Measurement of Urinary S100B Protein Concentrations for the Early Identification of Brain Damage in Asphyxiated Full-term Infants

Abstract

Longitudinal S100B protein measurements in urine soon after birth are a useful tool to identify which asphyxiated infants are at risk of long-term neurologic sequelae.

S100B Maternal Blood Levels in Gestational Diabetes Mellitus Are Birthweight, Gender and Delivery Mode Dependent

“…In the present study, we also found that S100B increased in infants showing minor neurological symptoms at birth. The finding is in agreement with previous observations in high-risk fetuses and infants [14][15][16][17][18][19][20][21]29]. Further studies in a wider population aimed at investigating the correlation between a well-established factor responsible of perinatal brain impairment such as hypoxia and metabolic alterations GDM dependent are so justified.…”

Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death

“…neonatal death within 7 postnatal days. The results in healthy controls and in infants suffering hypoxic ischemic encephalopathy but not ominous outcome fit with previous observations [15], [16].…”

Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants

“…The pattern of S100s in asphyxiated and control newborns in the first 72 h after birth is in agreement with previous observations , with the finding of higher S100s concentrations in nonsurvivors than in survivors and controls providing further support . In detail, S100B in different biological fluids (amniotic fluid, urine and blood) were found to correlate with the occurrence of: (i) unexplained foetal death in the 3rd trimester of pregnancy , (ii) adverse outcome in preterm/term infants , and (iii) cerebral death in adult patients . These data suggest that A1B and BB releasing into the systemic circulation and finally in urine could be related to different events following PA insult.…”