Measurements of jugular, portal, femoral, and calf vein cross-sectional area for the assessment of venous blood redistribution with long duration spaceflight (Vessel Imaging Experiment)

Arbeille, Philippe; Provost, Romain; Zuj, Kathryn; Vincent, Nicole

doi:10.1007/s00421-015-3189-6

Cited by 65 publications

(48 citation statements)

References 12 publications

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“…Angioedema, a rare side effect associated with ACEIs and ARBs, results from increased levels of bradykinin, which increases capillary permeability 5,30 During spaceflight, astronauts develop venous blood pooling in the absence of gravity, particularly in the pelvic, splanchnic, and cephalic areas. 3 It is possible that increased levels of bradykinin due to ACEI/ARB use could transform this venous pooling to clinically relevant edema. Given the dangers of prophylactic use regarding edema and renal perfusion, ACEIs and ARBs would likely make poor prophylactic agents for the astronaut population.…”

Section: Resultsmentioning

confidence: 99%

Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight

McLaughlin¹,

Donoviel²,

Jones³

2017

Aerospace Medicine and Human Performance

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Background In the space environment, the traditional radioprotective principles of time, distance, and shielding become difficult to implement. Additionally, the complex radiation environment inherent in space, the chronic exposure timeframe, and the presence of numerous confounding variables complicate the process of creating appropriate risk models for astronaut exposure. Pharmaceutical options hold tremendous promise to attenuate acute and late effects of radiation exposure in the astronaut population. Pharmaceuticals currently approved for other indications may also offer radiation protection, modulation, or mitigation properties along with a well-established safety profile. Currently there are only three agents which have been clinically approved to be employed for radiation exposure, and these only for very narrow indications. This review identifies a number of agents currently approved by the U.S. Food and Drug Administration (FDA) which could warrant further investigation for use in astronauts. Specifically, we examine preclinical and clinical evidence for statins, nonsteroidal anti-inflammatory drugs (NSAIDs), angiotensin converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), metformin, calcium channel blockers, β adrenergic receptor blockers, fingolimod, N-acetylcysteine, and pentoxifylline as potential radiation countermeasures.

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Section: Resultsmentioning

confidence: 99%

Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight

McLaughlin¹,

Donoviel²,

Jones³

2017

Aerospace Medicine and Human Performance

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“…Research from the Canadian Space Agency suggests that despite exercise regimes in-flight, cardiovascular deconditioning and arterial stiffness is a common manifestation in astronauts returning to Earth [39]. Moreover as the pressure gradients associated with the arterial, venous and microcirculation are no longer present, fluid shift towards the thorax and head is associated with venous blood pooling in cephalic, splanchnic and pelvic regions [40]. As most drugs rely on the blood for distribution to the target tissues or organ, changes in blood parameters such a blood volume are likely to influence the pharmacodynamic activity of the medication and this may lead to loss of efficacy and accumulation of drug within a compartment [41].…”

Section: Cardiovascularmentioning

confidence: 99%

Ergonomic Challenges for Astronauts during Space Travel and the Need for Space Medicine

Braddock¹

2017

J Ergonomics

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“…Detect the interactions between peripheral and central cardiovascular responses through the effects on conduit artery diameter, wall thickness and redistribution of venous blood flow by vessel imaging (ultrasound imaging) 58,65,66 or MRI.…”

Section: What Are the In-flight Alterations In Cardiovascular Structumentioning

confidence: 99%

Towards human exploration of space: the THESEUS review series on cardiovascular, respiratory, and renal research priorities

et al. 2016

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International audienceThe THESEUS project (Towards Human Exploration of Space: aEUropean Strategy) was initiated within the seventh FrameworkProgramme by the European Commission. This project aimed toprovide a cross-cutting, life science-based roadmap for Europe’sstrategy towards human exploration of space, especially for deepspace missions and its relevance to applications on Earth. Toaddress these challenges, relevance of space research on thecardiovascular system, the lungs and kidneys, was discussed in anexpert group and its principal conclusions will be presented in thisarticle

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Measurements of jugular, portal, femoral, and calf vein cross-sectional area for the assessment of venous blood redistribution with long duration spaceflight (Vessel Imaging Experiment)

Cited by 65 publications

References 12 publications

Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight

Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight

Ergonomic Challenges for Astronauts during Space Travel and the Need for Space Medicine

Towards human exploration of space: the THESEUS review series on cardiovascular, respiratory, and renal research priorities

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