Measurement of vascular tone and stroke volume baroreflex gain

Vaschillo, Evgeny; Vaschillo, Bronya; Buckman, Jennifer F.; Pandina, Robert J.; Bates, Marsha E.

doi:10.1111/j.1469-8986.2011.01305.x

Cited by 46 publications

(37 citation statements)

References 26 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, most criticisms of the LF/HF ratio highlight the lack of association of LF power with beta-adrenergic activity (41). However, the baroreflex is comprised of at least three related feedback loops, only one of which has been explicitly linked to LF power (40, 42). A major unexplored association is with the vascular limb of the baroreflex, which would be primarily alpha-adrenergic.…”

Section: Discussionmentioning

confidence: 99%

Racial Differences in Heart Rate Variability During Sleep in Women

Hall¹,

Middleton²,

Thayer³

et al. 2013

Psychosomatic Medicine

View full text Add to dashboard Cite

Background Heart rate variability (HRV) differs markedly by race, yet few studies have evaluated these relationships in women. Moreover, none have evaluated HRV during sleep, despite sleep's importance to cardiovascular health. Methods We addressed these gaps by examining HRV during sleep in African American, Chinese and white women (mean age 51.2 ± 2.2). Sleep and HRV during sleep (sHRV) were measured concurrently. Results Heart rate variability during stage 2 non-rapid eye movement (NREM) and rapid eye movement (REM) sleep differed significantly by race after adjusting for possible confounders. Normalized high frequency HRV was significantly lower in white compared to African American and Chinese participants (white NREM=0.35 ±.01, REM=0.23 ± .01; African American NREM=0.43 ± 0.02, REM=0.29 ± 0.02; Chinese NREM=0.47 ± 0.03, REM=0.33 ± 0.02; p’s<.001). The inverse was seen for low frequency power, with higher values in white compared to African American and Chinese participants (white NREM=0.66 ± .01, REM=0.77 ± .01; African American=NREM 0.58 ± 0.02, REM=0.71 ± 0.02; Chinese=0.53 ± 0.03, REM=0.68 ± 0.02; p’s<.010). Whites also exhibited higher low-to-high frequency HRV ratios during sleep compared to African American and Chinese women (white NREM=2.42 ± 1.07, REM=5.05 ± 1.07; African American NREM=1.69 ± 1.09, REM=3.51 ± 1.09; Chinese NREM=.35 ± 1.07, REM=2.88 ± 1.13; p’s<.001). Conclusions Race was robustly related to HRV during sleep. Compared to African American and Chinese women, whites exhibited decreased vagally-mediated control of the heart during sleep. Rresearch is needed to evaluate whether sHRV, including race differences, is prospectively associated with cardiovascular disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Racial Differences in Heart Rate Variability During Sleep in Women

Hall¹,

Middleton²,

Thayer³

et al. 2013

Psychosomatic Medicine

View full text Add to dashboard Cite

show abstract

“…Sensitivity was estimated as the average power of the transfer function in the low frequency range where coherence between systolic BP (input) and the output was > 0.5 (Cooke et al, 1999). Baroreflex sensitivities evaluate the magnitude of change in RRI, stroke volume, and pulse transit time to a 1 mmHg change in systolic BP (Maestri et al, 1998; Pitzalis et al, 1998; Vaschillo et al, 2002, 2012). …”

Section: Methodsmentioning

confidence: 99%

“…Rather, it can flexibly respond to challenge by changing stroke volume, vascular tone, and blood pressure (BP) variability in addition to or in lieu of changing HRV (Liu et al, 2004; Ma and Zhang, 2006; Rickards and Tzeng, 2014; Vaschillo et al, 2012). System redundancy ensures that the cardiovascular system can buffer itself against internal (e.g., cognitive emotional) and external (e.g., pharmacological) challenges, and thus protect the brain from stroke and the heart from myocardial infarction.…”

mentioning

confidence: 99%

“…These system elements (i.e., heart rate [HR], vascular tone) may work independently or in tandem to generate fine-grained, real-time adjustments to optimize cardiovascular responding. Importantly, variability in each of these processes is linked through the baroreflex system, which is comprised of multiple parallel, closed-loop branches that control BP through changes in HR (i.e., the HR baroreflex loop), stroke volume (i.e., the stroke volume baroreflex loop), and vascular tone (i.e., the vascular tone baroreflex loop) (Casadei et al, 1992; Eckberg and Sleight, 1992; Vaschillo et al, 2012; Yambe et al, 2009). In addition, the baroreflex controls sympathetic nervous system activity.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Immediate and Complex Cardiovascular Adaptation to an Acute Alcohol Dose

