Measurements of platinum electrode potential in blood and blood plasma and serum

Khubutiya, M. Sh.; Евсеев, А. К.; Колесников, В. А.; Goldin, Mark M.; Давыдов, А. Д.; Volkov, Alexander G.; Степанов, А. А.

doi:10.1134/s1023193510050071

Cited by 23 publications

(13 citation statements)

References 12 publications

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“…It was also shown that HBO treatment led to a negative shift in RP. Thus, upon HBO, the plasma RP in patients with acute cerebral pathology became closer to the potential range typical of healthy individuals, which was determined in our earlier work [15]. It was also observed that the RP values meas ured after HBO fell within the potential range -23 -36 mV (Fig.…”

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confidence: 56%

An Electrochemical Apparatus for Determination of the Redox Potential of Blood Plasma and Serum

et al. 2016

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A device for determination of the redox potential of blood plasma and serum was developed. The redox potential is determined by electrochemical measurements of the Pt electrode potential in the tested medium. Measurements are performed in an open circuit. Sixty three healthy volunteers and 86 patients, with head injury and trans planted kidneys, as well as resuscitated patients with acute severe injuries, were tested. The obtained results formed a basis for development of diagnostic and prognostic criteria for treatment of such patients.

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confidence: 56%

An Electrochemical Apparatus for Determination of the Redox Potential of Blood Plasma and Serum

et al. 2016

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“…These are complex mixtures of redox active components, and any measured potential is a mixed potential not attributable to only one molecule. Described in some detail by Khubutiya et al., the observed open circuit potential for these fluids is dependent on measurement method and sample preparation 27. For example, using a platinum electrode versus a gold electrode results in a difference on the order of 70 mV in observed open circuit potential 27, 28.…”

Section: Resultsmentioning

confidence: 99%

“…Described in some detail by Khubutiya et al., the observed open circuit potential for these fluids is dependent on measurement method and sample preparation 27. For example, using a platinum electrode versus a gold electrode results in a difference on the order of 70 mV in observed open circuit potential 27, 28. Blood serum and heparinized blood serum are also different by about 50 mV using the same measurement apparatus 27.…”

Section: Resultsmentioning

confidence: 99%

“…For example, using a platinum electrode versus a gold electrode results in a difference on the order of 70 mV in observed open circuit potential 27, 28. Blood serum and heparinized blood serum are also different by about 50 mV using the same measurement apparatus 27. Without a widely agreed upon measurement protocol there is no true value for open circuit redox potential to discuss.…”

Section: Resultsmentioning

confidence: 99%

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Highly Crystalline Lithium Titanium Oxide Sheets Coated with Nitrogen‐Doped Carbon enable High‐Rate Lithium‐Ion Batteries

Han

et al. 2014

ChemSusChem

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Sheets of Li4Ti5O12 with high crystallinity are coated with nitrogen-doped carbon (NC-LTO) using a controlled process, comprising hydrothermal reaction followed by chemical vapor deposition (CVD). Acetonitrile (CH3 CN) vapor is used as carbon and nitrogen source to obtain a thin coating layer of nitrogen-doped carbon. The layer enables the NC-LTO material to maintain its sheet structure during the high-temperature CVD process and to achieve high crystallinity. Doping with nitrogen introduces defects into the carbon coating layer, and this increased degree of disorder allows fast transportation of lithium ions in the layer. An electrode of NC-LTO synthesized at 700 °C exhibits greatly improved rate and cycling performance due to a markedly decreased total cell resistance and enhanced Li-ion diffusion coefficient (D(Li)). Specific capacities of 159.2 and 145.8 mA h g(-1) are obtained using the NC-LTO sheets, at charge/discharge rates of 1 and 10 C, respectively. These values are much higher than values for LTO particles did not undergo the acetonitrile CVD treatment. A capacity retention value as high as 94.7% is achieved for the NC-LTO sheets after 400 cycles in a half-cell at 5 C discharge rate.

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“…In one case, the biofouling issue was addressed by using an electrochemical pretreatment to desorb the adsorbed proteins just prior to measurement of OCP. 33 Most other work does not address this problem and the impact it may have on the observed potentiometric response. Given the results described above, a better alternative may involve the use of NPG.…”

Section: Resultsmentioning

confidence: 99%

Potentiometric Measurements in Biofouling Solutions: Comparison of Nanoporous Gold to Planar Gold

Farghaly

Lam

Freeman

et al. 2015

J. Electrochem. Soc.

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Potentiometric redox measurements were made in solutions of increasing biological complexity starting with buffer solutions containing either potassium ferri/ferrocyanide or ascorbic acid and finishing with plasma and blood. When the concentration of ferri/ferrocyanide was high (∼0.2 mM), both biofouled planar and nanoporous gold electrodes gave Nernstian slopes of 55-59 mV. However, at or below a critical concentration (≤ 0.1 mM), ∼20% loss in sensitivity was observed at planar gold in contrast to nanoporous gold where Nernstian behavior was retained. For ascorbic acid, a Nernst slope of −41 mV was observed at biofouled nanoporous gold electrodes. In contrast, biofouled planar gold electrodes failed to give any potentiometric redox response. At all concentrations studied, cyclic voltammetric measurements on biofouled electrodes revealed significant impairment of faradaic electroactivity at planar gold electrodes while no impairment was shown at nanoporous gold. These results indicate that nanoporous gold is an ideal electrode material to use when making both potentiometric and cyclic voltammetric measurements, particularly in complex solutions containing relatively low concentrations of redox molecules. As proof of concept, the redox potential of plasma and blood has been measured using nanoporous and planar gold electrodes and their values compared. Potentiometry is a technologically simple and inexpensive approach to obtain important information about the redox state of a system and/or the concentration of ions in solution.1,2 The measurement itself is simple in that all that is needed is a high impedance voltammeter, a stable reference electrode, and a suitable indicating electrode. In contrast to voltammetric measurements, no current flows, and the concentration of the redox species in solution does not change nor does the indicating electrode surface become altered as a potential is not applied. Likely the most popular potentiometric measurement is the measurement of pH using an ion-selective electrode that incorporates a thin membrane responsive to the activity of protons in solution. 3For the work described herein, the indicating electrode is an inert metallic redox electrode that is purposely designed to be nonselective and will 'ideally' respond to all redox active species in solution able to exchange electrons with the metallic surface.1,2 When the indicator electrode is immersed in solution, it will equilibrate electrochemically with the dissolved redox species and a potential will develop at its surface. The measured potential is governed by factors such as (1) the redox species present, (2) their concentrations (activities), and (3) the rate of electron exchange with the electrode.2,4,5 Such redox measurements have been used to characterize the redox state of solutions with a complex matrix including milk, cheese, sludge, water and biological systems. [6][7][8][9][10][11][12][13] An important and often neglected factor in the measurement of redox potential is the nature of the electrode surface, pa...

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Measurements of platinum electrode potential in blood and blood plasma and serum

Cited by 23 publications

References 12 publications

An Electrochemical Apparatus for Determination of the Redox Potential of Blood Plasma and Serum

An Electrochemical Apparatus for Determination of the Redox Potential of Blood Plasma and Serum

Highly Crystalline Lithium Titanium Oxide Sheets Coated with Nitrogen‐Doped Carbon enable High‐Rate Lithium‐Ion Batteries

Potentiometric Measurements in Biofouling Solutions: Comparison of Nanoporous Gold to Planar Gold

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