surface concentration and charge number per adsorbed molecule for a thiolipid monolayer tethered to the Au(111) surface by a long hydrophilic chain

Cited by 8 publications

References 25 publications

Electric-Field-Driven Molecular Recognition Reactions of Guanine with 1,2-Dipalmitoyl-sn-glycero-3-cytidine Monolayers Deposited on Gold Electrodes

Electric-Field-Driven Molecular Recognition Reactions of Guanine with 1,2-Dipalmitoyl-sn-glycero-3-cytidine Monolayers Deposited on Gold Electrodes

The electrochemical stability of thiols on gold surfaces

Gramicidin A ion channel formation in model phospholipid bilayers tethered to gold (111) electrode surfaces

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