Measurement of urinary mercury excretion by atomic absorption in health and disease

Taylor, Andrew

doi:10.1136/oem.30.3.293

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…'Normal output' has been variably reported as less than 0'5 fLmol/1 (Noe, 1960), less than 0·15 fLmol/1 (Nobel and Leifheit, 1961), and less than 0'05 fLmol/1 (Wallach, 1972). Results obtained in this laboratory using cold vapour atomic absorption spectrophotometry are in agreement with the last figure (Taylor and Marks, 1973). …”

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confidence: 80%

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Diagnostic Value of Urine Mercury Measurements

Taylor

1977

Ann Clin Biochem

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Health Authority for a wide range of trace metal and associated analyses. The total population served is approximately three million although not all laboratories with access to the Guildford centre refer specimens there for analysis, preferring to deal with them themselves.With so many referring laboratories there is inevitably considerable variation in the type and cleanliness of containers used for the collection of 24-hour urine specimens. There is little variation, however, in the type of bottles used to send aliquots from such collections to the Reference Laboratory. exposure to inorganic mercury can lead to weakness, anorexia, loss of weight, tremor, and erethisrnf. Thus, in the absence of a clear history of exposure, mercury toxicity may not immediately be suspected by a physician confronted by a patient complaining of such non-specific symptoms.Laboratory diagnosis and assessment of exposure is made by measuring mercury in urine. Urinary excretion, preferably over 24 hours, is the best index of exposure to mercury (Smith et al., 1970). 'Normal output' has been variably reported as less than 0'5 fLmol/1 (Noe, 1960), less than 0·15 fLmol/1 (Nobel and Leifheit, 1961), and less than 0'05 fLmol/1 (Wallach, 1972). Results obtained in this laboratory using cold vapour atomic absorption spectrophotometry are in agreement with the last figure (Taylor and Marks, 1973).

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confidence: 80%

“…The recovery of added mercury was 97 % and the precision of the method assessed by determination of the coefficient of variation was 5·2 % within batch and 8·1 %between batch (Taylor and Marks, 1973).…”

Section: Annals Of Clinicalmentioning

confidence: 95%

Diagnostic Value of Urine Mercury Measurements

Taylor

1977

Ann Clin Biochem

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“…Battistone et al (1973) found that the urinary mercury concentration in nonoccupationally exposed workers did not exceed 85 nmol/l (17 ,ug/l), but Taylor and Marks (1973) suggested a rather higher upper limit of around 200 nmol/l (40 ,ug/l); and Stewart et al (1977) found a range of 0-157 nmol/24 hr with a median value of 72 nmol/24 hr (14 ,g/24 hr). Taking an upper limit of normal of 150 nmol/l (30 ,ug/1), it is clear that a substantial proportion (8-2y% of dentists, 27-4y% of DSAs) of the dental personnel in this and other studies show evidence of increased mercury absorption, indeed this is only to be expected in view of their occupation.…”

Section: Discussionmentioning

confidence: 99%

Urinary mercury excretion in dental personnel.

Kelman¹

1978

Occupational and Environmental Medicine

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“…Previous investigations of mercury in urine in a reference population without any occupational exposure to mercury have shown that urinary mercury, as a rule, will be below 10 nmol/l (3,10). Geographic differences and large individual differences have been found {3).…”

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confidence: 99%