Measurements and modeling of the solubility of ergosterol in supercritical carbon dioxide

Cheng, Shueh-Hen; Yang, Fan-Chiang; Yang, Ya-Huey; Hu, Chi-Chih; Chang, Wen-Teng

doi:10.1016/j.jtice.2012.09.001

Cited by 34 publications

(15 citation statements)

References 27 publications

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“…The lowest yield (1.1%) was obtained with supercritical CO 2 extraction of the generated residue (1.7% of ReA) since it mostly extracted lipophilic compounds (ExB) and mushrooms have a low lipid content. Moreover, supercritical CO 2 exhibit a high selectivity enabling high recoveries of specific fatty acids, sterols and derivatives from fungal or other matrices . Nevertheless, the obtained yield was similar to those described in previous publications where SFE extractions were carried out directly from fruiting bodies indicating that SFE extractions could be also carried out using the residues obtained after the first extraction step.…”

Section: Resultssupporting

confidence: 84%

Extraction of bioactive compounds against cardiovascular diseases from Lentinula edodes using a sequential extraction method

Morales

Piris

Ruiz-Rodrı́guez

et al. 2018

Biotechnology Progress

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Three extraction methods were sequentially combined to obtain fractions from Lentinula edodes (shiitake mushrooms) containing bioactive compounds against cardiovascular diseases (CVDs). Fruiting bodies were first extracted with plain water, obtained residue was then submitted to supercritical fluid extraction (SFE) and remaining residue submitted to hot water extraction. Sequential design allowed reutilization of the nonextracted material as raw material for the successive extractions increasing extraction yields and separating interesting compounds. Obtained fractions contained different amounts of ß-glucans, chitins, eritadenine, lenthionine, ergosterol, proteins/peptides and phenolic compounds conferring them different bioactivities. Water soluble fractions showed high antioxidant activities (ABTS and DPPH scavenging capacity and reducing power), they were also able to inhibit one of the main enzymes involved in hypertension (angiotensin-I converting enzyme) and the key enzyme of cholesterol metabolism (3-hydroxy-3-methylglutaryl coenzyme A reductase). The latter inhibitory activity was also noticed in SFE extracts although ergosterol and other lipid-like molecules were isolated. Dietary fibers were separated in the third extraction. Therefore, with this sequential extraction procedure bioactive compounds against CVDs can be selectively separated from a single batch of shiitake powder. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 34:746-755, 2018.

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Section: Resultssupporting

confidence: 84%

Extraction of bioactive compounds against cardiovascular diseases from Lentinula edodes using a sequential extraction method

Morales

Piris

Ruiz-Rodrı́guez

et al. 2018

Biotechnology Progress

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“…Table 3 providing the CO 2 mole fraction (y 1 ) in the supercritical phase. According to Cheng et al, 17 the solubility of solute in the sc-CO 2 in terms of CO 2 mole fraction in the supercritical fluid phase is given by eq 1:…”

Section: Methodsmentioning

confidence: 99%

Equilibrium Solubilities of Diisooctyl Sebacate in Supercritical Carbon Dioxide

Yang

Chen

Wen³

et al. 2015

J. Chem. Eng. Data

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The extraction of base oil from waste lubricating oil is becoming the preferred way of handling used oil to protect the environment and conserve petroleum resources. Supercritical carbon dioxide extraction has become a potential technology for the regeneration of waste lubricant oil because carbon dioxide has high dissolving power, is nontoxic, nonflammable, and inexpensive. Since the equilibrium solubility data are important for supercritical extraction processes, in this study the equilibrium solubilities for one of the synthetic ester lubricant oils, diisooctyl sebacate [bis (2-ethylhexyl) sebacate], in supercritical carbon dioxide (sc-CO 2 ) were obtained at 313.2 K, 328.2 K, 343.2 K, 358.2 K and in a pressure range from 7.24 MPa up to 15.96 MPa. Oil solubility increased with pressure but decreased with temperature, providing sc-CO 2 with the highest oil solubility (82.1959 g/L) at 313.2 K and 13.96 MPa, which showed that the solubility is strongly dependent on the density of CO 2 . The experimental solubility results were correlated with three density-based models: Chrastil model, del Valle and Aguilera model, and the Adachi and Lu model. While all of the three models correlated the experimental data very well, the nonlinear equation of Adachi and Lu model showed the best fit.

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“…9 Cheng et al correlated the solubility data of ergosterol in supercritical carbon dioxide at high pressures by the Schmitt-Reid and Giddings models. 10 A model was developed for drug solubility in supercritical carbon dioxide using equation of state based on the the hole theory with molecular surface charge density by Sakabe et al 11 Asgarpour Khansary et al developed a new model for the empirical prediction of solute solubility in supercritical carbon dioxide. 12 Li et al investigated the solubilities of organic compounds in supercritical CO 2 using a modified solution model and expanded liquid model.…”

Section: Introductionmentioning

confidence: 99%

Correlation of the solubility of solid hydrocarbons in supercritical CO2 using different equations of state and mixing rules

Setoodeh

Ameri

2022

JSCS

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Supercritical extraction process is a technique which has been increasingly applied in various industries in recent years. Solubility determination in supercritical region is the key feature for this process. However, high expenses and time consuming experiments for this task obligates the need for process modeling. In this study, a thermodynamic model has been proposed to correlate the solubility of solid hydrocarbons, namely, 1-hexadecanol, 1-octadecanol, anthracene, benzoin, fluorene, hexamethylbenze-ne, mandelic acid, naphtalene, palmitic acid, phenanthrene, propyl 4-hydroxy-benzoate, pyrene and stearic acid in supercritical conditions, using Peng-Robinson (PR) and Soave-Redlich-Kwong (SRK) equations of state with one-parameter van der Waals (vdW1) and two-parameters (vdW2) and covolume dependent (CVD) mixing rules. For the above combination of equations of state and mixing rules, binary interaction parameters have been determined, utilizing the differential evolution optimization strategy. The validity of the model has been assessed by comparing the experimental solubility data with the results obtained from thermodynamic model based on Average Absolute Relative Deviation percent (AARD %). An empirical correlation is proposed for the correlation of the solid solubilities in supercritical CO2. For each compound, the constants of this equation are obtained in such a manner to correlate the solubility at different temperatures and pressures.

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Measurements and modeling of the solubility of ergosterol in supercritical carbon dioxide

Cited by 34 publications

References 27 publications

Extraction of bioactive compounds against cardiovascular diseases from Lentinula edodes using a sequential extraction method

Extraction of bioactive compounds against cardiovascular diseases from Lentinula edodes using a sequential extraction method

Equilibrium Solubilities of Diisooctyl Sebacate in Supercritical Carbon Dioxide

Correlation of the solubility of solid hydrocarbons in supercritical CO2 using different equations of state and mixing rules

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