Buckman

Eddie

Vaschillo

et al. 2015

Alcoholism Clin & Exp Res

Self Cite

View full text Add to dashboard Cite

Background The detrimental effects of chronic heavy alcohol use on the cardiovascular system are well established and broadly appreciated. Integrated cardiovascular response to an acute dose of alcohol has been less studied. This study examined the early effects of an acute dose of alcohol on the cardiovascular system, with particular emphasis on system variability and sensitivity. The goal was to begin to understand how acute alcohol disrupts dynamic cardiovascular regulatory processes prior to the development of cardiovascular disease. Methods Healthy participants (N = 72, age 21 to 29) were randomly assigned to an alcohol, placebo, or no-alcohol control beverage condition. Beat-to-beat heart rate (HR) and blood pressure (BP) were assessed during a low-demand cognitive task prior to and following beverage consumption. Between-group differences in neurocardiac response to an alcohol challenge (blood alcohol concentration ~ 0.06 mg/dl) were tested. Results The alcohol beverage group showed higher average HR, lower average stroke volume, lower HR variability and BP variability, and increased vascular tone baroreflex sensitivity after alcohol consumption. No changes were observed in the placebo group, but the control group showed slightly elevated average HR and BP after beverage consumption, possibly due to juice content. At the level of the individual, an active alcohol dose appeared to disrupt the typically tight coupling between cardiovascular processes. Conclusions A dose of alcohol quickly invoked multiple cardiovascular responses, possibly as an adaptive reaction to the acute pharmacological challenge. Future studies should assess how exposure to alcohol acutely disrupts or dissociates typically integrated neurocardiac functions.

show abstract

“…The gains were calculated as the mean values of the corresponding transfer functions in the low frequency range (0.05 – 0.15 Hz) where coherence between the input and output functions was > 0.5 (Vaschillo, Vaschillo, Buckman, Pandina, & Bates, 2012). …”

Section: Methodsmentioning

confidence: 99%

The effects of sighing on the cardiovascular system

Vaschillo

Buckman

et al. 2015

Biological Psychology

Self Cite

View full text Add to dashboard Cite

Elicitation of high-amplitude oscillations in the cardiovascular system may serve to dampen psychophysiological reactivity to emotional and cognitive loading. Prior work has used paced breathing to impose clinically valuable high-amplitude ~0.1Hz oscillations. In this study, we investigated whether rhythmical sighing could likewise produce high-amplitude cardiovascular oscillations in the very low frequency range (0.003–0.05Hz). ECG, respiration, skin conductance, and beat-to-beat blood pressure were collected in 24 healthy participants during baseline, 0.1Hz paced breathing, and 0.02Hz paced sighing (1 sigh every 50 seconds, with normal breathing interspersed). Results showed that each sigh elicited a strong, well-defined reaction in the cardiovascular system. This reaction did not habituate when participants repeatedly sighed for 8.5 minutes. The result was a high-amplitude 0.02Hz oscillation in multiple cardiovascular parameters. Thus, paced sighing is a reliable method for imposing very low frequency oscillations in the cardiovascular system, which has research and clinical implications that warrant further study.

show abstract

Measurement of vascular tone and stroke volume baroreflex gain

Cited by 46 publications

References 26 publications

Racial Differences in Heart Rate Variability During Sleep in Women

Racial Differences in Heart Rate Variability During Sleep in Women

Immediate and Complex Cardiovascular Adaptation to an Acute Alcohol Dose

The effects of sighing on the cardiovascular system

Contact Info

Product

Resources

About